JAMA
 2012
DOI: 10.1001/2012.jama.11030
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Association Between Sentinel Lymph Node Excision With or Without Preoperative SPECT/CT and Metastatic Node Detection and Disease-Free Survival in Melanoma

Ingo Stoffels
1
,
Christian Boy2,
Thorsten Pöppel3
et al.
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Cited by 137 publications

(83 citation statements)
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“…The authors showed SPECT/CT identified more SLNs compared to PLS, 2.40 versus 1.87, respectively ( p < 0.001). 1 This finding was consistent with previous, smaller studies. 11, 12 The authors concluded the potential advantages of SPECT/CT encompassed additional three-dimensional anatomic detail, which could assist in more accurate placement of the surgical incision allowing the surgeon to identify the SLN with less dissection and overall less morbidity.…”
supporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The authors showed SPECT/CT identified more SLNs compared to PLS, 2.40 versus 1.87, respectively ( p < 0.001). 1 This finding was consistent with previous, smaller studies. 11, 12 The authors concluded the potential advantages of SPECT/CT encompassed additional three-dimensional anatomic detail, which could assist in more accurate placement of the surgical incision allowing the surgeon to identify the SLN with less dissection and overall less morbidity.…”
supporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…They detected with SPECT/CT significantly more SLNs per patient than with planar imaging alone leading to a significantly higher rate of identified metastatic SLNs per patient with SPECT/CT (17). With SPECT/CT significantly fewer patients had a local relapse than with planar imaging alone, which prolonged 4-year disease-free survival (17). In the present study, we could confirm these findings.…”
Section: Discussionsupporting
confidence: 77%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The number of positive SLN per patient was significantly higher in the SPECT/CT cohort (0.34 vs 0.21; p = 0.038). The local relapse rate in the SPECT/CT cohort was lower than in the standard cohort (6.8% vs 23.8%, p = 0.021), which prolonged disease-free survival ( p = 0.019) [14]. This study confirms the improved identification of SLN in overweight and obese melanoma patients [17] as well as those with tumors in the head and neck area [18, 19].…”
Section: Introductionsupporting
confidence: 62%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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