Association between the interferon-induced transmembrane protein 3 gene (IFITM3) rs34481144 / rs12252 haplotypes and COVID-19

The association of ACE1, ACE2, TMPRSS2, IFITM3 and VDR polymorphisms with COVID-19 severity: a systematic review and meta-analysis

“…Basic characteristics of the remaining 29 studies (Abdollahzadeh et al, 2021[ 1 ]; Aladag et al, 2021[ 4 ]; Al-Anouti et al, 2021[ 5 ]; Alghamdi et al, 2021[ 6 ]; Akbari et al, 2022[ 2 ]; Akin et al, 2022[ 3 ]; Apaydin et al, 2022[ 7 ]; Cafiero et al, 2021[ 10 ]; Karakaş Çelik et al, 2021[ 26 ]; Cuesta-Llavona et al, 2021[ 13 ]; Gómez et al, 2020[ 20 ]; Gómez et al, 2021[ 19 ]; Gunal et al, 2021[ 21 ]; Hubacek et al, 2021[ 23 ]; Íñiguez et al, 2021[ 24 ]; Kotur et al, 2021[ 27 ]; Kouhpayeh et al, 2021[ 28 ]; Mir et al, 2021[ 33 ]; Möhlendick et al, 2021[ 34 ]; Monticelli et al, 2021[ 35 ]; Novelli et al, 2020[ 36 ]; Peralta et al, 2021[ 39 ]; Ravikanth et al, 2021[ 43 ]; Saad et al, 2021[ 45 ]; Schönfelder et al, 2021[ 49 ][ 48 ]; Verma et al, 2021[ 53 ]; Wang et al, 2022[ 55 ]; Wulandari et al, 2021[ 57 ]; Zhang et al, 2020[ 59 ]), with a total number of 8247 SARS-CoV-2-positive participants, included in qualitative data synthesis, are given in Table 1 (Tab. 1) (References in Table 1: Abdollahzadeh et al, 2021[ 1 ]; Akbari et al, 2022[ 2 ]; Akin et al, 2022[ 3 ]; Aladag et al, 2021[ 4 ]; Al-Anouti et al, 2021[ 5 ]; Alghamdi et al, 2021[ 6 ]; Apaydin et al, 2022[ 7 ]; Cafiero et al, 2021[ 10 ]; Cuesta-Llavona et al, 2021[ 13 ]; Gómez et al , 2020[ 20 ], 2021[ 19 ]; Gunal et al, 2021[ 21 ]; Hubacek et al, 2021[ 23 ]; Íñiguez et al, 2021[ 24 ]; Karakaş Çelik et al, 2021[ 26 ]; Kotur et al, 2021[ 27 ]; Kouhpayeh et al, 2021;[ 28 ] Mir et al, 2021[ 33 ]; Möhlendick et al, 2021[ 34 ]; Monticelli et al, 2021[ …”

Impact of interferon-induced transmembrane protein 3 gene rs12252 polymorphism on COVID-19 mortality

“…Cuesta-Llavona et al . indicated that the controls had a considerably greater frequency of rs12252 (AA) genotype carriers, implying a protective effect [21] . Only one study found no association between IFITM3 rs12252 polymorphisms and infection severity [13] .…”

Mucosal immune responses to infection and vaccination in the respiratory tract

“…A previous study in a mouse model concluded that Ifitm3 is important for the survival of tissue-resident CD8 + T cells upon secondary infection, and, interestingly, frequency and number of CD8 + T cells in the airways of patients with naturally acquired influenza virus infection were correlated with the genotype of rs34481144, with fewer CD8 + T cells in individuals carrying the risk allele. Interestingly, these variants have already been assessed for utility in COVID-19 risk assessment ( Cuesta-Llavona et al., 2021 ; Mohammed et al., 2021 ), and these IFITM3 variants seem likely candidate biomarkers, though again, further study across populations will be needed for validation.…”