Association between immunoglobulin G1 againstTannerella forsythiaand reduction in the loss of attachment tissue

Abstract

PurposeTo evaluate whether the levels of immunoglobulin G (IgG) antibody to Tanerella forsythia are associated with periodontal status.MethodsPatients with a diagnosis of chronic periodontitis were considered candidates for the study; thus 80 chronic periodontitis patients and 28 healthy persons (control group) were invited to participate in this investigation. The presence of T. forsythia was detected by polymerase chain reaction (PCR) analysis using primers designed to target the respective 16S rRNA gene sequences. Peripheral blood was collected from each subject to identify the IgG1 and IgG2 serum antibodies against T. forsythia. All microbiological and immunological laboratory processes were completed blindly, without awareness of the clinical status of the study patients or of the periodontal sites tested.ResultsThe bivariate analysis showed that lower mean levels of clinical attachment level (CAL) and probing depth were found in the presence of the IgG1 antibody titers against whole-cell T. forsythia; however, only the difference in CAL was statistically significant. In the presence of the IgG2 antibody titers against whole-cell T. forsythia, the periodontal parameters evaluated were higher but they did not show statistical differences, except for plaque. The unadjusted linear regression model showed that the IgG1 antibody against whole-cell T. forsythia in periodontitis patients was associated with a lower mean CAL (β=-0.654; 95% confidence interval [CI], -1.27 to -0.28; P<0.05). This statistically significant association remained after adjusting for possible confounders (β=-0.655; 95% CI, -1.28 to -0.29; P<0.05). On the other hand, smoking was a statistically significant risk factor in the model (β=0.704; 95% CI, 0.24 to 1.38; P<0.05).ConclusionsSignificantly lower mean levels of CAL were shown in the presence of the IgG1 antibody titers against whole-cell T. forsythia in periodontitis patients. Thus, the results of this study suggest that IgG1 antibody to T. forsythia may have been a protective factor from periodontitis in this sample.Graphical Abstract

Clinical Efficacy of Treatment of Endodontic-Periodontal Lesions: A Systematic Scoping Review of Experimental Studies

“…Unfortunately, in the trials included in this review and as reported in the systematic review by Citterio et al [ 14 ], pocket closure is rarely reported as an outcome. Reporting pocket closure as a result is essential and should be included in future investigations [ 15 ].…”

“…Unfortunately, CAL was poorly evaluated in studies of EPL, which makes it difficult to contrast these results. However, it has been reported that CAL is a parameter that adequately indicates periodontal health [ 15 ]. More clinical trials evaluating CAL in the treatment of EPL are required.…”

Factors Associated with the Extent of Clinical Attachment Loss in Periodontitis: A Multicenter Cross-Sectional Study

“…In this study, P. gingivalis and T. forsythia were associated with advanced CAL. The evidence supports the association of these microorganisms with the progression of periodontal disease [34][35][36][37]. Nevertheless, individuals harboring microorganisms in subgingival plaque generally respond with a humoral immune response against them [38].…”

Variations in IgG antibody subclass responses to oral bacteria: Effects of periodontal disease and modifying factors

“…IgG1 antibody was reported to be elevated to T . forsythia that was related to lower disease measures 49 . In contrast, chronic periodontitis patients showed significantly lower IgG1 and IgG2 antibody to antigens from Capnocytophaga spp 50 .…”