Association Between Neutrophil to Lymphocyte Ratio and Inflammatory Markers in Hemodialysis Patients

El-Hafeez, Hafez Ahmed Abd; Alashkar, Ahmed Mohammed; Mohamed, Nagah Mohamed Abo; Khalil, Mohammed I.

doi:10.21608/amj.2020.82567

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…In this study we demonstrated that PLR was negatively correlated with all of serum creatinine, potassium, LDL cholesterol and TIBC, while PLR was significantly correlated with both serum sodium, creatinine clearance and serum ferritin. These findings reflecting association between PLR as a marker for the inflammation and the metabolic derangement in these population that comes in agreement with El-Hafeez et al (19) , Ahmed et al (20) and Grilz et al (21) . Anemia and erythropoietin resistance are two complications of chronic kidney disease, and inflammation is a major risk factor for both.…”

Section: Discussionsupporting

confidence: 90%

“…Also, El-Hafeez et al (19) revealed that patients' PLR was found to have a statistically significant (p 0.05) positive correlation with their Platelet count, and a statistically significant (p 0.05) negative correlation with their Hb and ALC. Additionally, Ahmed et al (20) found that Positive correlations were found between PLR and MCH and PLR and ferritin in the patient group, while negative correlations were seen between PLR and Hb and PLR and ALC.…”

Section: Discussionmentioning

confidence: 94%

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Usefulness of Platelet to Lymphocyte Ratio as a marker of Erythropoietin Resistance in Hemodialysis Patients

ELSheikh¹,

Fathy²,

Azab³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Chronic inflammation was associated with the hyporesponsiveness to erythropoiesis stimulating agents (ESA) in hemodialysis (HD) patients. A rising indicator of inflammation is the platelet-to-lymphocyte ratio (PLR). Objective: The aim of the current work was to assess the role of the PLR in detection of the response to ESA in HD cases. Patients and methods: This cross-sectional study included a total of 80 patients who underwent regular HD at the

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 94%

Usefulness of Platelet to Lymphocyte Ratio as a marker of Erythropoietin Resistance in Hemodialysis Patients

ELSheikh¹,

Fathy²,

Azab³

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…The NLR is a surrogate marker of systemic in ammation and was previously shown to be more strongly associated with mortality than the total WBC count in hemodialysis patients. (8) Many authors have investigated various in ammatory markers such as the platelet to lymphocyte ratio, interleukin 6 (9) , C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-a), interleukin-1-beta (IL-1b) (10), broblast growth factor 23, soluble alpha klotho, indoxyl sulfate, beta-CrossLaps, and Procollagen 1 N-terminal propeptide levels (11) .…”

Section: Introductionmentioning

confidence: 99%

Impact of Ramadan Fasting on Nutrition, Inflammation and Dialysis Adequacy among Hemodialysis Patients

Elnoty,

Elwasif,

Nassar

et al. 2024

Preprint

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Background Fasting the holy month of Ramadan is one of the obligatory rituals in Islam. Although sick people are exempted, some insist on fasting. Several studies concerning safety and its impact on patients with different diseases have been reported. In this context, the hemodialysis population represents a special entity. The present study aimed to assess the impact of fasting on nutritional status, inflammatory status, and the adequacy of hemodialysis. Methods In this prospective cohort study, 65 hemodialysis patients were recruited from the hemodialysis unit in the Urology and Nephrology Center at Mansoura University, Egypt. The participants were divided into three groups based on different intentions to fast during Ramadan. Group 1 included 21 patients who fasted daily (DFG). Group 2 included 25 patients who fasted non-hemodialysis hemodialysis days; we referred to this group as the partial fasting group (PFG). Group 3 included 19 patients who did not fast; these patients composed the nonfasting group (NFG). Nutritional status was assessed using a subjective global assessment (SGA) and triceps skin fold thickness. The neutrophil to lymphocyte ratio (NLR), human B-cell lymphoma/leukemia2 (BCL2), and advanced glycation end products (sRAGE) were used as inflammatory markers. Hemodialysis adequacy was evaluated by KT/V and the urea reduction ratio (URR). All patient assessments were carried out before, immediately after, and 3 months after Ramadan. Results There was a significant reduction in nutritional status in all studied groups (all P <0.05), despite a significant reduction in serum cholesterol and fasting blood sugar levels. The urea reduction ratio (URR) and intradialytic weight gain (IDWG) were the same before and after fasting Ramadan. Kt/V and human soluble receptor for advanced glycation end products (sRAGE) In the RPFG, fasting led to significant reductions (all P < .02) only in the serum albumin concentration and triceps skin fold thickness. There were no significant changes in BMI, URR, cholesterol, FBS, KT/V, IDWG, SGA score, NLR, and BCL2 or sRAGE. In the RNFG, there was a significant reduction (all P<0.02) in triceps skin fold thickness, and a significant change in the SGA score, and in the sRAGE. and BCL2 levels. Conclusion There was no harmful effect for Muslim patients receiving regular HD who wanted to fast with Ramadan on days other than HD session days. In the present study, this particular group benefited from both fasting and insignificant changes in almost all nutritional assessment points, inflammatory markers, and the adequacy of HD. Therefore, our findings suggest that partial Ramadan fasting is tolerable by hemodialysis. patients and is not associated with important clinical complications. They should be closely monitored and instructed to adhere to their dietary and fluid intake allowances.

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Association Between Neutrophil to Lymphocyte Ratio and Inflammatory Markers in Hemodialysis Patients

Cited by 2 publications

References 7 publications

Usefulness of Platelet to Lymphocyte Ratio as a marker of Erythropoietin Resistance in Hemodialysis Patients

Usefulness of Platelet to Lymphocyte Ratio as a marker of Erythropoietin Resistance in Hemodialysis Patients

Impact of Ramadan Fasting on Nutrition, Inflammation and Dialysis Adequacy among Hemodialysis Patients

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