Association Between Meteorological Factors and the Rupture of Intracranial Aneurysms

Abstract

BackgroundBoth meteorological factors and morphological factors are important factors to predict intracranial aneurysm rupture. This study investigated the relationship between meteorological factors and aneurysmal subarachnoid hemorrhage (aSAH). Additionally, the morphological differences between ruptured and unruptured aneurysms under these high‐risk meteorological conditions were assessed.Methods and ResultsThe records of 1751 patients with aSAH with 2124 intracranial aneurysms were retrospectively analyzed. Spearman rank correlation analysis was used to assess the risks of incident aSAH on the basis of daily meteorological data. Morphological parameters were analyzed using 1‐way ANOVA tests, and significant parameters (P<0.05) were further examined using a multivariable logistic regression analysis. Daily aSAH incidence had significant negative correlations with daily mean, maximum, and minimum temperature (P<0.001) and a significant positive correlation with daily mean atmospheric pressure (P<0.001). Additionally, 58 patients with multiple aneurysms were assessed to determine morphological differences. There were significant differences in the mean values for aneurysm size, neck width, length, height, width, parent artery diameter, shape of the aneurysm, aspect ratio, size ratio, and bottleneck factor (P<0.05). The multivariable logistic regression analysis showed that aspect ratio (β=1.277, odds ratio=3.585, 95% CI, 1.588–8.090; P=0.002) was an independent risk factor for aneurysm rupture. Receiver operating characteristic curve analysis indicated that the ruptured aneurysm threshold of size was 3.45 mm and aspect ratio was 1.05.ConclusionsLower daily mean, maximum, and minimum temperatures and a higher daily mean atmospheric pressure were associated with an increased rate of aSAH. Additionally, under these meteorological conditions, the aneurysm size and aspect ratio thresholds for predicting rupture of an aneurysm may be lower.

Chronobiological Patterns of Aneurysmal Subarachnoid Hemorrhage in Central China

“…The incidence of aSAH is higher in winter and January/December compared to that in summer and July. Previous clinical studies reported similar results [ 5 11 15 16 17 ]. This circannual pattern could be associated with ambient temperature.…”

“…This circannual pattern could be associated with ambient temperature. Low daily mean, maximum, and minimum temperatures were associated with an increased rate of aSAH [ 11 ]. Another research also reported that temperature decline from the previous day is a trigger for the occurrence of aSAH [ 18 ].…”

“…Previous studies of different races yielded inconsistent results on the diurnal variation of aSAH [ 3 5 6 ]. Most of them were conducted in Western countries, and they lacked subgroup analyses of influencing factors such as age, gender, and hypertension [ 5 6 7 8 9 10 11 ]. The incidence of aSAH onset could be very different among people in distinct cultures for differential lifestyle habits.…”

A Two-Gene-Based Diagnostic Signature for Ruptured Intracranial Aneurysms

“…Previous studies on factors that contribute to an increased risk of rupture of IAs have mainly focused on morphological factors and primary diseases (5,6). Recently, hemodynamic factors, such as the oscillatory shear index, wall shear stress, and blood flow velocity, have been shown to be associated with the formation, progression, and rupture of IAs (7,8). Wall shear stress is regarded as the most important factor for IA initiation and rupture.…”

“…The relationship between morphological factors and the rupture rate of IAs has become a research hot spot. Although many studies have evaluated the relationship between geometric features and IA rupture, there are still great differences (8)(9)(10). In addition, genetic factors have been shown to be closely associated with ruptured IAs, and significant efforts have sought to identify genetic biomarkers for IA rupture (11).…”