Association between psoriasis and migraine: what should we expect from a meta-analysis?

Abstract

Background Although many studies have demonstrated the commodity of psoriasis with migraine and indicated that they may have similar susceptibility genes and pathophysiologic mechanism, the clinic association between the migraine and psoriasis remains unclear. Methods We have already searched Pubmed, Embase, and Web of Science for case–control, cross-sectional, or cohort studies, and extract rate, odds or risk of migraine in subjects with psoriasis or without psoriasis. Using defined inclusion and exclusion criteria, finally include nine studies. Pooling of the suitable data was applied when necessary. Results Five cross-sectional studies included 6355 psoriasis patients and 934413 controls, migraine highly occurred in psoriasis patient (pooled OR 1.64; 95% confidence interval [1.28; 2.11]). In addition, with 4375 psoriasis patients provided, the rate of migraine occurred in psoriasis patient (pooled rate 0.21; 95% confidence interval [0.13; 0.35]). Conclusion Migraine and psoriasis present a clear co-occurrence and similar pathophysiologic mechanism, which lead to the assumption that the two diseases might be linked. Screening and selection of proper assessment of migraine among psoriasis patients are warranted and needed.

Immunologic aspects of migraine: A review of literature

“…This study indicated a significant association between migraine and psoriasis OR 1.64 (95% CI 1.28; 2.11). Although the underlying causes for this association have not been observed, pathophysiological, molecular, and therapeutic aspects should be considered explanatory factors ( 306 ). Migraine with aura (MA) is an independent risk factor for the cardiovascular system (CV) in people under 45 years of age ( 307 , 308 ), and the number of MA crises is a sign of the severity of CV ( 309 , 310 ).…”

Evaluation of the relationship between migraine and psoriasis: a case-control study

“…Additionally, the results of a recent meta-analysis also indicated the increased risk of migraine in psoriatic patients compared to the non-psoriatic control group (OR = 1.64, 95% CI 1.28‒2.11). 31 …”