Association between serum prolactin levels and insulin resistance in non-diabetic men

Daimon, Makoto; Kamba, Aya; Murakami, Hiroshi; Mizushiri, Satoru; Osonoi, Sho; Yamaichi, Masato; Matsuki, Kota; Sato, Eri; Tanabe, Jutaro; Takayasu, Shinobu; Matsuhashi, Yuki; Yanagimachi, Miyuki; Terui, Ken; Kageyama, Kazunori; Tokuda, Itoyo; Takahashi, Ippei; Nakaji, Shigeyuki

doi:10.1371/journal.pone.0175204

Cited by 52 publications

(50 citation statements)

References 39 publications

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“…In fact, several recent prospective studies suggested that the associations between prolactin and risk of type 2 diabetes and the metabolic syndrome were more likely to be beneficial in women but tended to be null or even detrimental in men [17–21]. The reason underlying this sex difference is unclear, as both beneficial and detrimental effects of prolactin on IR have been reported in men [12, 44]. Nevertheless, our data, coupled with prior evidence, suggest that prolactin may be related to pathogenic pathways leading to the development of type 2 diabetes in women.…”

Section: Discussionmentioning

confidence: 99%

Circulating prolactin concentrations and risk of type 2 diabetes in US women

Rice

Huang

et al. 2018

Diabetologia

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Aims/hypothesis Prolactin, a multifunctional hormone, is involved in regulating insulin sensitivity and glucose homeostasis in experimental studies. However, whether circulating concentrations of prolactin are associated with risk of type 2 diabetes remains uncertain. Methods We analysed the prospective relationship between circulating prolactin concentrations and type 2 diabetes risk in the Nurses’ Health Study (NHS) and NHSII with up to 22 years of follow-up. Total plasma prolactin was measured using immunoassay in 8615 women free of type 2 diabetes and cardiovascular disease at baseline blood collection (NHS 1989–1990; NHSII 1996–1999) and a subset of 998 NHS women providing a second blood sample during 2000–2002. Baseline bioactive prolactin was measured in a subset of 2478 women using the Nb2 bioassay. HRs were estimated using Cox regression. Results A total of 699 incident type 2 diabetes cases were documented during 156,140 person- years of follow-up. Total plasma prolactin levels were inversely associated with type 2 diabetes risk; the multivariable HR comparing the highest with the lowest quartile was 0.73 (95% CI 0.55, 0.95; ptrend=0.02). The associations were similar by menopausal status and other risk factors (pinteraction>0.70). Additional adjustment for sex and growth hormones, adiponectin, and inflammatory and insulin markers did not significantly alter the results. The association of plasma bioactive prolactin with type 2 diabetes risk was non-significantly stronger than that of total prolactin (HR comparing extreme quartiles, 0.53 vs 0.81 among the subset of 2478 women, pdifference=0.11). The inverse association of total prolactin with type 2 diabetes was significant during the first 9 years after blood draw but waned linearly with time, whereas for bioactive prolactin, the inverse relationship persisted for a longer follow-up time after blood draw. Conclusions/interpretation A normally high circulating total prolactin concentration was associated with a lower type 2 diabetes risk within 9–10 years of follow-up since blood draw in US women. Our findings are consistent with experimental evidence, suggesting that among healthy women, prolactin within the biologically normal range may play a protective role in the pathogenesis of type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Circulating prolactin concentrations and risk of type 2 diabetes in US women

Rice

Huang

et al. 2018

Diabetologia

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“…This study was part of the Iwaki Health Promotion Project, an ongoing community-based health promotion study of Japanese people over 20 years of age with the aim of preventing lifestyle-related diseases and prolonging lifespans. [18][19][20][21] The study has been conducted annually since 2005 in the Iwaki area of the city of Hirosaki in Aomori Prefecture, northern Japan. All subjects volunteered to participate in response to a public announcement, and approximately 600 items of data from each participant, including body mass index, medical histories (hypertension, diabetes mellitus, and dyslipidemia), and blood pressure, were recorded.…”

Section: Methodsmentioning

confidence: 99%

Novel Electrocardiographic Criteria for the Diagnosis of Left Ventricular Hypertrophy in the Japanese General Population

et al. 2019

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Although there are several diagnostic criteria for left ventricular hypertrophy (LVH), their sensitivity remains low. A recent study reported that the sum of the amplitude of the deepest S wave in any lead (SD) and the S wave in lead V4 (SV4) (SD + SV4) improved sensitivity compared with commonly used criteria. To test whether this new formula improves sensitivity in the Japanese general population, we analyzed 12-lead electrocardiograms for Japanese residents participating in the Iwaki Health Promotion Project (n = 866). Left ventricular mass was calculated by echocardiography, indicating that 156 (18%) of the study population had LVH. In receiver operating characteristic analyses, the sum of the R wave in limb lead Ι (RLΙ) and the S wave in V4 (SV4) (RLΙ + SV4) showed a higher area under the curve (AUC = 0.76) than the Sokolow-Lyon voltage criteria (0.61) and the SD + SV4 criteria (0.63), and almost the same AUC as the Cornell voltage criteria (0.74) and the Cornell product criteria (0.76). The validation study also showed similar results. The cutoff values of RLΙ + SV4 criteria were ! 1.6 mV in men and ! 1.4 mV in women with a sensitivity of 39% and a specificity of 89%, whereas the sensitivity and specificity calculated based on SD + SV4 criteria were 21% and 94%, respectively. Thus, the diagnostic criterion of RLΙ + SV4 seems to be more useful than the previous criteria for diagnosing LVH in the Japanese general population.

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“…This study was part of the Iwaki Health Promotion Project, which is an ongoing community-based health promotion study of Japanese people over 20 years of age that aims to prevent lifestylerelated diseases and prolong lifespans. [15][16][17] The study has been conducted annually since 2005 in the Iwaki area of the city of Hirosaki in Aomori Prefecture, which is located in northern Japan. All study subjects participated voluntarily in response to a public announcement and approximately 600 items were collected from each participant, including a standard 12-lead ECG, body weight, medical history, cardiovascular risk factors, and blood chemical analysis results.…”

Section: Study Populationmentioning

confidence: 99%

Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan

et al. 2018

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We previously showed that J-waves were found more frequently in patients with low levels of serum eicosapentaenoic acid (EPA) in the acute phase of myocardial infarction, and were associated with the incidence of ischemia-related ventricular arrhythmias. However, the relationship between J-waves and serum EPA levels in a general population remains to be elucidated.The Iwaki Health Promotion Project is an ongoing community-based health promotion study in Iwaki, Hirosaki, which is in northern Japan. A total of 1,052 residents (mean age, 53.9 ± 15.4 years; 390 men) who participated in this project in 2014 were studied. A standard 12-lead electrocardiogram (ECG) was recorded and serum EPA levels were measured to evaluate the relationship between J-waves and serum EPA levels. J-waves were found in 52 (5%) subjects and were observed more frequently in male than female subjects (44 [11%] versus 8 [1%], P < 0.0001). More than half of the J-waves were the notched type (60%), and J-waves were detected most frequently in inferior leads on ECG (52%). The RR interval was longer and QTc duration shorter in subjects with J-waves than those without. No significant difference was found in serum EPA levels between subjects with and without J-waves (70 [49-116] versus 65 [41-106] μg/mL, P = 0.40). In multivariate analysis, male gender and RR interval were independent factors associated with the presence of J-waves.There was no significant relationship between J-waves and serum EPA levels in this general population in Japan. Various mechanisms for manifestation of the J-waves are suggested.

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Association between serum prolactin levels and insulin resistance in non-diabetic men

Cited by 52 publications

References 39 publications

Circulating prolactin concentrations and risk of type 2 diabetes in US women

Circulating prolactin concentrations and risk of type 2 diabetes in US women

Novel Electrocardiographic Criteria for the Diagnosis of Left Ventricular Hypertrophy in the Japanese General Population

Relationship Between Serum Eicosapentaenoic Acid Levels and J-Waves in a General Population in Japan

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