Association between non-HDL-C/HDL-C ratio and carotid atherosclerosis in postmenopausal middle-aged women

Masson, Walter; Epstein, Teo; Huerín, Melina; Lobo, Martín; Molinero, Graciela; Siniawski, Daniel

doi:10.1080/13697137.2019.1631787

Cited by 18 publications

(17 citation statements)

References 25 publications

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“…The present study provides further evidence that the non-HDLc/HDLc was also positively correlated with the presence of carotid plaques. In addition, this study extends previous work on associations of the non-HDLc/HDLc with carotid plaques from postmenopausal middle-aged females [15] to the case of a high stoke risk population.…”

Section: Discussionsupporting

confidence: 78%

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Relationship between the non-HDLc-to-HDLc ratio and carotid plaques in a high stroke risk population: A cross-sectional study in China

Liu

Zhang

Xia

et al. 2020

Preprint

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Background: Evidence on the association between the non-high-density lipoprotein cholesterol (non-HDLc)-to-high-density lipoprotein cholesterol (HDLc) ratio (non-HDLc/HDLc) and carotid plaques is still limited. This study aims to assess the relationship between the non-HDLc/HDLc and carotid plaques in a population with a high risk of stroke.Methods: A cross-sectional study based on the community was conducted in Yangzhou, China. Residents (no younger than 40 years old) underwent questionnaire interviews, physical examinations, and laboratory testing during 2013-2014. The subjects with a high risk of stroke were further selected (at least three of eight risk factors including hypertension, atrial fibrillation, type 2 diabetes mellitus, dyslipidaemia, smoking, lack of exercise, overweight, and family history of stroke) or a transient ischaemic attack (TIA) or stroke history. Carotid ultrasonography was then performed on the high stroke risk participants. Carotid plaque was defined as a focal carotid intima-media thickness (cIMT) ≥1.5 cm or a discrete structure protruding into the arterial lumen at least 50% of the surrounding cIMT. Logistic regression was employed to evaluate the relationship between the non-HDLc/HDLc and carotid plaques.Results: Overall, 839 subjects with a high risk of stroke were ultimately included in the analysis, and carotid plaques were identified in 341 (40.6%) of them. Participants in the highest non-HDLc/HDLc tertile group presented a higher proportion of carotid plaques than did those in the other two groups. After adjustment for other confounders, each unit increase in the non-HDLc/HDLc was significantly associated with carotid plaques (OR 1.55, 95%CI 1.28-1.88). In the subgroup analysis, the non-HDLc/HDLc was positively and significantly associated with the presence of carotid plaques in most subgroups. Additionally, the non-HDLc/HDLc interacted significantly with three stratification variables, including sex (OR 1.31 for males vs. OR 2.37 for females, P interaction = 0.016), exercise (OR 1.18 for subjects without lack of exercise vs. OR 1.99 for subjects with lack of exercise, P interaction = 0.004) and heart diseases (OR 1.40 for subjects without heart diseases vs. OR 3.12 for subjects with heart diseases, P interaction = 0.033). Conclusion: The non-HDLc/HDLc was positively associated with the presence of carotid plaques in a Chinese high stroke risk population. A prospective study or randomized clinical trial of lipid-lowering therapy in the Chinese population is needed to evaluate their causal relationship.

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Section: Discussionsupporting

confidence: 78%

“…postmenopausal females with a higher non-HDLc/HDLc were more likely to have carotid plaques [15]. However, the relationship between the non-HDLc/HDLc and carotid plaques is still largely unexplored in different populations.…”

mentioning

confidence: 99%

Relationship between the non-HDLc-to-HDLc ratio and carotid plaques in a high stroke risk population: A cross-sectional study in China

Liu

Zhang

Xia

et al. 2020

Preprint

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“…Non-HDL-C/HDL-C may correlate better with CVD risk than LDL-C and non-HLD-C levels [34]. Similar to the TG/HDL-C ratio associations of high non-HDL-C/HDL-C ratios were reported with CVD in the general population [19,35], with insulin resistance [36], and with CKD in an adult Chinese population [15]. Furthermore, we found low level of iPTH was associated with poor prognosis, which was consistent with Avram's study [37].…”

Section: Discussionmentioning

confidence: 79%

Elevated TG/HDL-C and non-HDL-C/HDL-C ratios predict mortality in peritoneal dialysis patients

et al. 2020

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Background and aims: Dyslipidemia is common in patients with chronic kidney disease and particular prevalent in patients receiving peritoneal dialysis. However, whether markers of atherogenic dyslipidemia correlate with outcomes in dialysis patients as in the general population is uncertain. The aim of this study was to explore the prognostic value of the serum triglyceride/HDL cholesterol (TG/HDL-C) ratio and non-HDL-C/HDL-C ratio to predict mortality in peritoneal dialysis patients. Methods: Two hundred fourteen peritoneal dialysis patients were retrospectively analyzed from January 2011 to December 2015, with a median follow-up of 59 months. We used receiver operating curves (ROC) to determine the optimal threshold for TG/HDL-C and non-HDL/HDL-C ratios at baseline to predict overall survival during follow-up. Prognostic values were accessed by univariate and multivariate COX regression analysis and Kaplan-Meier curve. A predictive nomogram was developed to predict prognosis for overall survival, and the predictive accuracy was evaluated by concordance index (c-index). Results: The optimal cutoff values for TG/HDL-C ratio and non-HDL-C/HDL-C ratio to predict mortality were 1.94 and 2.86, respectively. A high TG/HDL-C ratio and a high non-HDL-C/HDL-C ratio strongly correlated with worse overall survival in peritoneal dialysis patients. Multivariate analysis demonstrated that elevated TG/HDL-C ratio (HR 3.57, 95% CI 1.99, 6.39, P < 0.000) as well as non-HDL/HDL-C ratio (HR 2.58, 95%CI 1.39-4.81, P = 0.003) were independent markers to predict reduced OS. A nomogram was constructed to predict overall survival, with a cindex for predictive accuracy of 0.795. Conclusion: TG/HDL-C ratio and non-HDL-C/HDL-C may serve as potential prognostic biomarkers in PD patients.

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“…Moreover, non-HDL-C/HDL-C ratio is a strong indicator for predicting carotid atherosclerotic plaque in middle-aged postmenopausal women [34]. Besides, for the prediction of risk of cardiovascular diseases, this ratio is similar to the apo B/apo A-I ratio for DM patients [35].…”

Section: The Correlation Between the Apo B/apo A-i Ratio And Icas Wasmentioning

confidence: 88%

Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

Yang

Shen

et al. 2020

Preprint

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Abstract Background: This study aims to investigate the association of lipid ratios with intracranial atherosclerotic stenosis (ICAS) in a Chinese population.Methods: This cross-sectional study included 658 consecutive patients with ischemic stroke. Intracranial and extracranial arteries were evaluated for atherosclerotic stenosis using digital subtraction angiography or computed tomography angiography. Lipid ratios [total cholesterol (TC)/high-density lipoprotein-cholesterol (HDL-C), triglycerides (TG)/HDL-C, low-density lipoprotein-cholesterol (LDL-C)/HDL-C, non-high-density lipoprotein-cholesterol (non-HDL-C)/HDL-C, remnant cholesterol (RC)/HDL-C, apolipoprotein B (apo B)/apolipoprotein A-I (apo A-I), and apo B/HDL-C] were calculated.Results: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C, apo B/HDL-C and apo B/apo A-I ratios (all P <0.05) were significantly associated with ICAS but not with extracranial atherosclerotic stenosis after adjustment for confounding factors. Receiver operating characteristic (ROC) curves analyses revealed that the apo B/apo A-I ratio had the largest area under the ROC curve (AUC) among lipid levels alone and for lipid ratios (AUC = 0.588). Lipid ratios had higher AUC values than those for lipid levels alone for the identification of ICAS.Conclusion: The TC/HDL-C, LDL-C/HDL-C, RC/HDL-C, non-HDL-C/HDL-C apo B/HDL-C, and apo B/apo A-I ratios were significantly related to ICAS risk. Compared with the other variables tested, the apo B/apo A-I ratio appeared to be a better discriminator for identifying ICAS risk in stroke patients.

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Association between non-HDL-C/HDL-C ratio and carotid atherosclerosis in postmenopausal middle-aged women

Cited by 18 publications

References 25 publications

Relationship between the non-HDLc-to-HDLc ratio and carotid plaques in a high stroke risk population: A cross-sectional study in China

Relationship between the non-HDLc-to-HDLc ratio and carotid plaques in a high stroke risk population: A cross-sectional study in China

Elevated TG/HDL-C and non-HDL-C/HDL-C ratios predict mortality in peritoneal dialysis patients

Importance of lipid ratios for predicting intracranial atherosclerotic stenosis

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