Association between ERCC5 gene polymorphisms and gastric cancer risk in a Chinese population

Abstract

ABSTRACT. We conducted a hospital-based case-control study to investigate the association between 3 common SNPs in the ERCC5 gene (rs1047768, rs751402, and rs17655) and the risk of developing gastric cancer. Between January 2013 and December 2014, samples were collected from 216 gastric cancer patients and 216 control subjects. ERCC5 rs1047768, rs751402, and rs17655 polymorphisms were genotyped by polymerase chain reaction combined with restriction fragment length polymorphism analysis. By conditional logistic regression analysis, the GG genotype of rs17655 was found to be associated with an elevated risk of gastric cancer in a codominant model, and the adjusted OR (95%CI) was 1.96 (1.10-3.50). Moreover, in a dominant model, the CG + GG genotype of rs17655 was correlated with an increased risk of gastric cancer compared to the CC genotype (OR = 1.48; 95%CI = 1.00-2.22). rs1047768 and rs751402 were not significantly correlated with an increased or decreased gastric cancer risk.

XPGgene polymorphisms and cancer susceptibility: evidence from 47 studies

“…The final meta-analysis included 47 articles. There were 22 articles with 12,833 cases and 151,86 controls for rs1047768 T>C [ 7 – 9 , 12 , 14 – 31 ], 14 studies with 11,327 cases and 12,684 controls for rs2296147 T>C [ 9 – 11 , 13 , 18 , 24 , 26 – 28 , 32 – 37 ], 11 studies with 5,898 cases and 7,448 controls for rs2227869 G>C [ 8 , 9 , 14 , 17 , 18 , 20 , 22 , 25 , 38 – 40 ], 17 studies with 9,826 cases and 10,552 controls for rs2094258 C>T [ 10 , 11 , 18 , 24 , 26 – 28 , 34 – 37 , 41 – 46 ], 21 studies with 10,369 cases and 11,207 controls for rs751402 C>T [ 10 , 13 , 24 , 26 – 29 , 31 , 32 , 36 , 37 , 42 – 45 , 47 – 52 ], and 14 studies with 10,873 cases and 12,535 controls for rs873601 G>A [ 9 – 11 , 18 , 24 , 26 – 28 , 32 , 34 , 36 , 52 – 54 ]. A flow chart summarizing the process of relevant study identification is shown in Figure 1 , and the study characteristics are shown in Table 1 .…”

Association of XPG gene rs751402 polymorphism with gastric cancer risk: a meta-analysis in the Chinese population

“…However, the results from basic medical research need to be confirmed by population studies. In recent years, some articles (13)(14)(15)(16)(17)(18)(19)(20)(21) have investigated the correlation between rs751402 mutation and GC risk among populations, but the results have been controversial. A possible explanation is that most of these studies have had small sample sizes.…”

“…Since transcription of XPG is correlated with altered transcription domain-associated repair capacity (12), this promoter mutation seems to be associated with cancer. Studies have estimated the association between XPG genetic polymorphism (rs751402 C>T) and risk of GC (13)(14)(15)(16)(17)(18)(19)(20)(21). However, their conclusions remain conflicting.…”