Association between Duration of Exercise (MET Hours per Week) and the Risk of Decreased eGFR: A Cross-Sectional Study Based on a Large Chinese Population

Abstract

Background. Physical activity is effective in preventing chronic diseases. However, the impact of different durations of exercise on human health is unknown, especially among people with diabetes or prediabetes. Objective. To explore the relationship between high MET hours per week and the change in glomerular filtration rate (eGFR) in the total population and different subgroups. Methods. A total of 43767 individuals from eight provinces, in China, were recruited. Logistic analysis was used to investigate the association. Participants were divided into 3 groups based on MET hours per week. The primary outcome was an eGFR≤90 mL/min/1.73 m2. Results. The average eGFR was 100.10 (92.43-106.43) mL/min/1.732. Logistic regression analysis revealed that more than 7.5 MET hours per week (equivalent to more than 150 minutes of moderate-intensity of exercise) was associated with the higher risk of the decreased eGFR even after adjusting for confounding factors (7.5 to <21: OR=1.18, 95% CI [1.09, 1.29]; ≥21: OR=1.12, 95% CI [1.05, 1.19], p for trend: 0.0047). After adjusting for confounding factors, in stratified analyses, there still existed a significant relationship among participants aged from 55 to less than 65 years, but not among participants younger than 55 or older than 65 years. Similarly, there existed a positive association between high MET hours per week and the decreased eGFR in participants without diabetes and prediabetes, but not in participants with diabetes or prediabetes, and the interactions of age and diabetic states were found. However, there was no significant difference in women or men. Conclusions. More than 7.5 MET hours per week (equivalent to more than 150 minutes per week or 60 minutes per day of moderate-intensity exercise) was associated with decreased eGFR among participants aged from 55 to less than 65 years and participants without diabetes and prediabetes, but not among participants aged younger than 55 years and older than 65 years and participants with diabetes or prediabetes. The importance of planning individualized physical activities is highlighted.

Prediction of incident chronic kidney disease in a population with normal renal function and normo-proteinuria

“…Our finding showed that the high activity group (≥3000 METs-min/week) was positively associated with the risk of incident CKD. A similar result was reported in a cross-sectional study by Wang et al [ 40 ] indicating that the high-intensity exercise group was associated with decreased eGFR (≤90 mL/min/1.73 m 2 ). These results imply the importance of the proper intensity and time of exercise for high-risk subjects with incident CKD, and the possible differential association between physical activity and CKD needs to be confirmed in future studies.…”

The Effectiveness of Local Dance Training of the Northeastern Thailand (Champa Sri) to Increase Glomerular Filtration Rate (GFR) in Elderly Women in Mahasarakham Province, Thailand

“…The eGFR's result had a higher value (lower risk) than control group. It was consistent with eGFR's result by using duration of exercise training in large Chinese population 4,9 and aerobic exercise training in non-dialysis chronic kidney disease 5 . It helps improving the vascular function and maintain the function of the arteries.…”

Association of the Reproductive Period with Decreased Estimated Glomerular Filtration Rate in Menopausal Women: A Study from the Shanghai Suburban Adult Cohort and Biobank (2016–2020)

“…A meta-analysis found that physical activity can help improve the eGFR (by 5.22 mL/min/1.73 m 2 ) with short-term exercise (<3 months), but not with 3–6 months of exercise or 6–12 months of exercise in CKD patients, indicating the diverse effects of different modes and amounts of exercise on eGFR [ 50 ]. In contrast, a cross-sectional study based on the Chinese population reported that >7.5 MET-hours per week was significantly associated with the risk of decreased eGFR in participants without a history of kidney diseases, aged from 55–65 years, but not in participants younger than 55 or older than 65 years [ 51 ]. It is hypothesized that in certain age groups of the Chinese population, light-to-moderate physical exercise increases the risk of renal dysfunction.…”