Association between prenatal exposure to polybrominated diphenyl ethers and young children's neurodevelopment in China

Ding, Guodong; Yu, Jiang; Cui, Chong; Chen, Limei; Gao, Yu; Wang, Cai‐Feng; Zhou, Yijun; Tian, Ying

doi:10.1016/j.envres.2015.06.008

Cited by 74 publications

(50 citation statements)

References 63 publications

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“…Eskenazi et al found that maternal ΣPBDEs were significantly associated with poor fine motor dexterity at five and seven years of age and with finger taps at age five [29]. Gascon et al, Shy et al, Chen et al, Ding et al, and Sagiv et al detected no significant associations with motor function at ages four, five, one and two, or nine and twelve years, respectively [24,26,27,30,31]. …”

Section: Resultsmentioning

confidence: 99%

“…All analyses were derived from longitudinal birth cohorts—three from Europe (France, Spain, and the Netherlands [23,24,25]); three from Asia (China, Taiwan, and Korea [26,27,28]); and three from North America. The North American birth cohorts were: CHAMACOS in Salinas Valley, California [29,30], HOME in Cincinnati, Ohio [31,32,33,34,35,36], and World Trade Center in New York, New York [37,38].…”

Section: Summary Of Studiesmentioning

confidence: 99%

“…The studies tested for a range of exposures to different congeners, but the present review focuses on BDE-47, -99, -100, -153, and the sum of the concentrations of these congeners as they are most consistently found in the environment and in human blood samples [11] (Figure 2). The year of exposure measurement varied from 1997 in INMA [24] to 2012 in Laizhou Wan [26]. Six of the studies (in the WTC, CHAMACOS, INMA, and COMPARE cohorts) measured exposure prior to 2004 [23,24,29,30,37,38], the year when penta- and octa-BDEs were phased out or banned in their respective locations, and seven studies (in the HOME and PELAGIE cohorts) measured exposure between 2002 and 2006 and included the year of congener removal in the enrollment window [31,32,33,34,35,36].…”

Section: Summary Of Studiesmentioning

confidence: 99%

“…Six of the studies (in the WTC, CHAMACOS, INMA, and COMPARE cohorts) measured exposure prior to 2004 [23,24,29,30,37,38], the year when penta- and octa-BDEs were phased out or banned in their respective locations, and seven studies (in the HOME and PELAGIE cohorts) measured exposure between 2002 and 2006 and included the year of congener removal in the enrollment window [31,32,33,34,35,36]. The studies in Asia were conducted in 2009 [27], 2011–2012 [28], and 2012 [26], but no regulation currently exists for PBDE exposure in either China or Korea [39], and Taiwanese regulation did not take effect until 2016. Depending on the study, prenatal PBDE exposure was measured in either maternal and/or cord blood.…”

Section: Summary Of Studiesmentioning

confidence: 99%

“…Dyads were followed from birth through between one and twelve years of age. Results were reported in terms of a shift in the population distribution of outcome scores, using estimated betas from linear regression based on one or multiple measures of exposure and outcome in HOME, PELAGIE, CHAMACOS, WTC, CHECK, and the Laizhou Wan cohorts [25,26,28,29,30,31,32,33,34,35,36,38], and in terms of group odds or risk of outcomes, using odds ratios in HOME, CHAMACOS, and the Taiwanese cohort [27,29,31], risk ratios in INMA [24], and incidence rate ratios in WTC [37]. One study reported correlations between exposure and outcomes [23].…”

Section: Summary Of Studiesmentioning

confidence: 99%

See 4 more Smart Citations

Effects of Polybrominated Diphenyl Ethers on Child Cognitive, Behavioral, and Motor Development

Gibson

Siegel

Eniola

et al. 2018

IJERPH

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Polybrominated Diphenyl Ether (PBDE) flame retardants are environmental chemicals that cross the placenta during pregnancy and have shown evidence of neurotoxicity. As the in utero period is a sensitive developmental window, such exposure may result in adverse childhood outcomes. Associations between in utero PBDE exposure and neurodevelopment are found in animal models and increasingly in human population studies. Here, we review the epidemiological evidence of the association between prenatal exposure to PBDEs and motor, cognitive, and behavioral development in infants and children. Published work suggests a negative association between PBDE concentrations and neurodevelopment despite varying PBDE congeners measured, bio-specimen matrix used, timing of the biological sampling, geographic location of study population, specific developmental tests used, age of children at time of testing, and statistical methodologies. This review includes 16 published studies that measured PBDE exposure in maternal blood during pregnancy or in cord blood at delivery and performed validated motor, cognitive, and/or behavioral testing at one or more time during childhood. We evaluate possible mediation through PBDE-induced perturbations in thyroid function and effect measure modification by child sex. While the majority of studies support an adverse association between PBDEs and neurodevelopment, additional research is required to understand the mechanism of action, possibly through the perturbations in thyroid function either in the pregnant woman or in the child, and the role of biologically relevant effect modifiers such as sex.

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Section: Resultsmentioning

confidence: 99%

Section: Summary Of Studiesmentioning

confidence: 99%

Section: Summary Of Studiesmentioning

confidence: 99%

Section: Summary Of Studiesmentioning

confidence: 99%

Section: Summary Of Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Polybrominated Diphenyl Ethers on Child Cognitive, Behavioral, and Motor Development

Gibson

Siegel

Eniola

et al. 2018

IJERPH

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Assessing Children's Exposure to Contaminants in House Dust

DeLuca,

Cohen Hubal

2024

Human and Ecological Risk Assessment

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Multi‐spectroscopic and molecular dynamics simulations investigation of the binding mechanism of polybrominated diphenyl ethers to hen egg white lysozyme

Zuo

Rui

et al. 2019

Luminescence

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Three PBDEs (BDE25, BDE47, and BDE154) were selected to investigate the interactions between PBDEs and hen egg white lysozyme (HEWL) by molecular modeling, fluorescence spectroscopy, and FT-IR spectra. The docking results showed that hydrogen bonds were formed between BDE25 and residue TRP63 and between BDE47 and TRP63 with bond lengths of 2.178 Å and 2.146 Å, respectively. The molecular dynamics simulations indicated that van der Waals forces played a predominant role in the binding of three PBDEs to HEWL. The observed fluorescence quenching can be attributed to the formation of complexes between HEWL and PBDEs, and the quenching mechanism is a static quenching. According to Förster's non-radiative energy transfer theory, the binding distances r were < 7 nm, indicating a high probability of energy transfer from HEWL to the three PBDEs. The synchronous fluorescence showed that the emission maximum wavelength of tryptophan (TRP) residues emerged a red-shift. FT-IR spectra indicated that BDE25, BDE47 and BDE154 induced the α-helix percentage of HEWL decreased from 32.70% ± 1.64% to 28.27% ± 1.41%, 27.50% ± 1.38% and 29.78% ± 1.49%, respectively, whereas the percentage of random coil increased from 26.67% ± 1.33% to 27.60% ± 1.38%, 29.18% ± 1.46% and 30.59% ± 1.53%, respectively. KEYWORDSbinding free energy, fluorescence spectroscopy, hen egg white lysozyme, molecular modeling, polybrominated diphenyl ethers

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Association between prenatal exposure to polybrominated diphenyl ethers and young children's neurodevelopment in China

Cited by 74 publications

References 63 publications

Effects of Polybrominated Diphenyl Ethers on Child Cognitive, Behavioral, and Motor Development

Effects of Polybrominated Diphenyl Ethers on Child Cognitive, Behavioral, and Motor Development

Assessing Children's Exposure to Contaminants in House Dust

Multi‐spectroscopic and molecular dynamics simulations investigation of the binding mechanism of polybrominated diphenyl ethers to hen egg white lysozyme

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