Association Between Methylenetetrahydrofolate Reductase Gene Polymorphisms and Risk of Vitiligo: A Systematic Review and Meta-Analysis

Chang, Heng-Chia; Lin, Ming Hsiu; Tsai, Hsiou Hsin

doi:10.2340/00015555-3448

Cited by 2 publications

(1 citation statement)

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“…By conducting a systematic review and meta-analysis of the existing literature, this study seeks to provide a comprehensive understanding of the association between anxiety and autoimmune diseases. The implications of this relationship could extend beyond the realms of psychiatry and immunology, impacting clinical practice, patient care, and treatment approaches [6][7][8][9][10]. As such, identifying potential risk factors and optimizing management strategies for individuals experiencing both anxiety and autoimmune diseases is of paramount importance.…”

Section: Introductionmentioning

confidence: 99%

The Association Between Anxiety and Autoimmune Diseases: A Systematic Review and MetaAnalysis of 16 Studies

2023

J Vaccines Immunol

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This comprehensive systematic review and meta-analysis encompassed 16 studies, involving a total of over 1.4 million participants, to investigate the association between anxiety and autoimmune diseases. The findings revealed a significant association, with individuals experiencing anxiety being 1.28 times more likely to develop autoimmune diseases compared to those without anxiety. The association was found to be stronger in women and individuals with severe anxiety. The study suggests that this association may be due to shared genetic risk factors, the impact of stress on the immune system, and the involvement of inflammation, a common feature of autoimmune diseases. Despite the robust evidence, the study acknowledges limitations such as the use of observational studies and varying study qualities. Future research endeavors should aim to unravel the precise mechanisms underlying the link between anxiety and autoimmune diseases, and account for potential confounding factors. Understanding the association between anxiety and autoimmune diseases has crucial implications for clinical practice. Early recognition of anxiety in individuals with autoimmune diseases can facilitate timely intervention, potentially improving disease outcomes and overall quality of life. A holistic approach to managing both anxiety and autoimmune diseases may lead to more personalized treatment plans and better patient care. In conclusion, the significant association between anxiety and autoimmune diseases highlights the importance of considering psychological factors in the context of autoimmune conditions. By understanding the underlying mechanisms and potential risk factors, healthcare providers can enhance their ability to identify at-risk individuals and implement appropriate management strategies to optimize overall health outcomes in this population. Further research is warranted to explore causality and potential interventions, paving the way for improved prevention and management strategies for individuals with anxiety and autoimmune diseases.

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Section: Introductionmentioning

confidence: 99%

The Association Between Anxiety and Autoimmune Diseases: A Systematic Review and MetaAnalysis of 16 Studies

2023

J Vaccines Immunol

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MTHFR C677T Polymorphism and Serum Homocysteine Level as Risk Factors of Coronary Heart Disease in Patients with Androgenetic Alopecia: A Case Control Study

Saafan

Elsamanoudy

Shaalan

et al. 2021

The American Journal of the Medical Sciences

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Association Between Methylenetetrahydrofolate Reductase Gene Polymorphisms and Risk of Vitiligo: A Systematic Review and Meta-Analysis

Cited by 2 publications

References 13 publications

The Association Between Anxiety and Autoimmune Diseases: A Systematic Review and MetaAnalysis of 16 Studies

The Association Between Anxiety and Autoimmune Diseases: A Systematic Review and MetaAnalysis of 16 Studies

MTHFR C677T Polymorphism and Serum Homocysteine Level as Risk Factors of Coronary Heart Disease in Patients with Androgenetic Alopecia: A Case Control Study

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