Association between<i>IL‐4</i>tagging single nucleotide polymorphisms and the risk of lung cancer in China

Tan, Nan; Song, Jiangjiang; Yan, Mengdan; Wu, Jia‐Min; Sun, Yao; Xiong, Zichao; Ding, Yipeng

doi:10.1002/mgg3.585

Cited by 15 publications

(13 citation statements)

References 33 publications

(33 reference statements)

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“…Moreover, IL-4 polymorphisms have been found linked with the risk of lung cancer (Tan et al, 2019). TLR4 is considered an important innate and adaptive immune response molecule against TB.…”

Section: Discussionmentioning

confidence: 99%

An Integrative Network Approach to Identify Common Genes for the Therapeutics in Tuberculosis and Its Overlapping Non-Communicable Diseases

et al. 2022

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Tuberculosis (TB) is the leading cause of death from a single infectious agent. The estimated total global TB deaths in 2019 were 1.4 million. The decline in TB incidence rate is very slow, while the burden of noncommunicable diseases (NCDs) is exponentially increasing in low- and middle-income countries, where the prevention and treatment of TB disease remains a great burden, and there is enough empirical evidence (scientific evidence) to justify a greater research emphasis on the syndemic interaction between TB and NCDs. The current study was proposed to build a disease-gene network based on overlapping TB with NCDs (overlapping means genes involved in TB and other/s NCDs), such as Parkinson’s disease, cardiovascular disease, diabetes mellitus, rheumatoid arthritis, and lung cancer. We compared the TB-associated genes with genes of its overlapping NCDs to determine the gene-disease relationship. Next, we constructed the gene interaction network of disease-genes by integrating curated and experimentally validated interactions in humans and find the 13 highly clustered modules in the network, which contains a total of 86 hub genes that are commonly associated with TB and its overlapping NCDs, which are largely involved in the Inflammatory response, cellular response to cytokine stimulus, response to cytokine, cytokine-mediated signaling pathway, defense response, response to stress and immune system process. Moreover, the identified hub genes and their respective drugs were exploited to build a bipartite network that assists in deciphering the drug-target interaction, highlighting the influential roles of these drugs on apparently unrelated targets and pathways. Targeting these hub proteins by using drugs combination or drug repurposing approaches will improve the clinical conditions in comorbidity, enhance the potency of a few drugs, and give a synergistic effect with better outcomes. Thus, understanding the Mycobacterium tuberculosis (Mtb) infection and associated NCDs is a high priority to contain its short and long-term effects on human health. Our network-based analysis opens a new horizon for more personalized treatment, drug-repurposing opportunities, investigates new targets, multidrug treatment, and can uncover several side effects of unrelated drugs for TB and its overlapping NCDs.

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Section: Discussionmentioning

confidence: 99%

An Integrative Network Approach to Identify Common Genes for the Therapeutics in Tuberculosis and Its Overlapping Non-Communicable Diseases

et al. 2022

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“…Peripheral blood (5 mL) from each subject was collected in test tube containing ethylenediamine tetraacetic acid and all blood samples were stored in a refrigerator at −80°C . Then, we extracted DNA from the blood samples using the Gold‐Mag nanoparticles method (Gold Mag Co., Ltd, Xian, China) and measured the DNA concentration and purity with a NanoDrop 2000C (Thermo Scientific, Waltham, MA, USA) …”

Section: Methodsmentioning

confidence: 99%

“…Peripheral blood (5 mL) from each subject was collected in test tube containing ethylenediamine tetraacetic acid and all blood samples were stored in a refrigerator at −80 C. 14 Then, we extracted DNA from the blood samples using the Gold-Mag nanoparticles method (Gold Mag Co., Ltd, Xian, China) 15,16 and measured the DNA concentration and purity with a NanoDrop 2000C (Thermo Scientific, Waltham, MA, USA). 17 We selected SNPs of LOC105377871 and CASC16 with the minor allele frequencies > 5% in global population from the 1000 Genome Project (http://www.internationalgenome.org). Furthermore, the genotype distribution of SNPs in the control group was in accordance with Hardy-Weinberg equilibrium (HWE) (p > 0.05).…”

Section: Snp Selection and Genotypingmentioning

confidence: 99%

Association of polymorphisms in LOC105377871 and CASC16 with breast cancer in the northwest Chinese Han population

Sun

Chen

et al. 2020

The Journal of Gene Medicine

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Background Breast cancer represents the cancer with the highest incidence and mortality among women in the world, and its pathogenesis is complex. Single nucleotide polymorphisms (SNPs) are one of the factors that influence the risk of breast cancer. The present study aimed to investigate the effects of LOC105377871 and CASC16 polymorphisms on the risk of breast cancer in the northwest Chinese Han population. Methods We selected 503 breast cancer patients and 503 healthy controls for the present study. Genotyping was performed using the Agena MassARRAY system (Agenea Bioscience, San Diego, CA, USA) and we evaluated the association between SNPs (rs17530068 and rs4784227) and the risk of breast cancer in four genetic models. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results It was found that the rs17530068 increased the breast cancer risk in log‐additive model (p = 0.047, OR = 1.23, 95% CI = 1.00–1.50). After stratification, the “T” allele of rs4784227 increased the risk of lymph node metastasis in breast cancer patients (allele: p = 0.025, OR = 1.51, 95% CI = 1.05–2.17; codominant model: p = 0.008, OR = 1.99, 95% CI = 1.20–3.31; dominant model: p = 0.008, OR = 1.94, 95% CI = 1.19–3.16; log‐additive model: p = 0.023, OR = 1.52, 95% CI = 1.06–2.19). Conclusions The results of the present study show that, in the northwest Chinese Han population, SNP rs17530068 (LOC105377871) increases the risk of breast cancer and SNP rs4784227 (CASC16) promotes lymph node metastasis in breast cancer patients.

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“…But our result was different from Cozar et al [25]; they did not find that the polymorphism of IL-4 rs2243250 was also associated with the susceptibility of renal cell carcinoma. In addition, Pan et al [32] and Tan et al [37] have found that IL-4-590C/T variant was relevant with the increased risk of lung cancer and gastric cancer. The possible reasons for the different results of the above studies have been summarized as follows: (1) the genetic background of the population was different; (2) the sample volume of Asians we included in this meta-analysis was much larger than that of Caucasians; (3) the methods of genotyping were different in these included studies; (4) the different types of smoking-related cancers had different relationships with IL-4 rs2243250 polymorphism.…”

Section: Discussionmentioning

confidence: 99%

Effects of IL-4-590C/T (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects

Chen

Song

et al. 2019

BioMed Research International

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Background Several previous studies have assessed the relationship between IL-4-590C/T gene polymorphism and smoking-related cancer in recent years; however, the results remain controversial. Based on it, the study intends to clarify whether IL-4-590C/T variant increases the risk of smoking-related cancer through meta-analysis. Methods We searched PubMed, EMBASE, Web of Science, Cochrane Library database, China National Knowledge Infrastructure, and Wanfang data information service platform to collect qualified case-control studies in strict accordance with the inclusion and exclusion standards. The 95% confidence interval (95% CI) and its odds ratio (OR) were adopted to access the relation between IL-4-590C/T gene polymorphism and smoking-related cancer; sensitivity analysis and publication bias assessment were carried out after the studies' quality evaluation. Results 17 studies were included in total, with 5,061 patients and 6,346 control cases. A significant association between IL-4-590C/T variant and smoking-related cancer in total population was revealed in our meta-analysis results, and IL-4-590C/T variant might have a relatively protective effect on smoking-related cancer (CT vs. TT: P=0.026, OR = 0.900, 95% CI: 0.820–0.987). Subgroup analysis by ethnicity showed that the IL-4-590C/T polymorphism was associated with a decreased risk of smoking-related cancer in the Asian population (CT vs. TT: P=0.008, OR = 0.878, 95% CI: 0.798–0.967; CC + CT vs. TT: P=0.030, OR = 0.903, 95% CI: 0.824–0.990). Subgroup analysis based on types of cancer demonstrated the IL-4-590C/T variant achieved a lower risk in renal cell cancer (CC vs. TT: P=0.046, OR = 0.640, 95% CI: 0.412–0.993). Conclusion There is a conspicuous association between IL-4-590C/T polymorphism and decreased risk of smoking-related cancer, particularly in Asians. And IL-4-590C/T polymorphism may have a protective effect on renal cell cancer.

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Association betweenIL‐4tagging single nucleotide polymorphisms and the risk of lung cancer in China

Cited by 15 publications

References 33 publications

An Integrative Network Approach to Identify Common Genes for the Therapeutics in Tuberculosis and Its Overlapping Non-Communicable Diseases

An Integrative Network Approach to Identify Common Genes for the Therapeutics in Tuberculosis and Its Overlapping Non-Communicable Diseases

Association of polymorphisms in LOC105377871 and CASC16 with breast cancer in the northwest Chinese Han population

Effects of IL-4-590C/T (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects

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