Association Between the Presence or Severity of Coronary Artery Disease and Pericardial Fat, Paracardial Fat, Epicardial Fat, Visceral Fat, and Subcutaneous Fat as Assessed by Multi-Detector Row Computed Tomography

Ueda, Yôko; Shiga, Yuhei; Idemoto, Yoshiaki; Tashiro, Kohei; Motozato, Kota; Koyoshi, Rie; Kuwano, Takashi; Fujimi, Kanta; Ogawa, Masahiro; Saku, Keijiro; Miura, Shin‐ichiro

doi:10.1536/ihj.17-234

Cited by 31 publications

(27 citation statements)

References 32 publications

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“…In addition to its significant negative correlation with Rentrop scores, VFI (cut off value > 9) was also shown to predict the likelihood of poor CCC with a sensitivity of 95.38% and a specificity of 85.71%. Likewise, in a past study comparing the levels of pericardial fat index, paracardial fat index, and visceral fat index in patients with vs. without CAD, the levels of these fat indices were shown to be significantly higher in the CAD group and positively correlated with the number of significantly stenosed coronary vessels and the Gensini score in CAD patients (51).…”

Section: Discussionmentioning

confidence: 82%

Visceral fat index: a novel predictor for coronary collateral circulation

Şahintürk¹,

Küçükseymen²,

Avcı³

et al. 2020

Archives of Endocrinology and Metabolism

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Objective: This study was designed to investigate the role of visceral adiposity along with other clinical parameters in predicting poor coronary collateral circulation (CCC) among patients with severe obstructive coronary artery disease (CAD). Subjects and methods: A total of 135 patients with severe obstructive CAD and good (n = 70) or poor (n = 65) CCC were included. Data on angiographically detected CCC, the quality criteria for CCC (Rentrop scores) and visceral fat index (VFI) obtained via bioelectrical impedance were compared between good and poor CCC groups. Independent predictors of poor CCC, the correlation between VFI and Rentrop score and the role of VFI in the identification of CCC were analyzed. Results: A significant negative correlation was noted between VFI and Rentrop scores (r = -0.668, < 0.001). The presence of hypertension (OR 4.244, 95% CI 1.184 to 15.211, p = 0.026) and higher VFI (OR 1.955, 95% CI 1.342 to 2.848, p < 0.001) were shown to be independent predictors of an increased risk for poor CCC. ROC analysis revealed a VFI > 9 (AUC [area under the curve] (95% CI): 0.898 (0.834-0.943), p < 0.0001) to be a potential predictor of poor CCC with a sensitivity of 95.38% and specificity of 85.71%. Conclusion: In conclusion, our findings revealed comorbid hypertension and higher VFI to significantly predict the risk of poor CCC in patients with severe obstructive CAD.Arch Endocrinol Metab. 2020;64(2):150-8

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Section: Discussionmentioning

confidence: 82%

Visceral fat index: a novel predictor for coronary collateral circulation

Şahintürk¹,

Küçükseymen²,

Avcı³

et al. 2020

Archives of Endocrinology and Metabolism

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“…Our study indicates that DM patients have more EFT than non-DM patients, and this provides new ideas for the diagnosis and treatment of DM in the future and research into DM performed in the future. EFT is closely related to the occurrence of CHD [63,64]. The difference in EFT between DM patients and non-DM patients may have an important relationship with the incidence of cardiovascular diseases, but whether EFT can be used to assess the risk of cardiovascular diseases in DM patients at an early stage needs to be confirmed by further studies.…”

Section: Future Directionsmentioning

confidence: 99%

Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis

Liu

et al. 2019

Cardiovasc Diabetol

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Background: Epicardial fat tissue (EFT) is the visceral fat distributed along the coronary arteries between the pericardium and the myocardium. Increases in EFT are closely related to the occurrence of diabetes mellitus (DM) and cardiovascular disease. To further understand the link between EFT and DM, we conducted a meta-analysis of the relevant literature. Methods: We systematically searched electronic databases for studies on EFT performed in DM patients and published up to 30 September 2018. We included data on EFT in a DM patient group and a non-DM control group. We then assessed the effect of DM on EFT by meta-analysis and trial sequential analysis (TSA). All statistical analyses were performed using Stata 12.0 and TSA software. Results: A total of 13 studies (n = 1102 patients) were included in the final analysis. Compared with the control group, DM patients had significantly higher EFT (SMD: 1.23; 95% CI 0.98, 1.48; P = 0.000; TSA-adjusted 95% CI 0.91, 2.13; P < 0.0001). The TSA indicated that the available samples were sufficient and confirmed that firm evidence was reached. According to the regression analysis and subgroup analyses, DM typing, EFT ultrasound measurements, total cholesterol (TC) and triglyceride (TG) levels were confounding factors that significantly affected our results. Conclusions: Our meta-analysis suggests that the amount of EFT is significantly higher in DM patients than in non-DM patients.

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“…It has been reported that metabolic syndrome is closely associated with incident CVD. [12][13][14][15][16][17] Although both uric acid levels and metabolic syndrome are associated with CVD, only a small number of studies have evaluated the association between uric acid levels and metabolic syndrome. In the present study, the relationship between uric acid levels and incident metabolic syndrome in a Japanese general population was examined using a discrete proportional hazards regression model.…”

mentioning

confidence: 99%

Association of Uric Acid with Incident Metabolic Syndrome in a Japanese General Population

et al. 2019

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Uric acid is associated with cardiovascular disease (CVD) and its risk factors. Here, we examined the association between the serum uric acid level and incident metabolic syndrome in a Japanese general population. This retrospective, observational study was based on data obtained from an annual health checkup program in Gunma Prefecture, Japan. We evaluated 14,793 participants who did not use antihypertensive or antidiabetic medications and did not present with CVD or metabolic syndrome at the study baseline in 2009. Metabolic syndrome was defined as per the Japanese diagnostic criteria. A discrete proportional hazards regression model was used to evaluate the association between the serum uric acid level at baseline and the incident metabolic syndrome through 2012 and was adjusted for age, gender, waist circumference, systolic and diastolic blood pressure, fasting blood glucose, high-density lipoprotein cholesterol, and triglyceride. At baseline, the average age of the participants was 48.9 years, who were comprised of 40% women. The mean serum uric acid level at baseline was 5.3 ± 1.4 mg/dL. During the three-year follow-up, 7% of the cohort (n = 1,031) developed metabolic syndrome. The uric acid level was strongly associated with incident metabolic syndrome in the multivariable model (adjusted hazard ratio: 1.10; 95% confidence interval, 1.04-1.17; P < 0.01 per 1 mg/dL increase for uric acid). Higher uric acid levels were independently associated with a greater risk of incident metabolic syndrome in a Japanese general population.

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Association Between the Presence or Severity of Coronary Artery Disease and Pericardial Fat, Paracardial Fat, Epicardial Fat, Visceral Fat, and Subcutaneous Fat as Assessed by Multi-Detector Row Computed Tomography

Cited by 31 publications

References 32 publications

Visceral fat index: a novel predictor for coronary collateral circulation

Visceral fat index: a novel predictor for coronary collateral circulation

Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis

Association of Uric Acid with Incident Metabolic Syndrome in a Japanese General Population

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