2016
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Abstract: Introduction: This study was aimed to determine the association between PSA levels and biomarkers of subclinical systemic inflammation based on data from 119 middle-aged healthy men from the general population. Materials and Methods: Serum levels of PSA and biomarkers of systemic inflammation (CRP and fibrinogen) were measured. Demographic data were also collected. Subjects were divided into two groups according to PSA levels; < 2 ng/ml and ≥ 2 ng/ml. Results: The mean (SD) age of men was 55 ± 4.0 years. We fo… Show more

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“…In addition to the above proposed biological mechanisms, it has also been hypothesized that detection bias due to lower serum PSA levels, often seen in diabetic men, 45 may mask the presence of PCa or delay its detection, leading to an apparent reduced risk, 46 in men with IGR (including diabetes). Additionally, several studies have shown that serum testosterone levels are positively associated with PSA levels 47,48 . Thus our findings could also reflect a reduced detection of PCa in men with higher HbA1c levels, rather than any actual reduced risk of PCa development.…”
Section: Discussionmentioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…In addition to the above proposed biological mechanisms, it has also been hypothesized that detection bias due to lower serum PSA levels, often seen in diabetic men, 45 may mask the presence of PCa or delay its detection, leading to an apparent reduced risk, 46 in men with IGR (including diabetes). Additionally, several studies have shown that serum testosterone levels are positively associated with PSA levels 47,48 . Thus our findings could also reflect a reduced detection of PCa in men with higher HbA1c levels, rather than any actual reduced risk of PCa development.…”
Section: Discussionmentioning
“…Acknowledging the large differences in PSA recommendations, development of personalized screening is inevitable. Previous results suggest a link between inflammation and tPSA elevation among healthy men without urologic disorders (18). While many inflammatory diseases are often well recognized by patients and physicians, CP is often underestimated even in dental examination.…”
Section: Discussionmentioning
“…The main cause of PCa is unknown but age, genetic factors, diet and environmental factors are focused on the etiology 8 . Serum PSA testing is the most widely accepted and used biomarker for prostatic diseases especially PCa 9 . But PSA is not cancer‐specific marker, increases in benign prostate diseases and there is no threshold value of PSA for cancer diagnosis 1 .…”
Section: Discussionmentioning
“…8 Serum PSA testing is the most widely accepted and used biomarker for prostatic diseases especially PCa. 9 But PSA is not cancer-specific marker, increases in benign prostate diseases and there is no threshold value of PSA for cancer diagnosis. 1 In general, PSA over 4 ng/mL is recommended for biopsy, the cancer detection rate is between 20% and 25% in patients with a PSA value of 4-10 ng/mL.…”
Section: Discussionmentioning