Association between obesity measured by different parameters and severity of psoriasis

Duarte, Gleison Vieira; Oliveira, Maria de Fátima Santos Paim de; Cardoso, Thiago M.; Follador, Ivonise; Silva, Thadeu S.; Cavalheiro, Carolina M. Alves; Nonato, Walker; Carvalho, Edgar M.

doi:10.1111/j.1365-4632.2011.05270.x

Cited by 44 publications

(41 citation statements)

References 21 publications

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“…Obezite ve psoriasis ilişkisi ile ilgili çok sayıda çalışma yapılmıştır. Bazı çalışmalarda obezite, psoriasis şiddeti ile ilişkili bulunurken bazılarında ilişkisiz olarak bulunmuştur [10][11][12][13][14][15][16][17] . Sunduğumuz çalışmada obezite ve psoriasis şiddeti zayıf ilişkili olarak tespit edilmiştir.…”

Section: Discussionunclassified

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Body mass index and psoriasis area and severity index relation in Turkish psoriasis population

Özkaya¹,

Onsun²,

Topukcu³

et al. 2014

TURKDERM

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Background and Design:Psoriasis is a chronic immune-mediated inflammatory disease affecting 1-3% of the general population. Recently, it has been suggested that chronic inflammation in psoriasis may cause metabolic and vascular disorders. Most of recent studies focused on the comorbidities and the mechanisms of comorbidities associated with psoriasis. Obesity may lead to cardiovascular disorders, diyabetes mellitus, hypertension, malignancies, musculoskeleteal system diseases, impaired quality of life, and death. In this study, we aimed to investigate the prevalence of obesity in patients with psoriasis and the relationship between the disease severity and body mass index (BMI) in Turkish psoriasis population. Materials and Methods:The patients who attended the Dermatovenerology outpatient clinics at Bezmialem Vakıf University Medical Faculty between February 2007 and March 2013 were enrolled in the study. We retrospectively evaluated the medical records of the patients obtained from the PSR-TR psoriasis follow-up system. Results: Five hundred forty-five women and 474 men were included in the study. The mean age of the female and male patients was 41.3 years, 43.3 years, respectively. The mean body mass index of the patients was 27.5 (26.7 for men and 28.2 for women). 54.6% of obese patients had a psoriasis area and severity index (PASI) score of less than 5, 20.5% had PASI scores between 5-10 and 24.8% had a PASI score of more than 10. Conclusion: In our study, there was a poor relationship between obesity and severity of psoriasis. The prevalence of obesity in psoriasis patients was similar to that in the Turkish population. (Turkderm 2014; 48: 127-30)

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Section: Discussionunclassified

“…Duarte ve ark. 12 Brezilya'da yaptıkları çalışmada (296 hasta) psoriasisli hastalarda obezite sıklığını toplumdan daha yüksek oranda saptamışlar, hastalık şiddetinin obezite ile ilişkili olduğunu gözlemlemişlerdir. Bardazzi ve ark.…”

Section: Discussionunclassified

Body mass index and psoriasis area and severity index relation in Turkish psoriasis population

Özkaya¹,

Onsun²,

Topukcu³

et al. 2014

TURKDERM

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“…waist circumference -WC), wskaźnik talia-biodra (ang. waist-hip ratio -WHR) a wskaźnikiem PASI [31]. Zaobserwowano także, że redukcja masy ciała powoduje lepszą odpowiedź na stosowane leczenie ogólnoustrojowe, natomiast operacje bariatryczne wpływają na znaczną redukcję parametrów ciężkości łuszczycy [32,33].…”

Section: Otyłośćunclassified

Psoriasis as a risk factor of cardiovascular diseases

Komorowska¹,

Szczerkowska-Dobosz²,

Purzycka-Bohdan³

et al. 2014

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StreSzczenieŁuszczyca jest przewlekłą chorobą zapalną skóry związaną z nadmierną proliferacją naskórka. U podłoża zmian skórnych leży współdziałanie czynników genetycznych, immunologicznych i środowiskowych. Do niedawna łuszczyca była uznawana za chorobę dotyczącą wyłącznie skóry. Badania ostatniej dekady wskazują, że jest ona schorzeniem ogól-noustrojowym, które wiąże się ze zwiększoną zapadalnością na liczne choroby, w tym serca i naczyń. Uważa się, że za ten stan odpowiada przewlekły proces zapalny będący elementem patogenezy zarówno łuszczycy, jak i zmian naczyniowych. Wykazano, że u osób z łuszczycą częściej niż w populacji ogólnej występuje nadciśnienie tętnicze, miaż-dżyca, dyslipidemia, cukrzyca i otyłość. Istotne znaczenie dla ryzyka rozwoju chorób układu krążenia ma nieprawidłowy styl życia chorych wynikający m.in. ze znacznego stopnia stygmatyzacji społecznej. Ze względu na zwiększone ryzyko sercowo-naczyniowe chorzy na łusz-czycę wymagają wielospecjalistycznej opieki medycznej oraz działań prewencyjnych, m.in. badań obrazowych serca i naczyń krwionośnych. AbStrActPsoriasis is a chronic inflammatory skin disease associated with increased proliferation of the epidermis. Combination of genetic, immunological and environmental factors underlies the skin lesion. Until recently, psoriasis has been conceived as a skin limited disorder. Studies during the last decade revealed that psoriasis is a systemic disease which is associated with increased incidence of a many conditions, including cardiovascular diseases. It is considered that chronic inflammation, which is part of the pathogenesis of both psoriasis and vascular diseases, is responsible for it. It has been shown that psoriatic patients more often than in the general population have hypertension, atherosclerosis, dyslipidemia, diabetes and obesity. Abnormal life style of patients with psoriasis, resulting, inter alia, in social stigmas, is important for the cardiovascular risk. Because of increased cardiovascular risk factors, patients with psoriasis require interdisciplinary medical care and prevention -imaging studies of the heart and blood vessels.Łuszczyca jako czynnik ryzyka rozwoju chorób serca i naczyń czynniki ryzyka, łuszczyca, choroby sercowo-naczyniowe.

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“…However, obesity may have a triggering role and may predispose to psoriasis. Chronic pro-inflammatory status, increased adipose tissue and increased body weight due to obesity, increase the risk of psoriasis [10][11][12] . The metaphor of chicken/egg relationship is used due to this close relationship between psoriasis and accompanying metabolic comorbidities 13 .…”

Section: Obesitymentioning

confidence: 99%

Comorbidities in psoriasis: The recognition of psoriasis as a systemic disease and current management

Kalkan¹

2017

TURKDERM

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©Copyright 2017 by Turkish Society of Dermatology and Venereology Turkderm-Turkish Archives of Dermatology and Venereology published by Galenos Yayınevi. Öz IntroductionPsoriasis, with a worldwide prevalence of 2-3%, is now assumed as a systemic chronic inflammatory disease accompanied by comorbidities while it was accepted as a disease limited only to the skin in the past 1 . Psoriasis and its comorbidities were the main focused topic at several sessions of the 73 rd Annual Meeting of the American Academy of Dermatology and, especially, systemic disease concept was emphasized 2 . Therefore, recent publications suggest that the term psoriatic disease would be a better nomination instead of psoriasis 3 . In this review, learning screening recommendations developed for early detection and treatment of comorbidities as well as integrated, multidisciplinary approach for disease management have been targeted by reviewing psoriasis and accompanying comorbidities. Comorbidities are more frequently seen in 15% of psoriasis patients who have moderate to severe psoriasis due to increased inflammatory impact and common pathogenesis. Consistent monitoring and systemic treatment are required to prevent development of comorbidities. There are several Tüm dünyada %2-3 oranında görülme sıklığına sahip psoriazis, geçmişte sadece deriye sınırlı kabul edilirken, günümüzde birçok komorbiditenin eşlik ettiği kronik sistemik enflamatuvar bir hastalık olarak ele alınmaktadır. Orta-şiddetli düzeyde psoriazisi olanlarda daha sık görülen komorbiditelerle ilgili çeşitli sınıflamalar mevcuttur. Basit olarak klasik, kronik sistemik enflamasyonla ilişkili, yaşam tarzı ile ilgili ve tedavi ile ilgili olarak sınıflanabileceği gibi medikal komorbiditeler, psikiyatrik/psikolojik komorbiditeler ve komorbiditelere katkı yapan durumlar şeklinde de sınıflanabilmektedir. Bu derlemede psoriazis ve eşlik eden komorbiditelerin gözden geçirilmesiyle; komorbiditelerin erken tanı ve tedavisini sağlama, komorbiditilerin erken tespitine yönelik geliştirilen tarama önerilerini öğrenme ve hastalığın yönetiminde entegre, multidisipliner yaklaşım ile uzun dönem hastalık kontrolü ve hayat kalitesinde düzelme sağlamak hedeflenmektedir. Anahtar Kelimeler: Psoriazis, komorbidite, sistemik hastalık Psoriasis, with a worldwide prevalence of 2-3%, is now assumed as a systemic chronic inflammatory disease accompanied by comorbidities while it was accepted as a disease limited only to the skin in the past. There are several classifications of the comorbidities which are more common in patients with moderate to severe psoriasis. Simply, comorbidities can be classified as classic, emerging, related to lifestyle, related to treatment. They can also be categorized as medical comorbidities, psychiatric/psychologic comorbidities, and behaviors contributing to medical and psychiatric comorbidities. In this review, providing early diagnosis and treatment of comorbidities, learning screening recommendations for early detection and long-term disease control and improvemen...

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Association between obesity measured by different parameters and severity of psoriasis

Abstract: This study extends previous reports of an association between psoriasis and obesity and shows a direct correlation between obesity as measured according to different parameters and psoriasis severity.

Cited by 44 publications

References 21 publications

Body mass index and psoriasis area and severity index relation in Turkish psoriasis population

Body mass index and psoriasis area and severity index relation in Turkish psoriasis population

Psoriasis as a risk factor of cardiovascular diseases

Comorbidities in psoriasis: The recognition of psoriasis as a systemic disease and current management

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