2020
DOI: 10.1530/eje-19-0750 View full text |Buy / Rent full text
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Abstract: Background Cigarette smoking is a risk factor of osteoporosis and bone fracture. Tobacco smoke contains several polycyclic aromatic hydrocarbons. Thus, we hypothesized that environmental polycyclic aromatic hydrocarbon exposure is associated with bone loss and fracture risk. The present study examined the association between polycyclic aromatic hydrocarbon exposure and bone turnover in the general adult population. Methods A total of 1408 eligible participants from the National Health and Nutrition Examinati… Show more

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“…Furthermore, many studies focusing on cigarette smoking and human stem cells developing into osteoblast have shown that PAHs impact the balance between osteogenesis and osteoclastogenesis. For example, Chen et al (2020) reported that PAH exposure is associated with increased bone resorption among the general adult population in the United States. Similar results have been reported in human mesenchymal stem cells, cells that can differentiate into osteoblasts, exposed to benzo(a)pyrene, in which the PAH exposure suppressed early and late osteogenic differentiation and down-regulated the expression of runt-related transcription factor 2 (Runx2), osteocalcin and osteopontin (An et al, 2020).…”
Section: Mechanisms Of Actionmentioning
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“…Furthermore, many studies focusing on cigarette smoking and human stem cells developing into osteoblast have shown that PAHs impact the balance between osteogenesis and osteoclastogenesis. For example, Chen et al (2020) reported that PAH exposure is associated with increased bone resorption among the general adult population in the United States. Similar results have been reported in human mesenchymal stem cells, cells that can differentiate into osteoblasts, exposed to benzo(a)pyrene, in which the PAH exposure suppressed early and late osteogenic differentiation and down-regulated the expression of runt-related transcription factor 2 (Runx2), osteocalcin and osteopontin (An et al, 2020).…”
Section: Mechanisms Of Actionmentioning
“…PAH exposure causes various systemic diseases, including cancer, obstructive lung diseases, and cardiovascular diseases [ 27 29 ]. Recently, PAH exposure was suggested to be associated with frailty, including poor muscle strength and altered bone turnover in elder population [ 30 , 31 ]. PAHs exposure may have adverse impact on aging process by accelerating DNA methylation aging [ 32 ].…”
Section: Introductionmentioning
“…High levels of PAHs are often detected in a variety of soils [ 3 ]. Some experimental studies have confirmed that cigarettes also contain a variety of PAHs; inhalation causes its metabolites to participate in their absorption in bone, leading to osteoporosis, bone loss, and fracture [ 4 ]. In recent years, research on PAHs has focused on the dynamics of meat or cooking conditions because the formation and inhibition mechanisms of meat are related to the involvement of free radicals which are affected by heating temperature and time, fat precursors, antioxidants, and the presence of water in the meat model system [ 5 ].…”
Section: Introductionmentioning