Association between Family History and Gastric Carcinoma among Young Adults

Kikuchi, Shogo; Nakajima, Toshifusa; Nishi, Tsunehiro; Kobayashi, Osamu; Konishi, Toshiro; Inaba, Yutaka; Wada, Osamu; Satou, Hiroshi; Ishibashi, Teruo; Ichikawa, Saori; Okamoto, Naoyuki; Hirata, Toru; Kubo, Takuji; Sato, Nobuhiro; Miki, Kazumasa; Myoga, Akio

doi:10.1111/j.1349-7006.1996.tb00226.x

Cited by 27 publications

(19 citation statements)

References 10 publications

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“…The increased risk was not altered after multivariate adjustment for known or suspected risk factors of the disease. This result is consistent with the previous results of case-control, [11][12][13][14][15] cross-sectional 16,22,23 and prospective studies. 9 Our study more clearly demonstrated that the effect of family history varies in relation to the age and gender of the study participants and the type of affected relatives.…”

Section: Family History and Stomach Cancersupporting

confidence: 93%

Family history and the risk of stomach cancer death in Japan: Differences by age and gender

Yatsuya

Toyoshima

Mizoue

et al. 2001

Intl Journal of Cancer

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Familial aggregation of stomach cancer has long been observed. The effect on disease risk of family history and its magnitude according to the type of affected relatives, however, is not well known. We conducted a prospective analysis using the JACC study (Japan Collaborative Cohort Study For Evaluation of Cancer Risk, sponsored by Monbusho) data. During the follow-up period, 662 stomach cancer deaths were documented. A positive history of stomach cancer in one or more first-degree relatives was associated with a significantly increased risk of death from the disease in both men (RR 1.60; 95% CI 1.11-2.31) and women (RR 2.47; 95% CI 1.50 -4.06). In the subanalysis stratified by age, the association between positive family history and stomach cancer was stronger in the age group from 40 -59 (RR 2.62; 95% CI 1.34 -5.11 for men and RR 5.88; 95% CI 2.70 -12.82 for women) than in the age group from 60 -79 (RR 1.31; 95% CI 0.84 -2.05 for men and RR 1.44; 95% CI 0.72-2.88 for women). In the age group from 40 -59, men with father's history and women with mother's and sister's history of the disease had a significantly increased risk (RR 3.14; 95% CI 1.51-6.55, RR 10.46; 95% CI 4.54 -24.12, RR 13.39; 95% CI 3.89 -46.12, respectively). When 2 or more family members were affected, the increment in the risk was prominent especially in women (RR 9.45; 95% CI 4.46 -20.05). These results suggest the existence of a certain subtype of stomach cancer that is inherited more often by women from one generation to the next in gender-influenced fashion. Any preventive strategy should take into account the degree of individual susceptibility.

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Section: Family History and Stomach Cancersupporting

confidence: 93%

Family history and the risk of stomach cancer death in Japan: Differences by age and gender

Yatsuya

Toyoshima

Mizoue

et al. 2001

Intl Journal of Cancer

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“…Some studies found that a family history of stomach cancer was a stronger risk factor for women, 8,12,22,25 although the evidence is not consistent. 16 In some, 7,16,24 but not all 4,9,14 studies, the risk was higher for subjects with an affected sibling rather than a parent.…”

mentioning

confidence: 95%

“…Most research has been conducted in eastern Asian, 4,[8][9][10]12,13,18,[21][22][23] North American or in northern European countries, 2,5-7,11,15 but scanty information is available from Mediterranean countries. 14,20,24 The familial predisposition to stomach cancer, however, may have different genetic and environmental correlates in different populations, including a different prevalence of various susceptibility genes, and the impact of various environmental factors.…”

Section: 14mentioning

confidence: 99%

Family history of cancer and stomach cancer risk

Foschi

Lucenteforte

Bosetti

et al. 2008

Intl Journal of Cancer

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A family history of stomach cancer in first-degree relatives increases the risk of stomach cancer, but uncertainties remain as concerns the variation of the risk according to age, sex and type of relative, as well as on the role of family history of other cancers. We investigated the issue using data from a multicentric case-control study conducted in Italy between 1997 and 2007 on 230 cases aged not more than 80 years, with histologically confirmed incident gastric cancer and 547 controls admitted to hospital for acute, non neoplastic conditions. Logistic regression models adjusted for the effect of sex, age, year of interview, education, body mass index (BMI), tobacco smoking and number of brothers and sisters were used to estimate the odds ratios (OR) of stomach cancer. Relative to subjects with no history, those with a family history of gastric cancer had an OR of 2.5 (95% confidence interval (CI) 1.5-4.2). No significant heterogeneity emerged according to sex or age of the proband or of the affected relative, or smoking habits, BMI and education of the proband. As suggested from previous studies the OR was higher when the affected relative was a sibling (OR = 5.1, 95% CI: 1.3-20.6) rather than a parent (OR = 2.2, 95% CI: 1.2-3.9), although the heterogeneity test was not significant. The risk of stomach cancer was not increased in subjects with a family history of cancer at any other site. The OR for all sites excluding stomach was 1.0 (95% CI: 0.7-1.4). ' 2008 Wiley-Liss, Inc.Key words: stomach neoplasms; familial risk; risk factorsThe risk of stomach cancer is increased in subjects with family history of the disease. 1 Most epidemiologic studies reported a risk of gastric cancer between 1.5 and 3.5 for subjects with relatives with stomach cancer. This may be partly due to the fact that relatives tend to be exposed to the same environmental risk factors, but also to inheritable (genetic) susceptibility.Some studies found that a family history of stomach cancer was a stronger risk factor for women, 8,12,22,25 although the evidence is not consistent. 16 In some, 7,16,24 but not all 4,9,14 studies, the risk was higher for subjects with an affected sibling rather than a parent. Furthermore, the epidemiologic evidence is not consistent on the variation of familial risk according to the age at onset of gastric cancer. 8,11,14,16,22 Only a few studies have investigated the association of family history of other cancers and risk of stomach cancer, and yielded contrasting results. 2,[5][6][7]10,14,15 Associations have been reported with a family history of cancers of the breast, 15 brain/central nervous system, 2,6 female genital, 2,6 esophagus, 2 thyroid 2 and colon. 2 A study from Sweden found significant associations with a family history of cancer of the endometrium, and urinary bladder in siblings and of male genital cancers other than prostate in fathers. 7 Other studies, however, found no association with family history of any cancer other than gastric cancer. 5,14 Most research has been conducted in easter...

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“…Gastric cancer results from a combination of environmental factors and accumulation of specific genetic alterations. In conventional gastric cancer (presenting >45 years old), environmental factors play a more important role, compared to early onset gastric cancer (EOGC, presenting at ≤45 years old) where it is postulated that genetic factors may be more important [20]. We have previously shown that molecular differences exist between conventional gastric cancer and EOGC [4][5][6][29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

IL-1B −31T>C promoter polymorphism is associated with gastric stump cancer but not with early onset or conventional gastric cancers

et al. 2008

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It has been reported that interleukin-1beta (IL-1B) genes play a crucial role in the genetic predisposition to gastric cancer although there is no information about their role in different subtypes of gastric cancer. We performed single nucleotide polymorphism analysis of IL-1B in 241 gastric cancers including early onset gastric cancers (EOGC), conventional gastric cancers, and gastric stump cancers (GSCs) as well as 100 control patients, using real-time polymerase chain reaction and sequence analysis. The C allele was present in 60% of EOGCs, 59% of conventional gastric cancers, and 90% of GSCs, compared to 62% in the control group. Interestingly, there was no difference between early onset and conventional gastric cancer with respect to the IL-1B −31T>C polymorphism distribution. A statistically significant difference in the presence of the C allele compared to the control group was found in patients with gastric stump cancer ( p= 0.008) with the T allele conferring protection against gastric stump cancer. In summary, we have shown that the IL-1B −31C allele promoter polymorphism is significantly associated with gastric stump cancer compared to the control group. Although several molecular differences have been identified between conventional gastric cancer and early onset gastric cancer, the IL-1B −31 allele distribution is similar between these two groups.

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Association between Family History and Gastric Carcinoma among Young Adults

Cited by 27 publications

References 10 publications

Family history and the risk of stomach cancer death in Japan: Differences by age and gender

Family history and the risk of stomach cancer death in Japan: Differences by age and gender

Family history of cancer and stomach cancer risk

IL-1B −31T>C promoter polymorphism is associated with gastric stump cancer but not with early onset or conventional gastric cancers

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