Association between<i>miRNA-146a</i>and Polymorphisms of its Target Gene,<i>IRAK1</i>, Regarding Susceptibility to and Clinical Features of Systemic Lupus Erythematous and Multiple Sclerosis

Labib, Dina; Shaker, Olfat G.; Refai, Rasha M. El; Ghoniem, Shada; Elmazny, Alaa

doi:10.1093/labmed/lmy033

Cited by 24 publications

(24 citation statements)

References 31 publications

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“…The EDSS score ranges from 0-10 in 0.5-unit increments, with a higher score representing a higher level of disability (23). A value of 6 is a cut-off value, with scores ≥6 meaning a patient who is immobile and requires a walking aid to walk ~100 m with or without rest (15,23). Patients with concurrent autoimmune or inflammatory diseases or malignancies, patients suspected to be drug or alcohol addicts, or pregnant patients were excluded from the present study.…”

Section: Methodsmentioning

confidence: 99%

“…The age of onset level was set at 30 years as MS primarily manifests in young adults aged 20-40 years (24) and this age is similar to the mean age of onset in the present study. Patients were also divided into two groups based on the EDSS values; the threshold of severe MS was set as an EDSS score of 6 in accordance with a previous study (15). Finally, patients with MS were divided according to the subtype, RRMS and SPMS (25).…”

Section: Methodsmentioning

confidence: 99%

“…Single nucleotide polymorphisms (SNPs) are single nucleotide variations that occur at a unique site in the DNA (14). These changes in the DNA sequence can affect the susceptibility to different diseases, including autoimmune diseases (15). SNPs in miR-155 rs767649 and miR-146a rs57095329 are associated with the development of immune-system dysfunctions (16,17).…”

Section: Introductionmentioning

confidence: 99%

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Relationship between miR‑155 and miR‑146a polymorphisms and susceptibility to multiple sclerosis in an Egyptian cohort

et al. 2020

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Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system. It was previously demonstrated that miR-155 and miR-146a served a vital role in the pathophysiology of MS, and single nucleotide polymorphisms in miR-155 and miR-146a were found to be associated with the susceptibility to different autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and type I diabetes. The aim of the present study was to analyze the association between susceptibility to MS and two genetic polymorphisms (miR-155 rs767649 A>T and miR-146a rs57095329 A>G) in a cohort of Egyptian patients. The presence of the two polymorphisms were analyzed in 114 patients with MS and 152 healthy controls using quantitative PCR. The present study demonstrated for the first time that: The TT genotype and T allele in miR-155 (rs767649 A>T) polymorphism were associated with an increased risk of MS; the miR-146a (rs57095329 A>G) mutated G allele conferred protection against the development of MS in all genetic models; miR-155 rs767649 A>T was a risk associated polymorphism of MS in females, but not in males; and miR-155 rs767649 AT/TT and miR-146a rs57095329 GG genotypes showed significantly higher distributions among patients with higher Expanded Disability Status Scale scores and secondary progressive MS subgroups. Therefore, miR-155 rs767649 polymorphism may confer susceptibility to MS, whereas miR-146a rs57095329 may be protective against MS in an Egyptian cohort.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationship between miR‑155 and miR‑146a polymorphisms and susceptibility to multiple sclerosis in an Egyptian cohort

et al. 2020

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“…A great number of miR-polymorphisms have been associated with many diseases, including CNS-related disorders [102]. As an example, association between miR-146a and polymorphisms of its target gene, interleukin receptor associated kinase 1 (IRAK1), contributed to the susceptibility of MS patients [103]. Notably, Zhang et al [104] reported that miR-146a promoted remyelination in CNS via IRAK1, and that miRIDIAN miR-146a mimic treatment (by Dharmacon) significantly decreased the level of the protein IRAK1 [104].…”

Section: Potential Role Of Mirna Polymorphisms In Drug Response and Ementioning

confidence: 99%

Precision Medicine in Neurodegenerative Diseases: Some Promising Tips Coming from the microRNAs’ World

Nuzziello

Ciaccia

Liguori

2019

Cells

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Novel insights in the development of a precision medicine approach for treating the neurodegenerative diseases (NDDs) are provided by emerging advances in the field of pharmacoepigenomics. In this context, microRNAs (miRNAs) have been extensively studied because of their implication in several disorders related to the central nervous system, as well as for their potential role as biomarkers of diagnosis, prognosis, and response to treatment. Recent studies in the field of neurodegeneration reported evidence that drug response and efficacy can be modulated by miRNA-mediated mechanisms. In fact, miRNAs seem to regulate the expression of pharmacology target genes, while approved (conventional and non-conventional) therapies can restore altered miRNAs observed in NDDs. The knowledge of miRNA pharmacoepigenomics may offers new clues to develop more effective treatments by providing novel insights into interindividual variability in drug disposition and response. Recently, the therapeutic potential of miRNAs is gaining increasing attention, and miRNA-based drugs (for cancer) have been under observation in clinical trials. However, the effective use of miRNAs as therapeutic target still needs to be investigated. Here, we report a brief review of representative studies in which miRNAs related to therapeutic effects have been investigated in NDDs, providing exciting potential prospects of miRNAs in pharmacoepigenomics and translational medicine.

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“…A genetic study on Egyptian population has studied SNPs rs2910164 (MIR146A) and rs3027898 (IRAK1) and its influence to suspect Systemic Lupus Erythematosus (SLE) and MS autoimmune diseases (Labib et al 2019). The study was applied on 80 SLE cases, 70 MS cases and 120 controls.…”

Section: Introductionmentioning

confidence: 99%

Multiple sclerosis: an associated single-nucleotide polymorphism study on Egyptian population

Hamid¹,

Ali

Saad

et al. 2020

Netw Model Anal Health Inform Bioinforma

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Multiple Sclerosis (MS) is an autoimmune disease that severely impacts the central nervous system. Thanks to the evolutionary genetic information studied and published, researches have started to study MS from a genetic perspective. This paper provides a study of six single-nucleotide polymorphisms (SNPs)-MIR137HG (rs1625579), GAS5 (rs2067079), MIR3142HG (rs57095329), MIR146A (rs2910164), MIR155HG (rs767649) and IRAK1 (rs3027898)-and demonstrates their association with MS. This study was applied over an Egyptian dataset of 38 MS patients and 35 controls. Hence, different models were applied, Dominant, Recessive and Genotypic models along with Fisher's Exact method, Basic case-control analysis and Logistic regression analysis. This paper shows that the SNPs rs1625579, rs57095329, rs767649 and rs3027898 are associated with MS (p value < 0.05) according to all tested models except for Recessive model, that has add-in the relevance of rs1625579, rs57095329, rs2910164 and rs767649 with MS disease.

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Association betweenmiRNA-146aand Polymorphisms of its Target Gene,IRAK1, Regarding Susceptibility to and Clinical Features of Systemic Lupus Erythematous and Multiple Sclerosis

Cited by 24 publications

References 31 publications

Relationship between miR‑155 and miR‑146a polymorphisms and susceptibility to multiple sclerosis in an Egyptian cohort

Relationship between miR‑155 and miR‑146a polymorphisms and susceptibility to multiple sclerosis in an Egyptian cohort

Precision Medicine in Neurodegenerative Diseases: Some Promising Tips Coming from the microRNAs’ World

Multiple sclerosis: an associated single-nucleotide polymorphism study on Egyptian population

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