Association between digital breast tomosynthesis and molecular subtypes of breast cancer

Cai, Sanjun; Yao, Miaomiao; Cai, Donglu; Yan, Jianxiang; Huang, Meiling; Yan, Lisheng; Huang, Huirong

doi:10.3892/ol.2019.9918

Cited by 5 publications

(5 citation statements)

References 29 publications

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“…Since it is a relatively recent technique, speci c features of breast cancers on DBT have indeed been scarcely described. To the best of our knowledge, only one study evaluated the appearance of breast cancers on DBT according to their histology and molecular pro le [5]. In line with our results, they showed that presence of calci cations within the tumors on DBT was more frequent in HER-2 + than in other types of breast cancers.…”

Section: Discussionsupporting

confidence: 76%

“…Although correlation between histology and imaging has been widely described previously on digital mammography (DM), speci c features of breast cancers on digital breast tomosynthesis (DBT) have rarely been reported. Only one recent study suggested that morphological features on DBT could be associated with molecular characteristics [5], but very little data are available to support this assertion. Breast cancer features on 2D synthetic mammography (SM) have not yet been reported, although it has been reported that the additional cancers detected with the adjunct of DBT in the screening setting would preferentially be less aggressive tumors with luminal molecular pro les [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Conspicuity and imaging features of breast cancers on digital breast tomosynthesis according to molecular profile

Manse

Boisserie-Lacroix

Brouste

et al. 2021

Preprint

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Objective To describe BI-RADS features and evaluate conspicuity of breast cancer on digital breast tomosynthesis (DBT) according to their molecular profile. Materials and method Institutional review board was obtained for this retrospective study. Consecutive patients with histologically proven breast cancers who underwent digital breast tomosynthesis (DBT) with 2D synthetic mammography (SM) and digital mammography (DM) at the time of diagnosis were included. Morphological features and conspicuity of cancers on DM, SM and DBT were evaluated in consensus by two breast radiologists. Imaging features were compared across molecular subtypes (luminal, triple negative (TN) and HER2+) using Fisher’s exact test and between DBT and SM and DM using McNemar’s test. Conspicuity was compared between DBT and SM and DM using Wilcoxon matched pairs test and between each molecular subtype using the Wilcoxon test. Results One hundred and eleven consecutive patients were included. On DBT, TN cancers more frequently presented as masses with microlobulated margins (P = 0.04) while HER2 + cancers were more often associated with microcalcifications (P = 0.02). Greater conspicuity on DBT in comparison to DM was observed for cancers with low Ki67 (P = .015), less aggressive tumours (P = .005), positive ER (P = 0.005), positive PR (P = .005) or negative HER2 (P = .024), and for luminal molecular profiles (P = 0.012) while no difference was observed between the two techniques for TN (P = .73) and HER+ (P = .79) tumours. Conclusion DBT reveals specific features of breast cancers according to their molecular characteristics. In comparison with DM, DBT improves conspicuity of luminal subtype cancers and tumours demonstrating less aggressive features on pathology.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Conspicuity and imaging features of breast cancers on digital breast tomosynthesis according to molecular profile

Manse

Boisserie-Lacroix

Brouste

et al. 2021

Preprint

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“…The findings show that DBT can demonstrate the lesion margins, microcalcifications, and lymph nodes more accurately. Besides, the HER2 overexpression subtype was associated with a larger tumor size and more microcalcifications compared to the lumi- nal B subtype on DBT (21). Conversely, a recent prospective population-based study demonstrated no significant difference between DM and DBT in terms of histological subtypes (22).…”

Section: Discussionmentioning

confidence: 87%

Is Digital Breast Tomosynthesis Superior to Digital Mammography? A Preclinical Evaluation of Tumor Histopathological Markers Using Digital Breast Tomosynthesis

et al. 2021

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Background: Digital mammography (DM) and digital breast tomosynthesis (DBT) are important radiological modalities, which increase the survival of breast cancer patients. Breast cancer is a morphologically heterogeneous disease with various histopathological parameters and multiple receptors in its biological profile. Objectives: This study aimed to analyze the morphological features of invasive breast cancer on DM and DBT, to investigate the contribution of DBT to DM, to examine the association of DBT findings with pathological molecular subtypes, Bloom-Richardson grade, and Ki-67 index, and to determine the effect of breast parenchyma density on the relationship between DBT findings and hormone receptors. Patients and Methods: A total of 36 patients with malignant lesions were evaluated in this study. According to the American College of Radiology (ACR) classification, the lesion features were divided into subgroups based on DM and DBT, and the findings were compared. The relationships between DBT findings and the hormone receptor status, molecular classification, and Bloom-Richardson grade were also investigated, and the effect of density on these relationships was assessed. Results: The mean age of the patients (n = 36) was 53 years. Based on the comparison of DM and DBT findings, spiculated margins, mass density, architectural distortion, and microcalcifications were significantly more frequent in DBT. Lesions with indistinct margins on DM were observed as mass lesions with spiculated margins on DBT (P < 0.001). Regarding the relationship between DBT findings and hormone receptor status and Ki-67 proliferation index, in PR-positive patients, an irregular tumor shape was more common (89.7%). In PR-negative patients, skin changes and nipple retraction were more frequently seen (P = 0.03 for skin changes, and P = 0.049 for nipple retraction). Regarding the association between Bloom-Richardson grade and DBT findings, tumors with a higher grade were more likely to be associated with a high tumor density (P = 0.032). Also, considering the relationship between molecular classification and DBT findings, skin changes and nipple retraction were significantly more frequent in triple-negative masses compared to other subtypes (P = 0.011 for skin changes and P = 0.016 for nipple retraction). Conclusions: DBT is superior to DM, as it reveals the lesion margins, density, and architectural distortion more accurately. The majority of PR-positive tumors were irregular, while most PR-negative cases were round. The mass density also increased as the tumor grade increased. Skin change and nipple retraction were frequently seen in triple-negative tumors compared to other subtypes. Therefore, DBT is a promising diagnostic tool for showing molecular subtypes in dense breasts.

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“…As was demonstrated by prospective European studies, the addition of DBT led to an increase in cancer detection rate (CDR) from 27% to 91% [69,70]. Moreover, assistant diagnostic markers such as DBT-determined lymph node size, as well as calcification score, could be used also to determine BC molecular subtypes [71]. A comparison of TOMosynthesis with digital MammographY in the UK NHS Breast Screening Programme (TOMMY) trial showed the superior value of DBT for women with a breast density of 50% or more with sensitivity 93% and specificity 70% compared to 2D mammography (86% sensitivity and 57% specificity) [72].…”

Section: Screening and Diagnosticsmentioning

confidence: 99%

Breast Cancer in Young Women: Status Quo and Advanced Disease Management by a Predictive, Preventive, and Personalized Approach

Kúdela

Samec

Kubatka

et al. 2019

Cancers

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Why does healthcare of breast cancer (BC) patients, especially in a young population, matter and why are innovative strategies by predictive, preventive, and personalized medicine (PPPM) strongly recommended to replace current reactive medical approach in BC management? Permanent increase in annual numbers of new BC cases with particularly quick growth of premenopausal BC patients, an absence of clearly described risk factors for those patients, as well as established screening tools and programs represent important reasons to focus on BC in young women. Moreover, "young" BC cases are frequently "asymptomatic", difficult to diagnose, and to treat effectively on time. The objective of this article is to update the knowledge on BC in young females, its unique molecular signature, newest concepts in diagnostics and therapy, and to highlight the concepts of predictive, preventive, and personalized medicine with a well-acknowledged potential to advance the overall disease management.

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Association between digital breast tomosynthesis and molecular subtypes of breast cancer

Cited by 5 publications

References 29 publications

Conspicuity and imaging features of breast cancers on digital breast tomosynthesis according to molecular profile

Conspicuity and imaging features of breast cancers on digital breast tomosynthesis according to molecular profile

Is Digital Breast Tomosynthesis Superior to Digital Mammography? A Preclinical Evaluation of Tumor Histopathological Markers Using Digital Breast Tomosynthesis

Breast Cancer in Young Women: Status Quo and Advanced Disease Management by a Predictive, Preventive, and Personalized Approach

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