Association between genetic variation in the gene for insulin-like growth factor-l and low birthweight

Vaessen, Norbert; Janssen, Joseph A M J L; Heutink, Peter; Hofman, Albert; Lamberts, Steven W. J.; Oostra, Ben A.; Pols, Huibert A. P.; Duijn, Cornelia M. van

doi:10.1016/s0140-6736(02)08067-4

Cited by 189 publications

(181 citation statements)

References 4 publications

Supporting

Mentioning

165

Contrasting

Unclassified

Order By: Relevance

“…Women with the IGF1-19/-19 genotype were 276g lighter at birth compared with others (P = 0.06 adjusted for gestational age and BRCA1 mutation status). In the 33 BRCA1 carriers the effect was similar: women with the IGF1-19/-19 genotype were 287g lighter after adjustment for gestational age, which is in line with the findings of others (Vaessen et al, 2002).…”

Section: Discussionsupporting

confidence: 89%

Absence of the common IGF1 19 CA-repeat allele is more common among BRCA1 mutation carriers than among non-carriers from BRCA1 families

et al. 2007

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 89%

Absence of the common IGF1 19 CA-repeat allele is more common among BRCA1 mutation carriers than among non-carriers from BRCA1 families

et al. 2007

View full text Add to dashboard Cite

“…In a previous report, the same polymorphism was associated with increased risk of type 2 diabetes, and myocardial infarction, diminished insulin-secreting capacity and reduced adult height [40]. Interestingly, reduced insulin secretion has rarely been found underlying the glucose tolerance associated with low birthweight [7].…”

Section: Discussionmentioning

confidence: 86%

“…It has been postulated that genetic factors may play a role in the relationship between birthweight and the adult onset chronic diseases [34][35][36][37][38][39][40][41]. What is unclear, however, is the extent to which genetic factors may impact both on birthweight and subsequent fat accrual in childhood, and the adult outcomes.…”

Section: Discussionmentioning

confidence: 99%

Adult BMI and fat distribution but not height amplify the effect of low birthweight on insulin resistance and increased blood pressure in 20-year-old South Africans

et al. 2005

View full text Add to dashboard Cite

Aims/hypothesis: We examined whether associations between low birthweight and adult chronic cardiometabolic disease were dependent upon birthweight alone, or on interactions with BMI, fat accumulation either generally or abdominally, or attained height in young South African adults. Methods: Blood pressure (BP), lipids, glucose tolerance, insulin sensitivity and secretion (homeostasis model) were measured in 20-year-olds (n=132) born at full term and with birthweights on or below the tenth centile (underweight for gestational age [UFA]) or between the 25th and 75th centiles for gestational age (appropriate weight for gestational age, [AFA]). Sex-specific median measurements of BMI, waist circumference, percentage body fat and height defined current anthropometric status, providing four groups for each measure: UFA-low or UFAhigh and AFA-low or AFA-high. Results: The UFA-high BMI group was more insulin-resistant than both low BMI groups (p<0.04), but not the AFA-high BMI group. In contrast, plasma triglycerides and systolic BP were higher in the UFA-high than in all other groups (all p<0.04). When characterised by body fatness, both high percentage (%) body fat groups had higher fasting [insulin] than low percentage (%) body fat groups (p<0.03), and higher [total cholesterol] and [LDL cholesterol] than the UFA-low percentage (%) body fat group (p<0.05). The UFA-high group had higher systolic and diastolic BP than all other groups (all at least p<0.03). A similar pattern was observed when groups were characterised by waist circumference; however, current height status had no effect. Conclusions/ interpretation: These data indicate that the "fetal origins" expression of the chronic disease phenotype is not dependent on birthweight alone, but on its interaction with subsequent fat accumulation, though not on attained height, in this cohort of young adults.

show abstract

“…However, many important prenatal risk factors that impact on offspring development in utero are influenced by maternal characteristics (3)(4)(5)(6)(7). Consider the example of smoking in pregnancy, which is associated with a number of adverse outcomes in offspring including reduced birth weight and increased antisocial behavior.…”

mentioning

confidence: 99%

Disentangling prenatal and inherited influences in humans with an experimental design

Rice

Harold

Boivin

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

124

120

View full text Add to dashboard Cite

Exposure to adversity in utero at a sensitive period of development can bring about physiological, structural, and metabolic changes in the fetus that affect later development and behavior. However, the link between prenatal environment and offspring outcomes could also arise and confound because of the relation between maternal and offspring genomes. As human studies cannot randomly assign offspring to prenatal conditions, it is difficult to test whether in utero events have true causal effects on offspring outcomes. We used an unusual approach to overcome this difficulty whereby pregnant mothers are either biologically unrelated or related to their child as a result of in vitro fertilization (IVF). In this sample, prenatal smoking reduces offspring birth weight in both unrelated and related offspring, consistent with effects arising through prenatal mechanisms independent of the relation between the maternal and offspring genomes. In contrast, the association between prenatal smoking and offspring antisocial behavior depended on inherited factors because association was only present in related mothers and offspring. The results demonstrate that this unusual prenatal cross-fostering design is feasible and informative for disentangling inherited and prenatal effects on human health and behavior. Disentangling these different effects is invaluable for pinpointing markers of prenatal adversity that have a causal effect on offspring outcomes. The origins of behavior and many common complex disorders may begin in early life, therefore this experimental design could pave the way for identifying prenatal factors that affect behavior in future generations.child ͉ psychopathology ͉ genetic ͉ antisocial behavior ͉ birth weight

show abstract

Association between genetic variation in the gene for insulin-like growth factor-l and low birthweight

Cited by 189 publications

References 4 publications

Absence of the common IGF1 19 CA-repeat allele is more common among BRCA1 mutation carriers than among non-carriers from BRCA1 families

Absence of the common IGF1 19 CA-repeat allele is more common among BRCA1 mutation carriers than among non-carriers from BRCA1 families

Adult BMI and fat distribution but not height amplify the effect of low birthweight on insulin resistance and increased blood pressure in 20-year-old South Africans

Disentangling prenatal and inherited influences in humans with an experimental design

Contact Info

Product

Resources

About