Association between placenta accreta spectrum and third‐trimester serum levels of vascular endothelial growth factor, placental growth factor, and soluble Fms‐like tyrosine kinase‐1: A meta‐analysis

Alzoubi, Osama; Maaita, Ward; Madain, Zaid; Alzoubi, Mohammad; Sweis, Jaleel Jerry G.; Arar, Ahmad; Sweis, Nabil William G.

doi:10.1111/jog.15330

Cited by 5 publications

(2 citation statements)

References 47 publications

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“…Therefore, genetically modified animal models based on the current understanding of molecular biological processes involved in the abnormal vascular remodeling of PAS will also become one of the paths to establish new PAS. For example, VEGF-targeted gene editing has been found to be an essential regulator in the placental vascular abnormalities of PAS ( 73 , 120 , 121 ).…”

Section: Approaches To Establish the Pas Modelmentioning

confidence: 99%

Animal models of the placenta accreta spectrum: current status and further perspectives

2023

Front. Endocrinol.

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Placenta accreta spectrum disorder (PAS) is a kind of disease of placentation defined as abnormal trophoblast invasion of part or all of the placenta into the myometrium, even penetrating the uterus. Decidual deficiency, abnormal vascular remodeling in the maternal–fetal interface, and excessive invasion by extravillous trophoblast (EVT) cells contribute to its onset. However, the mechanisms and signaling pathways underlying such phenotypes are not fully understood, partly due to the lack of suitable experimental animal models. Appropriate animal models will facilitate the comprehensive and systematic elucidation of the pathogenesis of PAS. Due to the remarkably similar functional placental villous units and hemochorial placentation to humans, the current animal models of PAS are based on mice. There are various mouse models induced by uterine surgery to simulate different phenotypes of PAS, such as excessive invasion of EVT or immune disturbance at the maternal–fetal interface, which could define the pathological mechanism of PAS from the perspective of the “soil.” Additionally, genetically modified mouse models could be used to study PAS, which is helpful to exploring the pathogenesis of PAS from the perspectives of both “soil” and “seed,” respectively. This review details early placental development in mice, with a focus on the approaches of PAS modeling. Additionally, the strengths, limitations and the applicability of each strategy and further perspectives are summarized to provide the theoretical foundation for researchers to select appropriate animal models for various research purposes. This will help better determine the pathogenesis of PAS and even promote possible therapy.

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Section: Approaches To Establish the Pas Modelmentioning

confidence: 99%

Animal models of the placenta accreta spectrum: current status and further perspectives

2023

Front. Endocrinol.

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“…The sFlt-1 was significantly decreased and not dependent on the type of PAS, and these results were consistent among studies. A suitable cut-off value has to be established to include these promising findings in clinical practice [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review

Modzelewski

Siarkowska

Pajurek-Dudek

et al. 2023

IJMS

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This systematic review was conducted to gather evidence of preeclampsia occurring before the 20th week of gestation, additionally considering the role of PLGF and sFlt-1 in the development of the disease. In the three cases of preeclampsia before the 20th week of gestation presented in the authors’ material, all pregnancies ended up with IUFD, and the SFlt-1/PLGF ratios were significantly elevated in all women. Eligible publications were identified with searches in the PubMed, Embase, Scopus, and Web of Science databases. No date or language restrictions were made. All original peer-reviewed scientific reports were included. A total of 30 publications were included in the final report, including case reports and case series. No other publication types regarding this issue were identified. In the literature, 34 cases of preeclampsia with onset occurring before the 20th week of gestation were identified, for a final total of 37 cases. Live births were reported in 5 cases (10.52%), and there were 9 intrauterine fetal demises (24.32%), and 23 terminations of pregnancy (62.16%). Preeclampsia before the 20th week of gestation is rare but can occur. We collected all available evidence regarding this phenomenon, with 37 cases reported worldwide. We call for large-scale cohort or register-based studies to establish revised definitions or develop new ones regarding the currently unrecognized very early onset preeclampsia.

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Placenta Accreta Spectrum

Bhaskaran

Radhika

2023

Labour and Delivery

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Association between placenta accreta spectrum and third‐trimester serum levels of vascular endothelial growth factor, placental growth factor, and soluble Fms‐like tyrosine kinase‐1: A meta‐analysis

Cited by 5 publications

References 47 publications

Animal models of the placenta accreta spectrum: current status and further perspectives

Animal models of the placenta accreta spectrum: current status and further perspectives

Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review

Placenta Accreta Spectrum

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