2015
DOI: 10.1159/000381106
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Abstract: Background: Hypouricemia, conventionally defined as a serum uric acid level of ≤2 mg/dl, is considered a biochemical disorder with no clinical significance. However, individuals with renal hypouricemia have a high risk of urolithiasis and exercise-induced acute kidney injury, both of which are risk factors for reduced kidney function. Methods: To test the hypothesis that individuals with hypouricemia would be at a higher risk of reduced kidney function, we conducted a population-based cross-sectional study usi… Show more

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Cited by 60 publications
(82 citation statements)
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“…[6] However, our study showed that hypouricemia per se in a general population did not cause severe kidney dysfunction in a long period (Table 2). All the hypouricemic subjects who had a history of kidney diseases had good kidney function in this study (Table 4), which suggested that the kidney diseases associated with these hypouricemic individuals showed a reversible kidney function.…”
Section: Discussionmentioning
confidence: 79%
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“…[6] However, our study showed that hypouricemia per se in a general population did not cause severe kidney dysfunction in a long period (Table 2). All the hypouricemic subjects who had a history of kidney diseases had good kidney function in this study (Table 4), which suggested that the kidney diseases associated with these hypouricemic individuals showed a reversible kidney function.…”
Section: Discussionmentioning
confidence: 79%
“…[6] Why is the prevalence of hypouricemia in this study lower than the previous studies? [6, 7] In previous studies, the subjects had regular follow-ups in hospitals and the prevalence of hypouricemia in them would be higher than the general population. The subjects of this study were derived from the general population, because they had annual medical check-ups at the center by themselves.…”
Section: Discussionmentioning
confidence: 91%
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“…Furthermore, a recent large cross-sectional population-based study from Japan demonstrated that men with hypouricemia face a higher risk of reduced kidney function [30] .…”
Section: Discussionmentioning
confidence: 99%