Association between migraine frequency and neural response to emotional faces: An fMRI study

Szabó, Emese; Galambos, Attila; Kocsel, Natália; Édes, Andrea Edit; Pap, Dorottya; Zsombók, Terézia; Kozák, Lajos R.; Bagdy, György; Kökönyei, Gyöngyi; Juhász, Gabriella

doi:10.1016/j.nicl.2019.101790

Cited by 29 publications

(36 citation statements)

References 84 publications

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“…Additionally, we found the combined MDD subtype (which includes participants with both melancholic and atypical characteristics) to be associated with higher migraine frequency independent of migraine subtype. Our results are in accordance with a recent study showing an association between depression symptoms and migraine frequency in patients with both migraine with and without aura (37). However, no information on MDD subtypes was available in this study.…”

Section: Discussionsupporting

confidence: 94%

Major depression subtypes are differentially associated with migraine subtype, prevalence and severity

et al. 2019

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Objective Migraine and major depressive disorder show a high rate of comorbidity, but little is known about the associations between the subtypes of major depressive disorder and migraine. In this cross-sectional study we aimed at investigating a) the lifetime associations between the atypical, melancholic, combined and unspecified subtype of major depressive disorder and migraine with and without aura and b) the associations between major depressive disorder and its subtypes and the severity of migraine. Methods A total of 446 subjects with migraine (migraine without aura: n = 294; migraine with aura: n = 152) and 2511 controls from the population-based CoLaus/PsyCoLaus study, Switzerland, were included. Associations between major depressive disorder subtypes and migraine characteristics were tested using binary logistic or linear regression. Results Melancholic, combined and unspecified major depressive disorder were associated with increased frequency of migraine with aura, whereas only melancholic major depressive disorder was associated with increased frequency of migraine without aura. Lifetime and unspecified major depressive disorder were associated with severe migraine intensity among subjects with migraine with aura but not migraine without aura, while combined major depressive disorder was associated with higher migraine frequency independently from migraine subtype. Conclusion This study suggests that melancholic but not atypical major depressive disorder is associated with migraine and migraine subtypes. Future studies exploring pathophysiological mechanisms shared between melancholic depression and migraine are warranted.

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Section: Discussionsupporting

confidence: 94%

Major depression subtypes are differentially associated with migraine subtype, prevalence and severity

et al. 2019

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“…This aspect of the migraine cycle shows a surprising symmetry with the fMRI, where the Broadman areas 17–19 of the visual cortex demonstrated a peculiar pattern of activation related to the distance from the migraine attack [ 16 ]. The same cyclic pattern has been shown in sensorimotor and visual cortices by both electrophysiological and neuroimaging studies [ 2 , 3 , 11 , 36 , 38 , 39 ]. Functional neuroimaging or combined electrophysiological techniques could help to discriminate morpho-functional elements.…”

Section: Discussionsupporting

confidence: 71%

Supersaturation of VEP in Migraine without Aura Patients Treated with Topiramate: An Anatomo-Functional Biomarker of the Disease

Luca

Gori

Mazzucchi

et al. 2021

JCM

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Migraine is a primary headache with high prevalence among the general population, characterized by functional hypersensitivity to both exogenous and endogenous stimuli particularly affecting the nociceptive system. The hyperresponsivity of cortical neurons could be due to a disequilibrium in the excitatory/inhibitory signaling. This study aimed to investigate the anatomo-functional pathway from the retina to the primary visual cortex using visual evoked potentials (VEP). Contrast gain protocol was used in 15 patients diagnosed with migraine without aura (at baseline and after 3 months of topiramate therapy) and 13 controls. A saturation (S) index was assessed to monitor the response of VEP’s amplitude to contrast gain. Non-linear nor monotone growth of VEP (S < 0.95) was defined as supersaturation. A greater percentage of migraine patients (53%) relative to controls (7%) showed this characteristic. A strong inverse correlation was found between the S index and the number of days separating the registration of VEP from the next migraine attack. Moreover, allodynia measured through the Allodynia Symptoms Check-list (ASC-12) correlates with the S index both at baseline and after 3 months of topiramate treatment. Other clinical characteristics were not related to supersaturation. Topiramate therapy, although effective, did not influence electrophysiological parameters suggesting a non-intracortical nor retinal origin of the supersaturation (with possible involvement of relay cells from the lateral geniculate nucleus). In conclusion, the elaboration of visual stimuli and visual cortex activity is different in migraine patients compared to controls. More data are necessary to confirm the potential use of the S index as a biomarker for the migraine cycle (association with the pain-phase) and cortical sensitization (allodynia).

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“…The insula is well known to participate in migraine [ 34 ], and while the anterior component considered to be involved in autonomic changes and salience [ 53 ], the posterior insula is associated with pain related changes [ 54 ]. In the generalized allodynia group increased subcortical activations were also observed in regions (i.e., amygdala, caudate) associated with altered pain and emotional processing in migraine [ 37 , 55 – 57 ]. Furthermore, the stronger activation of the brainstem in the allodynic state is in line with the notion that the brainstem is likely to contribute to the sensory processing alterations in migraine and might be related to the intensity of allodynia and pain hypersensitivity [ 15 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia

et al. 2021

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In some patients, migraine attacks are associated with symptoms of allodynia which can be localized (cephalic) or generalized (extracephalic). Using functional neuroimaging and cutaneous thermal stimulation, we aimed to investigate the differences in brain activation of patients with episodic migraine (n = 19) based on their allodynic status defined by changes between ictal and interictal pain tolerance threshold for each subject at the time of imaging. In this prospective imaging study, differences were found in brain activity between the ictal and interictal visits in the brainstem/pons, thalamus, insula, cerebellum and cingulate cortex. Significant differences were also observed in the pattern of activation along the trigeminal pathway to noxious heat stimuli in no allodynia vs. generalized allodynia in the thalamus and the trigeminal nucleus but there were no activation differences in the trigeminal ganglion. The functional magnetic resonance imaging (fMRI) findings provide direct evidence for the view that in migraine patients who are allodynic during the ictal phase of their attacks, the spinal trigeminal nucleus and posterior thalamus become hyper-responsive (sensitized)–to the extent that they mediate cephalic and extracephalic allodynia, respectively. In addition, descending analgesic systems seem as “switched off” in generalized allodynia.

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Association between migraine frequency and neural response to emotional faces: An fMRI study

Cited by 29 publications

References 84 publications

Major depression subtypes are differentially associated with migraine subtype, prevalence and severity

Major depression subtypes are differentially associated with migraine subtype, prevalence and severity

Supersaturation of VEP in Migraine without Aura Patients Treated with Topiramate: An Anatomo-Functional Biomarker of the Disease

Ictal and interictal brain activation in episodic migraine: Neural basis for extent of allodynia

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