Association between the systemic immune-inflammation index and kidney stone: A cross-sectional study of NHANES 2007-2018

Abstract

BackgroundThe incidence rate of kidney stones increased over the past decades globally, which brought medical expenditure and social burden. The systemic immune-inflammatory index (SII) was initially identified as a prognosis of multiple diseases. We performed an updated analysis on the impact of SII on kidney stones.MethodsThis compensatory cross-sectional study enrolled participants from the National Health and Nutrition Examination Survey 2007-2018. Univariate and multivariate logistic regression analyses were performed to investigate the association between SII and kidney stones.ResultsOf the 22220 participants, the mean (SD) age was 49.45 ± 17.36 years old, with a 9.87% incidence rate of kidney stones. A fully adjusted model showed that SII higher than 330 x 109/L was parallel associated with kidney stones (Odds ratio [OR] = 1.282, 95% Confidence interval [CI] = 1.023 to 1.608, P = 0.034) in adults aged 20-50. However, no difference was found in the elderly subgroup. Multiple imputation analyses confirmed the robustness of our results.ConclusionsOur findings suggested SII was positively associated with a high risk of kidney stones in US adults aged less than 50. The outcome compensated for previous studies that still needed more large-scale prospective cohorts for validation.

Systemic immune-inflammation Index is associated with chronic kidney disease in the U.S. population: insights from NHANES 2007–2018

“…Di et al. reported that SII is positively connected with a high risk of kidney stones in U.S. adults under 50 years old ( 44 ). Furthermore, in patients with severe acute pancreatitis (SAP), Lu et al.…”

Association between Sitting Time and Urinary Incontinence in the US population: Data from the National Health and Nutrition Examination Survey (NHANES) 2007 to 2018

“…Multiple covariates were obtained from interviews and examinations [ 16 ], including age, race (Mexican American, non-Hispanic Black, non-Hispanic White, other Hispanic, and other races), education level (less than 12th grade, high school graduate, and college graduate), family income-to-poverty ratio (<1.3, 1.3–3.5 and >3.5), marital status, body mass index (BMI, weight/height 2 , kg/m 2 ), smoking history, alcohol consumption history (<1 drink per week, 1–3 drinks per week, and >4 or more drinks per week), moderate recreational activity, vigorous recreational activity, DM, hypertension, and coronary heart disease. Moderate recreational activity was determined by the question “In a typical week do you do any moderate-intensity sports, fitness, or recreational activities that cause a small increase in breathing or heart rate such as brisk walking, bicycling, swimming, or golf for at least 10 min continuously?“.…”

Inverse association of the systemic immune-inflammation index with serum anti-ageing protein Klotho levels in individuals with osteoarthritis: A cross-sectional study

“…The SII can be calculated through routine blood examination, which has the advantages of speed, efficiency, simplicity, and low cost. Previous studies have confirmed that the SII has good clinical value in diagnosing chronic diseases such as tumours, osteoporosis, kidney stones, and rheumatoid arthritis [ 12 – 15 ]. In addition, the SII is also considered to have good application value in predicting serum folate, albumin, vitamin B12, and vascular endothelial growth factor A (VEGF-A) concentrations [ 16 – 18 ].…”