Association Between SIRT1, Cytokines, and Metabolic Syndrome in Schizophrenia Patients With Olanzapine or Clozapine Monotherapy

Fang, Xinyu; Li, Yu; Wang, Dandan; Chen, Yan; Wang, Yewei; Wu, Zenan; Liu, Ruimei; Ren, Jun; Tang, Wei; Zhang, Chen

doi:10.3389/fpsyt.2020.602121

Cited by 15 publications

(10 citation statements)

References 58 publications

(71 reference statements)

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“…Recently, Arabska et al ( 46 ) reported that serum levels of IL-6 and TNF-α in schizophrenia patients were not significantly different with respect to healthy subjects. Significantly higher plasma levels of IL-6, IL-10, and TNF-α were, however, detected in schizophrenia patients treated with olanzapine or clozapine, as compared with normal controls ( 47 ).…”

Section: Cytokines In Schizophreniamentioning

confidence: 99%

Cytokine Imbalance in Schizophrenia. From Research to Clinic: Potential Implications for Treatment

2021

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Cytokines are one of the most important components of the immune system. They orchestrate the brain's response to infectious and other exogenous insults and are crucial mediators of the cross-talk between the nervous and immune systems. Epidemiological studies have demonstrated that severe infections and autoimmune disorders, in addition to genetic predisposition, are risk factors for schizophrenia. Furthermore, maternal infection during pregnancy appears to increase the risk of schizophrenia, and proinflammatory cytokines may be negatively involved in the neurodevelopmental process. A cytokine imbalance has been described in the blood and cerebrospinal fluid of schizophrenia patients, particularly in the T helper type 1 [Th1] and type 2 [Th2] cytokines, albeit the results of such studies appear to be contradictory. Chronic stress, likewise, appears to contribute to a lasting proinflammatory state and likely also promotes the disorder. The aim of this mini-review is to investigate the roles of different cytokines in the pathophysiology of schizophrenia and define how cytokines may represent key molecular targets to regulate for the prevention and treatment of schizophrenia. How current antipsychotic drugs impact cytokine networks is also evaluated. In this context, we propose to change the focus of schizophrenia from a traditionally defined brain disorder, to one that is substantially impacted by the periphery and immune system.

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Section: Cytokines In Schizophreniamentioning

confidence: 99%

Cytokine Imbalance in Schizophrenia. From Research to Clinic: Potential Implications for Treatment

2021

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“…Additionally, a study examining immuno-metabolic profiles identified five cytokines associated with MetS in schizophrenia, including IL-6 and TNF-α 35 . Zhang et al reported that higher plasma IL-6 levels in schizophrenia patients treated with olanzapine or clozapine and with MetS compared to patients without MetS 36 . However, our study did not yield comparable findings for IL-6, potentially attributed to our specific focus on the CR-TRS population.…”

Section: Discussionmentioning

confidence: 99%

Association of cytokines levels, psychopathology and cognition among CR-TRS patients with metabolic syndrome

Dong,

Zhu,

et al. 2024

Schizophr

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Clozapine-resistant treatment-refractory schizophrenia (CR-TRS) patients face significant clinical challenges. While links between metabolic syndrome (MetS) and inflammatory cytokines in schizophrenia have been established, the relationship between MetS and cytokine levels in CR-TRS patients remains unexplored. This study aimed to investigate the relationship between cytokines levels, clinical symptoms and cognitive impairments in CR-TRS patients, both with and without MetS. The study included 69 CR-TRS patients (31with MetS and 38 without MetS) and 84 healthy controls. The levels of IL-2, IL-6, TNF-α and routine biochemical parameters were measured. Psychopathological symptoms and cognitive function were assessed using the Positive and Negative Syndrome Scale (PANSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), respectively. We found that CR-TRS patients with MetS displayed lower cognitive function scores compared to those without MetS, even when accounting for potential confounders. TNF-α levels were significantly higher in CRTRS patients with MetS compared to those without MetS, demonstrating substantial pathophysiological potential for CR-TRS patients with MetS via receiver operating characteristic curve (ROC). In CR-TRS patients without MetS, IL-2 independently contributed to the total score and general psychopathology subscore of PANSS. Additionally, IL-6 exhibited an independent contribution to the positive subscore of PANSS. In terms of cognition function, IL-6 independently contributed to the delayed memory of RBANS in CR-TRS patients without MetS. TNF-α could potentially serve as a predictive marker for distinguishing between CR-TRS patients with/without MetS, while IL-2 and IL-6 could independently contribute to psychopathological symptoms or cognitive function in CRTRS patients without MetS. Our study provided insights into the potential interplay between cytokines, clinical symptoms and cognitive impairments in CR-TRS patients with/without MetS.

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“…These inflammatory cytokines play vital roles in the pathogenesis of IR and MS. Patients with MS have higher blood levels of IL-6, 33 TNF-α, 34 and IL-1β. 35 Chronic IL-6 exposure led to IR and related metabolic disorders in a murine model.…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation of l-carnitine ameliorates metabolic syndrome independent of trimethylamine N-oxide produced by gut microbes in high-fat diet-induced obese mice

et al. 2022

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Association Between SIRT1, Cytokines, and Metabolic Syndrome in Schizophrenia Patients With Olanzapine or Clozapine Monotherapy

Cited by 15 publications

References 58 publications

Cytokine Imbalance in Schizophrenia. From Research to Clinic: Potential Implications for Treatment

Cytokine Imbalance in Schizophrenia. From Research to Clinic: Potential Implications for Treatment

Association of cytokines levels, psychopathology and cognition among CR-TRS patients with metabolic syndrome

Dietary supplementation of l-carnitine ameliorates metabolic syndrome independent of trimethylamine N-oxide produced by gut microbes in high-fat diet-induced obese mice

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