Association between ideal cardiovascular health score trajectories and arterial stiffness: the Kailuan Study

Zhang, Ruiying; Xie, Jinjie; Yang, Renling; Li, Rongjuan; Chong, Mei Sian; Zhang, Mengjie; Chen, Shuohua; Wu, Shouling; Yang, Ya

doi:10.1038/s41440-019-0341-4

Cited by 21 publications

(15 citation statements)

References 35 publications

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“…Atrial stiffness (AS) is one of the earliest types of functional damage that occurs during the vascular ageing process, during which the arterial elasticity decreases and pulse pressure increases [ 40 , 41 ]. Mounting evidence has suggested that AS is a powerful predictor for the future risk of CVDs such as ACS, heart failure (HF), and ischaemic or haemorrhagic stroke [ 42 , 43 ].…”

Section: Tyg Index In Cardiovascular Diseases (Fig 2 ...mentioning

confidence: 99%

Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations

Tao

Wang

et al. 2022

Cardiovasc Diabetol

281

216

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The triglyceride-glucose (TyG) index has been identified as a reliable alternative biomarker of insulin resistance (IR). Recently, a considerable number of studies have provided robust statistical evidence suggesting that the TyG index is associated with the development and prognosis of cardiovascular disease (CVD). Nevertheless, the application of the TyG index as a marker of CVD has not systemically been evaluated, and even less information exists regarding the underlying mechanisms associated with CVD. To this end, in this review, we summarize the history of the use of the TyG index as a surrogate marker for IR. We aimed to highlight the application value of the TyG index for a variety of CVD types and to explore the potential limitations of using this index as a predictor for cardiovascular events to improve its application value for CVD and provide more extensive and precise supporting evidence.

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Section: Tyg Index In Cardiovascular Diseases (Fig 2 ...mentioning

confidence: 99%

Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations

Tao

Wang

et al. 2022

Cardiovasc Diabetol

281

216

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“…Cardiovascular disease (CVD) has climbed to the first cause of death and premature death in China [ 1 , 2 ]. Arterial stiffness, one of the earliest functional damage in the vascular aging process, directly influenced the cardiovascular system by degenerating arterial elasticity and increasing pulse pressure [ 3 , 4 ]. A growing number of studies demonstrated that arterial stiffness was a predictor for future cardiovascular events such as myocardial infarction, unstable angina, heart failure, and ischemic or hemorrhagic stroke [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study

et al. 2021

Cardiovasc Diabetol

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101

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Background Triglyceride–glucose (TyG) index, a simple surrogate marker of insulin resistance, has been reported to be associated with arterial stiffness. However, previous studies were limited by the cross-sectional design. The purpose of this study was to explore the longitudinal association between TyG index and progression of arterial stiffness. Methods A total of 6028 participants were derived from the Kailuan study. TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Arterial stiffness progression was assessed by the annual growth rate of repeatedly measured baPWV. Multivariate linear regression models were used to estimate the cross-sectional association of TyG index with baPWV, and Cox proportional hazard models were used to investigate the longitudinal association between TyG index and the risk of arterial stiffness. Results Multivariate linear regression analyses showed that each one unit increase in the TyG index was associated with a 39 cm/s increment (95%CI, 29–48 cm/s, P < 0.001) in baseline baPWV and a 0.29 percent/year increment (95%CI, 0.17–0.42 percent/year, P < 0.001) in the annual growth rate of baPWV. During 26,839 person-years of follow-up, there were 883 incident cases with arterial stiffness. Participants in the highest quartile of TyG index had a 58% higher risk of arterial stiffness (HR, 1.58; 95%CI, 1.25–2.01, P < 0.001), as compared with those in the lowest quartile of TyG index. Additionally, restricted cubic spline analysis showed a significant dose–response relationship between TyG index and the risk of arterial stiffness (P non-linearity = 0.005). Conclusion Participants with a higher TyG index were more likely to have a higher risk of arterial stiffness. Subjects with a higher TyG index should be aware of the following risk of arterial stiffness progression, so as to establish lifestyle changes at an early stage.

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“…Previous studies aimed to examine the association between long-term patterns in the CVH trajectory and follow-up arterial stiffness. 20–23 These studies showed that attainment of ideal CVH typically declined with age, and higher long-term attainment of ideal CVH and improvement in the CVH profile throughout life were associated with low baPWV or cfPWV at follow-up.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal association between cardiovascular health and arterial stiffness in the Chinese adult population

et al. 2021

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Objective Arterial stiffness may be an intermediary biological pathway involved in the association between cardiovascular health (CVH) and cardiovascular disease. We aimed to evaluate the effect of CVH on progression of brachial–ankle pulse wave velocity (baPWV) over approximately 4 years. Methods We included 1315 cardiovascular disease-free adults (49±12 years) who had two checkups from 2010 to 2019. CVH metrics (current smoking, body mass index, total cholesterol, blood pressure, and fasting plasma glucose) were assessed at baseline, and the number of ideal CVH metrics and CVH score were calculated. Additionally, baPWV was examined at baseline and follow-up. Results Median baPWV increased from 1340 cm/s to 1400 cm/s, with an average annual change in baPWV of 15 cm/s. More ideal CVH metrics and a higher CVH score were associated with lower baseline and follow-up baPWV, and the annual change in baPWV, even after adjustment for confounding variables. Associations between CVH parameters and baseline and follow-up baPWV remained robust in different sex and age subgroups, but they were only able to predict the annual change in baPWV in men and individuals older than 50 years. Conclusions Our findings highlight the benefit of a better baseline CVH profile for progression of arterial stiffness.

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Association between ideal cardiovascular health score trajectories and arterial stiffness: the Kailuan Study

Cited by 21 publications

References 35 publications

Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations

Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations

Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study

Longitudinal association between cardiovascular health and arterial stiffness in the Chinese adult population

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