Association between shorter telomeres’ length and Eotaxin-1 in children with severe asthma, an indicative of accelerated aging

Barbé-Tuana, Florencia Marı́a; Grün, Lucas Kich; Pitrez, Paulo Márcio; Parisi, Mariana Migliorini; Pierdoná, Vinícius; Guma, Fátima Theresinha Costa Rodrigues; Pinto, Leonardo Araújo; Stein, Renato T.; Jones, Marcus Herbert

doi:10.1183/13993003.congress-2019.oa3594

Cited by 2 publications

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“…Interestingly, in silico analysis (Netlogo version 6.1.1) demonstrated a correlation between eotaxin-1 (CCL11) levels and asthma severity. This study identified shorter telomeres in subjects, including children, with severe asthma compared to mild asthma and controls, which could be due to CCL11 promoting superoxide secretion and double-strand breaks, then inducing reduction of telomere length and contributing to an accelerated ageing phenotype [12].…”

Section: Mechanisms and Physiologymentioning

confidence: 83%

ERS International Congress, Madrid, 2019: highlights from the Airway Diseases, Asthma and COPD Assembly

et al. 2020

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The European Respiratory Society (ERS) International Congress 2019 in Madrid, Spain, was a platform for scientific discussion of the highest quality scientific research, cutting-edge techniques and innovative new therapies within the respiratory field. This article discusses some of the high-quality research studies presented at that Congress, with a focus on airway diseases, including asthma, COPD, small airways, bronchiectasis and cough, presented through the Airway Diseases, Asthma and COPD Assembly (Assembly 5) of the ERS. The authors establish the key take-home messages of these studies, compare their findings and place them into context of current understanding.

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Section: Mechanisms and Physiologymentioning

confidence: 83%

ERS International Congress, Madrid, 2019: highlights from the Airway Diseases, Asthma and COPD Assembly

et al. 2020

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“…38 For example, the majority of those with chronic bronchitis/emphysema report significant nasal symptoms. 39 Alternatively, lungs of patients with asthma 40 and COPD 41 exhibit remarkable characteristics of accelerated aging due to chronic inflammation, from increase in cellular senescence to stem cell exhaustion to increased oxidative stress. Accelerated aging in chronic lung disease may affect the olfactory epithelium in a similar fashion.…”

Section: Discussionmentioning

confidence: 99%

Olfactory decline develops in parallel with frailty in older US adults with obstructive lung diseases

Wang,

Wroblewski,

McClintock

et al. 2023

Int Forum Allergy Rhinol

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BackgroundFrailty is prevalent among older adults with asthma or chronic obstructive pulmonary disease (obstructive lung diseases [OLDs]). Frailty and OLD's co‐occurrence is associated with increased hospitalization/mortality. Chemosensory dysfunction is closely connected to both OLD and frailty. We evaluated the utility of olfactory decline as a biomarker of frailty in the setting of OLD.MethodsWe performed a prospective, longitudinal, nationally representative study of community‐dwelling older US adults in the National Social Life, Health and Aging Project, an omnibus in‐home survey. Respondents reported a physician's diagnosis of OLD. Decline in odor identification and sensitivity over 5 years and frailty (adapted fried frailty phenotype criteria) were measured using standard tools. Multivariate logistic regressions evaluated the association between OLD status, olfactory decline, and frailty.ResultsWe compared individuals with OLD (n = 98; mean age 71.2 years, 59.2% women) and those without OLD (n = 1036; mean age 69.5 years, 58.9% women). Olfactory identification decline was associated with developing frailty over the 5‐year follow‐up period in individuals with OLD (odds ratio [OR] = 9.1, 95% confidence interval [CI] = 2.1–38.6, p = 0.003). Olfactory decline predicted incidence of frailty in individuals with OLD (identification: OR = 4.8, 95% CI = 1.3–17.5, P = 0.018; sensitivity: OR = 6.1, 95%CI = 1.2–31.0, p = 0.030) but not in those without OLD adjusting for demographics, heavy alcohol use, current smoking, and comorbidity. Results were robust to different thresholds for olfactory decline and frailty development.ConclusionsOlder adults with OLD who experience olfactory decline face higher odds of developing frailty. Use of olfactory decline as a biomarker to identify frailty could allow earlier intervention and decrease adverse outcomes for high‐risk older adults with OLD.

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Association between shorter telomeres’ length and Eotaxin-1 in children with severe asthma, an indicative of accelerated aging

Cited by 2 publications

References 0 publications

ERS International Congress, Madrid, 2019: highlights from the Airway Diseases, Asthma and COPD Assembly

ERS International Congress, Madrid, 2019: highlights from the Airway Diseases, Asthma and COPD Assembly

Olfactory decline develops in parallel with frailty in older US adults with obstructive lung diseases

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