Association between interleukin-6 polymorphism in the −174 G/C region and hearing loss in the elderly with a history of occupational noise exposure

Tinnitus is a symptom usually related to cochlear change that may arise from noise exposure and induces expression of proinflammatory cytokines including interleukin-6 (IL6). This study aimed to evaluate the association between the polymorphism of the IL6 gene in the region 174G/C and tinnitus in elderly with history of occupational noise exposure. Settings and Design: This was a cross-sectional study with a sample of 179 independent elderly individuals aged >60 years. Information on exposure to occupational noise was obtained by interviews. Audiological evaluation was performed using pure tone audiometry and genotyped through polymerase chain reaction by restriction fragment length polymorphism (PCR-RFLP). Data were analyzed using the chi-square test and the odds ratio (OR), with the significance level set at 5%. Among the study subjects, 24.6% were homozygous for the G allele, 39.7% were homozygous for the C allele, and 35.8% were heterozygous for IL6 (P > 0.05). Of these, 33.5% reported noise exposure history, with 42.5% having tinnitus. We found significant association between the genotype and allele frequencies of the IL6 −174 gene (rs1800795) and tinnitus among the elderly with history of exposure to occupational noise (P = 0.03). The elderly with the C allele were less likely to have tinnitus associated with history of exposure to occupational noise [OR = 0.167, confidence interval (CI) 95% 0.167-0.749; P = 0.004] when compared to those carrying the G allele. This study suggests that there is an association between polymorphisms in the IL6 gene at region – 174G/C and susceptibility to tinnitus.

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“…[ 28 ] But subsequent findings showed that polymorphism in the IL6 gene should contribute to the risk of NIHL in elderly Brazilians. [ 29 ]…”

Section: Discussionmentioning

confidence: 99%

Association between polymorphism of interleukin-6 in the region -174G/C and tinnitus in the elderly with a history of occupational noise exposure

et al. 2015

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“…This polymorphism affects the constitutive transcription of the interleukin gene by controlling the production 36 . G replaces C and the C allele has a protective function because it is associated with a lower secretion of IL‐6 37 . The CC homozygous causes a lower production of IL‐6 38 .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of IL‐6 levels and +3954 polymorphism of IL‐1β in burning mouth syndrome: A systematic review and meta‐analysis

Campello

Pellizzer

Vasconcelos

et al. 2020

J Oral Pathology Medicine

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This study evaluated IL‐6 salivary levels as well as the +3954 polymorphism of IL‐1β in patients with burning mouth syndrome and healthy individuals, through case‐control studies. This systematic review and meta‐analysis followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. We conducted this research in PubMed/MEDLINE, Cochrane Library and Web of Science databases. The risk of bias was measured based in the Newcastle‐Ottawa Scale. Researches with a group of patients with burning mouth syndrome and a control group in which the presence of the +3954 polymorphism of IL‐1β and/ or IL‐6 salivary levels through non‐stimulated saliva were evaluated to detect if this interleukin concentrations are increased in patients and if the polymorphism is a risk factor for this syndrome. We identified seven studies with total of 440 participants, 229 patients with burning mouth syndrome and 211 healthy controls, ages 24‐84 years old. The female gender was predominant. Patients in the majority of studies did not present increased levels of IL‐6 and the +3954 polymorphism of IL‐1β is not a risk factor for this syndrome. A few studies researched biomarkers in this pathology and more investigations are required not only to identify salivary levels and the polymorphism evaluated, but also other interleukins and polymorphisms in order to clarify the etiopathogenesis of this syndrome as well as for propose new diagnostic methods and treatments.

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“…Especially, the expression of interleukin-6 was higher in spiral ligament, stria vascularis and spiral ganglion. It was suggested that, these cytokines are produced by cochlea against noise trauma; they caused an inflammatory response and played an important role on cochlear damage [25].…”

Section: Methodsmentioning

confidence: 99%

Cochlear Mechanisms in Noise Induced Hearing Loss

Sakat¹,

Berçin²,

Kılıç³

2015

Med-Science

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Association between interleukin-6 polymorphism in the −174 G/C region and hearing loss in the elderly with a history of occupational noise exposure

Abstract: This study suggests there is an association of polymorphisms in the IL-6 gene at position - G174C with susceptibility to noise-induced hearing loss.

Cited by 10 publications

References 26 publications

Association between polymorphism of interleukin-6 in the region -174G/C and tinnitus in the elderly with a history of occupational noise exposure

Association between polymorphism of interleukin-6 in the region -174G/C and tinnitus in the elderly with a history of occupational noise exposure

Evaluation of IL‐6 levels and +3954 polymorphism of IL‐1β in burning mouth syndrome: A systematic review and meta‐analysis

Cochlear Mechanisms in Noise Induced Hearing Loss

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