Association between novel inflammatory markers derived from hemogram indices and metabolic parameters in type 2 diabetic men

Bilgin, Satılmış; Aktas, Gülali; Koçak, Mehmet Zahid; Tel, Burçin Meryem Atak; Kurtkulağı, Özge; Duman, Tuba Taslamacıoğlu; Şavlı, Haluk

doi:10.1080/13685538.2019.1632283

Cited by 85 publications

(83 citation statements)

References 26 publications

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“…[5][6][7][8] Blood parameters such as neutrophils, lymphocytes, and platelets can derange and influence their respective ratios, which were found to be predictors with diagnostic accuracy in AD, AIS, and other diseases. 5,7,[9][10][11] Among them, NLR and LMR are potential inflammatory biomarkers which have recently been reported as important predictors of overall survival in patients with tumor, intracerebral hemorrhage, or acute ischemic stroke. [12][13][14][15][16] They are easily acquired blood markers through routine complete blood counts (CBC), posing little risk, or burden to the patient.…”

Section: Introductionmentioning

confidence: 99%

“…Studies show systemic inflammatory response will push forward an immense influence on the progression and outcome of AIS and aortic dissection(AD) 5‐8 . Blood parameters such as neutrophils, lymphocytes, and platelets can derange and influence their respective ratios, which were found to be predictors with diagnostic accuracy in AD, AIS, and other diseases 5,7,9‐11 . Among them, NLR and LMR are potential inflammatory biomarkers which have recently been reported as important predictors of overall survival in patients with tumor, intracerebral hemorrhage, or acute ischemic stroke 12‐16 .…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic performances of neutrophil to lymphocyte ratio and lymphocyte to monocyte ratio in acute ischemic stroke caused by cervicocranial arterial dissection

Sun

Diao

et al. 2020

Clinical Laboratory Analysis

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Background Inflammation plays an important role in the initiation and progression of cervicocranial arterial dissection (CCAD). New inflammatory indices derived from full cell blood count may be associated with increased risk of acute ischemic stroke (AIS) caused by CCAD. The goal of this study is to evaluate the diagnostic performances of neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ratio (LMR) in CCAD. Method We retrospectively analyzed 52 patients with AIS caused by CCAD from emergency room (group I), 51 patients with CCAD from emergency room or clinic(group II) and 52 controls (group III), age and sex matched. Data were collected on the admission including NLR and LMR. Results Neutrophil to lymphocyte ratio and LMR have significant differences among three groups, especially in group I vs both groups II and III (P < .001). There was a negative correlation between admission NLR and LMR. Low LMR level and high NLR level may be associated with severity of AIS caused by CCAD and significantly predict AIS in CCAD. The area under the curve of NLR and LMR were 0.77 and 0.71, respectively, on receiver operating characteristic curve analysis. The optimal cutoff values of NLR and LMR that best discriminated AIS were 2.35 (81% sensitivity and 63% specificity) and 3.67 (64% sensitivity and 77% specificity). Conclusions Neutrophil to lymphocyte ratio neutrophil to lymphocyte ratio and LMR may contribute to the diagnostic evaluation and prompt immediate therapy in patients with CCAD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diagnostic performances of neutrophil to lymphocyte ratio and lymphocyte to monocyte ratio in acute ischemic stroke caused by cervicocranial arterial dissection

Sun

Diao

et al. 2020

Clinical Laboratory Analysis

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“…Six of the thirty-four patients in our study had type-2 DM. Bilgin et al (17) studied NLR, PLR, RDW in their recent study about male patients with type-2 DM. They have found strong relations between these hemogram parameters with hemoglobin A1C.…”

Section: Figure 2 Roc Curve For Platelet/lymphocyte Ratio (Plr)mentioning

confidence: 99%

The Relationship Between Platelet/Lymphocyte and Neutrophil/Lymphocyte Ratios and Mortality in Intensive Care Patients with Crimean-Congo Hemorrhagic Fever

Avcı¹

2020

Erciyes Med J

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This study aims to examine the platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR) values in predicting mortality of Crimean-Congo Hemorrhagic Fever (CCHF) patients in an intensive care unit (ICU). Materials and Methods: This is a retrospective study, and 34 patients diagnosed with CCHF hospitalized in ICU between 1 January 2016-1 January 2020 were included in this study. Demographic data and PLR, NLR, mean platelet volume (MPV), red cell distribution width (RDW), c-reactive protein (CRP) values in their first blood samples taken in ICU were analyzed. Receiver operating characteristic (ROC) curve analyses for the estimation value of the parameters was carried out. The area under the curve (AUC), sensitivity and specificity were used to evaluate the performance of the diagnostic tests. Results: The mortality rate was 52% (18 exitus). The average length of ICU stay was 10.8±6.6 days. For the value of 8.40 FL for MPV, sensitivity was 83.3%, and specificity was 68.8%. The sensitivity was 88.9% and the specificity was 81.3% for the value of 13.15% of RDW. For NLR, the sensitivity was 83.3%; and the specificity was 87.5% for the value of 2.73. For PLR, the sensitivity was 81.3%, and the specificity was 100% for the cutoff value of 49.94. Conclusion: PLR and NLR can give the physician an idea about the mortality in patients with severe CCHF; however, studies with a larger number of patients are needed for full validity.

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“…Recently, the indices derived from CBC are recognized as novel inflammatory markers and predictors of outcome in chronic inflammatory diseases [6] and risk predictor for coronary heart disease [7].…”

Section: Introductionmentioning

confidence: 99%

Hematological Inflammatory Markers in patients with clinically confirmed familial hypercholesterolemia

Vaseghi

Heshmat-Ghahdarijani

Shafiee

et al. 2020

Preprint

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Background and aims:Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder of lipid metabolism which leads to premature cardiovascular diseases. In patients with FH, blood inflammatory markers may be disrupted; however, its extent is unclear. In this study we aimed to evaluate, the NLR: Neutrophil to lymphocyte ratio, PLR: Platelet count to lymphocyte count ratio, MPV: Mean platelet volume, RPR: Red blood cell distribution width to platelet count ratio, WBC: White blood cell, PDW: Platelet distribution width and platelets count. Methods:The study group consisted of 331 patients with FH and 260 control patients. Controls had a history of hyperlipidemia and both groups could be on pharmacotherapy or not. Results:None of the CBC inflammatory markers were not significantly difference in patients with FH than non-FH. Platelet count was significantly higher among patients with FH when compared to control patients (240.43±54.15 vs 228.52±47.37 p= 0.049*). When we used linear regression analysis, only RLR was independently associated with total cholesterol (b=0.000, p=0.13). Here we showed that CBC markers are nor different between FH and non-FH patients, however PLR is associated with cholesterol level not FH. Conclusions:Our results may show the important of high cholesterol on platelets activity and highlight the use of lipid lowering drugs in patients with hyperlipidemia.

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Association between novel inflammatory markers derived from hemogram indices and metabolic parameters in type 2 diabetic men

Cited by 85 publications

References 26 publications

Diagnostic performances of neutrophil to lymphocyte ratio and lymphocyte to monocyte ratio in acute ischemic stroke caused by cervicocranial arterial dissection

Diagnostic performances of neutrophil to lymphocyte ratio and lymphocyte to monocyte ratio in acute ischemic stroke caused by cervicocranial arterial dissection

The Relationship Between Platelet/Lymphocyte and Neutrophil/Lymphocyte Ratios and Mortality in Intensive Care Patients with Crimean-Congo Hemorrhagic Fever

Hematological Inflammatory Markers in patients with clinically confirmed familial hypercholesterolemia

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