Association between periodontal disease and chronic obstructive pulmonary disease

Lin, Peiya; Liu, Anhao; Tsuchiya, Yosuke; Noritake, Kanako; Ohsugi, Yujin; Toyoshima, Keita; Tsukahara, Yuta; Shiba, Takahiko; Nitta, Hiroshi; Aoki, Akira; Iwata, Takanori; Katagiri, Sayaka

doi:10.1016/j.jdsr.2023.10.004

Cited by 2 publications

(3 citation statements)

References 118 publications

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“…Indeed, dentists and physicians should monitor and increase awareness among COPD patients on oral hygiene, not only for prevention of periodontal diseases, but also to potentially slow COPD progression (Subbappa et al., 2023 ). This notion is supported by interventional studies indicating that periodontal treatment may effectively improve COPD symptoms (Lin, Liu, et al., 2023 ).…”

Section: Smoking and Oral Health Shape The Airway Microbiome Through ...mentioning

confidence: 79%

“…It affects tooth‐supporting tissues and is linked to pulmonary diseases. Epidemiological studies across various countries and regions indicate a positive correlation between the prevalence and severity of periodontitis with the onset and progression of COPD (Kelly et al., 2021 ; Lin, Liu, et al., 2023 ; Subbappa et al., 2023 ; Suzuki, Kamio, Kaneko, et al., 2022 ; Suzuki, Kamio, Sugimoto, et al., 2022 ; Vollmer et al., 2022 ). Advanced periodontal disease may lead to epithelial damage of the lower airways by inflammatory cytokine release in response to metabolites excreted by periodontal pathogens, which attracts inflammatory cells and subsequent release of metalloproteinases, contributing to COPD progression and exacerbations (Mammen et al., 2020 ; Natalini et al., 2023 ); mechanisms by which periodontitis affects COPD progression are under investigation (Xiong et al., 2024 ).…”

Section: Smoking and Oral Health Shape The Airway Microbiome Through ...mentioning

confidence: 99%

“…Such an index could also be expanded towards personalized chronic disease prognostics as predictors of disease trajectory when applied longitudinally over time to COPD patients. In addition, the frequency of lung function decline and exacerbation in COPD patients with periodontitis is more serious than in those with good periodontal health (Kouanda et al., 2021 ; Lin, Liu, et al., 2023 ; Subbappa et al., 2023 ). Thus, integrating the oral–lung axis as a single niche with inter‐connected microenvironments may take multi‐omics microbiome studies into a next level, towards establishing more robust clinically meaningful interactions between exposure, microbial dysbiosis and disease outcomes.…”

Section: Challenges and Opportunities Of The Oral–lung Axis Microbiom...mentioning

confidence: 99%

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Environmental exposures, the oral–lung axis and respiratory health: The airway microbiome goes on stage for the personalized management of human lung function

Garmendia,

Cebollero‐Rivas

2024

Microbial Biotechnology

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The human respiratory system is constantly exposed to environmental stimuli, sometimes including toxicants, which can trigger dysregulated lung immune responses that lead to respiratory symptoms, impaired lung function and airway diseases. Evidence supports that the microbiome in the lungs has an indispensable role in respiratory health and disease, acting as a local gatekeeper that mediates the interaction between the environmental cues and respiratory health. Moreover, the microbiome in the lungs is intimately intertwined with the oral microbiome through the oral–lung axis. Here, we discuss the intricate three‐way relationship between (i) cigarette smoking, which has strong effects on the microbial community structure of the lung; (ii) microbiome dysbiosis and disease in the oral cavity; and (iii) microbiome dysbiosis in the lung and its causal role in patients suffering chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and mortality worldwide. We highlight exciting outcomes arising from recently established interactions in the airway between environmental exposures, microbiome, metabolites–functional attributes and the host, as well as how these associations have the potential to predict the respiratory health status of the host through an airway microbiome health index. For completion, we argue that incorporating (synthetic) microbial community ecology in our contemporary understanding of lung disease presents challenges and also rises novel opportunities to exploit the oral–lung axis and its microbiome towards innovative airway disease diagnostics, prognostics, patient stratification and microbiota‐targeted clinical interventions in the context of current therapies.

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Section: Smoking and Oral Health Shape The Airway Microbiome Through ...mentioning

confidence: 79%

Section: Smoking and Oral Health Shape The Airway Microbiome Through ...mentioning

confidence: 99%

Section: Challenges and Opportunities Of The Oral–lung Axis Microbiom...mentioning

confidence: 99%

See 1 more Smart Citation

Environmental exposures, the oral–lung axis and respiratory health: The airway microbiome goes on stage for the personalized management of human lung function

Garmendia,

Cebollero‐Rivas

2024

Microbial Biotechnology

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The impact of oral diseases on respiratory health and the influence of respiratory infections on the oral microbiome

Gupta,

Saleena,

Kannan

et al. 2024

Journal of Dentistry

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Association between periodontal disease and chronic obstructive pulmonary disease

Cited by 2 publications

References 118 publications

Environmental exposures, the oral–lung axis and respiratory health: The airway microbiome goes on stage for the personalized management of human lung function

Environmental exposures, the oral–lung axis and respiratory health: The airway microbiome goes on stage for the personalized management of human lung function

The impact of oral diseases on respiratory health and the influence of respiratory infections on the oral microbiome

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