Association Between Serum Vitamin D Levels and Colonic Carcinomatous Polyps

Sy, Alexander; Bautista, Josef

doi:10.1007/s12029-013-9533-3

Cited by 10 publications

(7 citation statements)

References 13 publications

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“…Vitamin D exerts several biological effects other than the wellknown regulation of calcium and phosphorus metabolism: it has a role in activating innate and adaptive immunity (15,16) thus having a potential role in preventing infection, and it is also able to influence neo-angiogenesis (17,18) and pathways of apoptosis (19,20). Accumulating evidence has shown that vitamin D deficiency is associated with a higher risk of developing different types of cancer (21)(22)(23) and it may, thus, have a role in the diagnosis of HCC, together with other markers already known to be useful in the diagnosis of such neoplasia [e.g. alphafetoprotein (AFP), protein induced by vitamin K absence-II and their combination] (24).…”

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confidence: 99%

Severe Vitamin D Deficiency Increases Mortality Among Patients With Liver Cirrhosis Regardless of the Presence of HCC

Buonomo

Scotto

Zappulo

et al. 2018

In Vivo

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Background: The aim of this study was to investigate the association between vitamin D deficiency (<10 mg/ml) and mortality in patients with and without hepatocellular carcinoma (HCC) in a cohort of patients with liver cirrhosis. Materials and Methods: A prospective study was conducted among 345 patients with liver cirrhosis. Results: At enrolment, 46 (13.3%) patients had HCC. Severe vitamin D deficiency was associated with mortality (p<0.01). At the survival analysis, alpha-fetoprotein >10 ng/ml (p=0.003), vitamin D deficiency (p<0.001), a Model for End-Stage Liver Disease score ≥15 (p<0.001), Child-Pugh class B and C (versus A) (p<0.001) and the presence of active HCC (p<0.001) were strongly associated with death. At the multivariate Cox regression analysis, only Child-Pugh class B and C (versus A) and vitamin D deficiency were found to be significantly associated with death during the follow-up period (p<0.001 and p=0.006, respectively). Conclusion: Vitamin D deficiency is common in patients with HCC, it is associated with active HCC and it negatively affects the overall survival of patients with cirrhosis.

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confidence: 99%

Severe Vitamin D Deficiency Increases Mortality Among Patients With Liver Cirrhosis Regardless of the Presence of HCC

Buonomo

Scotto

Zappulo

et al. 2018

In Vivo

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“…Adams et al [27] suggested that the established inverse association between circulating VD and colonic adenoma may not apply to hyperplastic polyps. However, Sy and Bautista [28] pointed out a possible threshold effect of 25(OH)VitD 3 at < 30 ng/ml associated with increasing odds of being colonic polyps.…”

Section: Discussionmentioning

confidence: 99%

Is there an association between serum vitamin D levels and endometrial polyps?

Özakşit¹,

Tokmak²,

Kalkan³

et al. 2016

Clin. Exp. Obstet. Gynecol.

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Background/Aim: Anti-proliferative effects of vitamin D (VD) had been proposed previously. Herein, the authors aimed to evaluate serum 25(OH)VitD3 levels in women with endometrial polyps (EPs) and to determine whether VD deficiency is a risk factor for EP formation. Materials and Methods: This study was designed as a controlled cross-sectional study. Forty three women with polyps constituted the study group whereas 47 of them constituted the control group. The selection criteria for the study group were hysteroscopic detection and histological confirmation of EPs. The main parameters recorded for each woman were; age, body mass index (BMI), parity, smoking status, co-morbidities, dressing style, dairy intake of VD-rich foods, duration of sunlight exposure, skin photo-type, serum levels of 25(OH)VitD3, calcium, phosphor, and albumin. Results: The mean serum 25(OH)VitD3 level was 8.3±7.7 ng/ml in the study group and 9.3 ± 10.2 ng/ml in the control group (p = 0.583). Mean BMI was statistically significantly higher in the study group (p = 0.003). Logistic regression model showed that only significant risk factor for EPs was increased BMI (OR=1.241; 95% CI = 1.070-2.440; p = 0.004). Conclusion: VD deficiency is common among the reproductive age women and obesity is the most important risk factor for polyp formation. The authors believe that there is no relation between VD and EPs.

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“…Studies conducted in western countries have demonstrated the protective role of vitamin D for CRPs and CRC [ 13 ]. However, other studies have also proposed that vitamin D is not related to CRC [ 14 , 15 ]. One study even reported that Ca and vitamin D supplementation may increase the risk of sessile serrated adenomas or polyps [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Association of 25(OH)-Vitamin D and metabolic factors with colorectal polyps

Chiang¹,

Chang²,

He³

et al. 2023

PLoS ONE

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Background Studies have revealed the association of vitamin D with specific types of cancer development, however, its correlation with colorectal polyps (CRPs) remains unverified. Our study aimed to investigate the relationship between vitamin D levels, metabolic factors, and CRPs. Methods A cross-sectional study from 2017 to 2019 involving 1306 participants was conducted to investigate the association among vitamin D levels, metabolic factors, uric acid and CRPs in Taiwan. CRPs diagnoses were determined via colonoscopies conducted by experienced gastrointestinal physicians, and biopsied polyps were inspected under a microscope by experienced pathologists. We employed both simple and multiple logistic regression analyses to identify significant factors associated with CRPs and adenomatous polyps, respectively. Results Our result showed that the prevalence of 25(OH)-vitamin D deficiency (≦ 20 ng/mL) and CRPs was 21.21% and 40.89%, respectively. Multiple logistic regression revealed that the risk of CRPs increased with old age, male sex, hyperglycemia, high triglyceride levels, and low 25(OH)D levels after adjustment for other factors. Besides, low 25(OH)D levels were significantly associated with CRPs risk in women, whereas elevated blood pressure was associated with CRPs risk in men. 25(OH)D Deficiency was revealed to be significantly associated with risk of CRPs in adults over 50 years old. Compared to nonadenomatous polyps, older age, higher 25(OH) vitamin D and higher uric acid levels were at increased risk for adenomatous polyps. Conclusions Our study revealed that vitamin D deficiency was significantly associated with the risk of CRPs, especially in adults over 50 years old and women. We should therefore be concerned about the CRP risk of vitamin D deficiency and metabolic syndrome (especially hyperglycemia, elevated blood pressure in men, and high triglyceride levels) in this population.

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Association Between Serum Vitamin D Levels and Colonic Carcinomatous Polyps

Abstract: Vitamin D levels, using two established cutoffs, are not significantly associated with increased odds of membership in the CP+ group. However, our data suggest a possible threshold effect of vitamin D at <30 ng/ml associated with increasing odds of being CP+.

Cited by 10 publications

References 13 publications

Severe Vitamin D Deficiency Increases Mortality Among Patients With Liver Cirrhosis Regardless of the Presence of HCC

Severe Vitamin D Deficiency Increases Mortality Among Patients With Liver Cirrhosis Regardless of the Presence of HCC

Is there an association between serum vitamin D levels and endometrial polyps?

Association of 25(OH)-Vitamin D and metabolic factors with colorectal polyps

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