Association between the <scp>XPG</scp> gene rs2094258 polymorphism and risk of gastric cancer

Zhang, Zhe; Yin, Jiefeng; Xu, Qi; Shi, Jianfeng

doi:10.1002/jcla.22564

Cited by 7 publications

(6 citation statements)

References 36 publications

(61 reference statements)

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Section: Discussionsupporting

confidence: 92%

“…Consistent with our study, a recent meta-analysis did not observe an overall association between the XPG rs2094258 SNPs and GC risk[26]. Some studies have found associations between the rs2094258 polymorphism and GC risk[22,26-28]. For example, Yang et al[23] assessed three XPG SNPs (rs2296147T>C, rs2094258C>T, and rs873601G>A) and found that the rs2094258 C>T polymorphism was associated with an increased GC risk.…”

Section: Discussionsupporting

confidence: 90%

“…Further, the rs2296147 CC genotype was associated with a reduced risk of GC in a Chinese population (OR = 0.52, 95%CI: 0.27-0.97)[23]. These differences may be due to regional differences, small sample size, or heterogeneity of clinical feature[26].…”

Section: Discussionmentioning

confidence: 99%

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Association of XPG rs2094258 polymorphism with gastric cancer prognosis

Wang¹,

Terry²,

Yang³

et al. 2019

WJG

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BACKGROUNDThe xeroderma pigmentosum group G (XPG) gene at chromosome 13q33 consists of 15 exons, which may be related to the occurrence and development of gastric cancer (GC).AIMTo examine the association of several common single nucleotide polymorphisms (SNPs) of the XPG gene with GC risk and survival.METHODSFive SNPs of XPG (rs2094258, rs751402, rs873601, rs2296147, and rs1047768) were genotyped by PCR restriction fragment length polymorphism in 956 histologically confirmed GC cases and 1012 controls in North China. GC patients were followed for survival status and, if deceased, cause of death. Logistic regression and Cox regression were used for analysing associations of XPG SNPs with risk of GC and prognosis, respectively. For rs2094258, heterozygous model (CT vs CC), homozygous model (TT vs CC), recessive model (TT vs CT + CC), and dominant model (TT + CT vs CC) were analyzed.RESULTSNone of the examined loci were statistically associated with GC risk, although rs2296147 was marginally associated with GC risk (P = 0.050). GC patients with the rs2094258 CT + CC genotype showed worse survival than those with the TT genotype (log-rank test, P = 0.028), and patients with the CC genotype had a tendency of unfavourable prognosis compared with those with the TT + CT genotype (log-rank test, P = 0.039). The increase in C alleles of rs2094258 [hazard ratio (HR) = 1.19, 95% confidence interval (CI): 1.02-1.45, P = 0.037] were associated with the long-term survival of GC cases. Other risk factors for survival included tumor differentiation (HR = 4.51, 95%CI: 1.99-8.23, P < 0.001), lymphovascular invasion (HR = 1.97, 95%CI: 1.44-3.01, P < 0.001), and use of chemotherapy (HR = 0.81, 95%CI: 0.63-0.98, P = 0.041).CONCLUSIONThe XPG rs2094258 polymorphism may be associated with overall survival in GC patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

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Association of XPG rs2094258 polymorphism with gastric cancer prognosis

Wang¹,

Terry²,

Yang³

et al. 2019

WJG

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“…Positive Helicobacter pylori individuals with rs2094258 TT genotypes demonstrated an increased risk of gastric cancer 21 . The rs2094258 polymorphism may be associated with an increased risk of gastric cancer in Southern China 22 . The rs2094258 interacted with rs2094258 and metabolic gene GSTP1 rs1695 and formed the basis for various inter-individual susceptibilities to atrophic gastritis 23 .…”

Section: Discussionmentioning

confidence: 99%

Relationship of ERCC5 genetic polymorphisms with metastasis and recurrence of gastric cancer

Wang

Chen

Fu³

et al. 2021

Rev. Assoc. Med. Bras.

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OBJECTIVE: This study aims to explore the role of ERCC5 genetic polymorphisms in gastric cancer and their relationship with metastasis and recurrence of gastric cancer.METHODS: A total of 200 patients with gastric cancer and 133 healthy subjects were enrolled. MassARRAY iPLEX ® technology was used to genotype ERCC5 rs2016073, rs751402, rs2094258, rs2296147, and rs2296148 between the control group and the gastric cancer group. The relationship of ERCC5 genetic polymorphisms with metastasis and recurrence of gastric cancer was explored. The differences in sociodemographic characteristics between patients with gastric cancer and control subjects were compared using the chi-square test.The genetic loci between the control group and the gastric cancer group were analyzed by the chi-square test.RESULTS: There was no significant difference in the metastasis of gastric cancer between males and females (p=0.628), but there was a significant difference in the metastasis of gastric cancer (p=0.005). Patients aged ≤60 years and >60 years showed no significant difference in the metastasis of gastric cancer (p=0.420), but there was a significant difference in the recurrence of gastric cancer (p<0.001). The loci rs2016073, rs751402, and rs2094258 in the gastric cancer group showed no significant differences compared with the control group (p=0.194), and the loci rs2296147 and rs2296148 showed significant differences. CONCLUSIONS:The results suggested that ERCC5 polymorphisms (e.g., rs201607, rs751402, rs2094258, rs2296147, and rs2296148) may be associated with metastasis and recurrence of gastric cancer.

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“…GC is a multifactorial disorder, in which genetic and environmental interactions serve an important role in the development and progression [23] . Increasing age, gender, lifestyle, dietary regime, environmental factors, and Helicobacter pylori infections are among the known risk factors for stomach cancer [24] .…”

Section: Discussionmentioning

confidence: 99%

Case-control Study on p73 rs1801173 C > T Gene Polymorphism and Susceptibility to Gastric Cancer in a Chinese Han Population

Gu¹,

Wang²,

Pan³

et al. 2020

Preprint

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Objective: This study aimed to investigate the association between p73 C14T (rs1801173) polymorphism and the risk of GC in a Chinese Han population. Methods: A hospital-based case-control study was conducted. A total of 577 GC cases and 678 normal controls were recruited. Their genotypes were determined using the SnapShot method. Results: The genotype frequency distribution of the case group and the control group were consistent with the Hardy–Weinberg equilibrium. No significant difference was found in the distribution of gender, age, and drinking history between the case group and the control group. A correlation was observed between smoking and the incidence of GC (P = 0.006). Three genotypes of CC, CT, and TT were found in the rs1801173 locus of p73. The distribution of the dominant model/recessive model did not significantly differ (P = 0.688; 0.937). No statistical difference was found even after adjustment was performed via logistic regression analysis (P = 0.703; 0.990). The frequency distribution between the two groups also did not significantly differ (P = 0.763). Conclusion: Smoking is related to the occurrence and development of GC. No association was found between p73 rs1801173 C > T SNP and the risk of GC in a Chinese Han population. However, additional larger studies and tissue-specific biological characterization are required to confirm these findings.

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Association between the XPG gene rs2094258 polymorphism and risk of gastric cancer

Abstract: Xeroderma pigmentosum group G gene rs2094258 polymorphism may be associated with an increased risk of GC in Southern China. Nevertheless, the findings of this meta-analysis should be validated by well-designed large-scale case-control studies among other ethnicities.

Cited by 7 publications

References 36 publications

Association of XPG rs2094258 polymorphism with gastric cancer prognosis

Association of XPG rs2094258 polymorphism with gastric cancer prognosis

Relationship of ERCC5 genetic polymorphisms with metastasis and recurrence of gastric cancer

Case-control Study on p73 rs1801173 C > T Gene Polymorphism and Susceptibility to Gastric Cancer in a Chinese Han Population

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Association between the XPG gene rs2094258 polymorphism and risk of gastric cancer

Abstract: Xeroderma pigmentosum group G gene rs2094258 polymorphism may be associated with an increased risk of GC in Southern China. Nevertheless, the findings of this meta-analysis should be validated by well-designed large-scale case-control studies among other ethnicities.

Cited by 7 publications

References 36 publications

Association of XPG rs2094258 polymorphism with gastric cancer prognosis

Association of XPG rs2094258 polymorphism with gastric cancer prognosis

Relationship of ERCC5 genetic polymorphisms with metastasis and recurrence of gastric cancer

Case-control Study on p73 rs1801173 C &gt; T Gene Polymorphism and Susceptibility to Gastric Cancer in a Chinese Han Population

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Case-control Study on p73 rs1801173 C > T Gene Polymorphism and Susceptibility to Gastric Cancer in a Chinese Han Population