Association between Helicobacter pylori infection and Alzheimer’s disease in Japan

Helicobacter pylori-related ApoE 4 polymorphism may be associated with dysphagic symptoms in older adults

“…Based on histological analysis for Hp-I documentation, a higher prevalence of Hp-I in AD and mild cognitive impairment patients in a Greek cohort has been found, 2-4 increased cerebrospinal fluid anti-Hp IgG antibody levels in AD patients may reflect the disease severity, and Hp eradication may positively influence AD manifestations at 2-and 5-year clinical end-points. 3,4 Consistent associations with the Greek data were shown in subsequent studies from France, USA, and China, supporting Hp-I role in AD pathobiology. 4 Moreover, our unpublished data showed an association between Hp-I and ApoE 4 polymorphism involved in the pathophysiology of AD and possibly glaucoma (defined as 'ocular' AD); our findings revealed increased ApoE in AD patients, particularly in Hp-positive than in Hp-negative patients (26.92 vs. 18.75, P < 0.05).…”

“…3,4 Consistent associations with the Greek data were shown in subsequent studies from France, USA, and China, supporting Hp-I role in AD pathobiology. 4 Moreover, our unpublished data showed an association between Hp-I and ApoE 4 polymorphism involved in the pathophysiology of AD and possibly glaucoma (defined as 'ocular' AD); our findings revealed increased ApoE in AD patients, particularly in Hp-positive than in Hp-negative patients (26.92 vs. 18.75, P < 0.05). Furthermore, some studies reported frequent Hp-I presence (57%) in patients with laryngopharyngeal reflux disease (LPRD), 5 and Hp eradication showed a higher rate of symptom improvement (90%); 5 LPRD is associated with swallowing complaints and dysphagia.…”

Rhamnolipids, Microbial Virulence Factors, in Alzheimer’s Disease

“…The surviving cells are able to expel strongly inflammatory components including LPSs [16]. The imputed role of pathogens in AD has been extensively reported for about over 200 different helical bacterial spirochete species [17], which may co-infect with other Gram-negative phylotypes [18][19][20][21][22][23][24][25][26][27][28][29].…”

Does Helicobacter pylori Infection Increase Incidence of Dementia? The Personnes Agées QUID Study

“…A recent interventional study also concluded that successful H. pylori eradication may slow cognitive decline in AD and decrease mortality risk, but another study of 582 Japanese subjects did not confirm a greater prevalence of H. pylori infection in individuals with AD than in controls. These negative results are debatable because age and sex, known to be AD risk factors, were not comparable between cases and controls …”

“…These negative results are debatable because age and sex, known to be AD risk factors, were not comparable between cases and controls. 13 The association between AD and H. pylori infection has never been studied prospectively. The main objective of this study was to determine whether chronic H. pylori infection could be a risk factor for developing dementia by studying a prospective cohort of elderly adults followed over a 20-year period.…”