Association between Dietary Intake of One-Carbon Metabolism Nutrients in the Year before Pregnancy and Birth Anthropometry

Abstract

Few studies have evaluated the role of methylation-pathway nutrients involved in fetal growth (B vitamins, choline, betaine, and methionine). These one-carbon metabolism (OCM) nutrients are essential for DNA methylation in the periconception period. We aimed to characterize dietary patterns of 1638 women from the EDEN mother-child cohort in the year before pregnancy according to the contribution of OCM nutrients and to study the association of such patterns with anthropometric measurements at birth. Dietary intake before pregnancy was assessed by using a semi-quantitative food frequency questionnaire. We used the reduced-rank regression (RRR) method to identify dietary patterns using OCM nutrients as intermediate variables. We ran linear regressions models to study the association between dietary patterns scores and birth weight, length, head circumference, gestational age, and sex-specific z-scores, adjusting for maternal characteristics and vitamin supplementation before and during pregnancy. Three patterns, “varied and balanced”, “vegetarian tendency”, and “bread and starchy food” were identified, explaining 58% of the variability in OCM nutrient intake. Higher scores on the “varied and balanced” pattern tended to be associated with higher birth length and weight. In mainly well-nourished young French women, we did not find evidence that variability in OCM nutrient intake has major effects on fetal growth.

The association of dietary choline and betaine and anthropometric measurements among Iranian children: a cross-sectional study

“…Previous work in adults has shown that supplementation of dietary choline and betaine led to decreased visceral fat accumulation, waist circumference, and body weight which suggests they may contribute to the development of chronic disease [32,33]. However, limited studies exist in children investigating their role, and findings in adults remain inconsistent [32,[34][35][36]. Children get ready to enter the school environment at six years of age and experience more independence to self-select and manage their own food menu choices [37].…”

Association between dietary patterns reflecting one-carbon metabolism nutrients intake before pregnancy and placental DNA methylation

“…The diet of women during the year before pregnancy was assessed retrospectively at inclusion (before 28 weeks' gestation; 15 weeks on average) by using a validated food-frequency questionnaire (13). A food composition database was not available to estimate the direct intake of some nutrients of interest (methionine, choline and betaine), so we used different sources to establish a food composition database and calculated individual nutrient intake following a methodology that we previously described (11). Three dietary patterns -"varied and balanced", "vegetarian tendency", and "bread and starchy food"were identified using the reduced rank regression method to characterize OCM micronutrient intake (folates, choline, betaine, methionine, vitamins B2, B6, B12) in the year before pregnancy (14).…”

“…The "vegetarian tendency" pattern was characterized by high coefficients for vitamin B6, B9 and betaine to the detriment of other nutrients such as vitamin B12, choline, and methionine. The "bread and starchy food" pattern was mainly characterized by a high coefficient for betaine and negative coefficients for vitamins B2, B6, and B9 (11). The main characteristics of the patterns are presented in Table 1.…”

“…The main characteristics of the patterns are presented in Table 1. Information on dietary supplementation in the 3 months before and during pregnancy was also collected by maternal self-completed questionnaires as consumption of mixed multivitamins/minerals or use of single micronutrients, among which we had information for vitamins B2, B6 and B9 (folic acid) as another source of OCM nutrient intake (11). This variable was defined in four categories: no supplementation, supplementation only before pregnancy, supplementation only during pregnancy, and supplementation before and during pregnancy.…”

Analisis Faktor Determinan Status Gizi Ibu Hamil Di Mombykids Jombang

“…Usia reproduktif yaitu 20-35 tahun berhubungan dengan kemampuan tubuh untuk menyerap nutrisi dalam tubuh secara optimal sehingga ibu hamil dapat memiliki status gizi yang baik dan bermanfaat bagi bayi untuk pemenuhan nutrisi (Ogundipe et al, 2012). Status gizi ibu hamil juga dikaitkan dengan pengetahuan ibu, pengetahuan terkait nutrisi ibu hamil menjadi salah satu faktor yang berpengaruh terhadap status gizi ibu hamil, salah satu cara yang dapat dilakukan untuk meningkatkan pengetahuan dengan mengikuti kegiatan penyuluhan kesehatan ibu hamil sehingga ibu tahu terkait nutrisi yang baik sebelum dan sesudah kehamilan (Lecorguillé et al, 2020).Berdasarkan uraian latar belakang diatas peneliti tertarik untuk penelitian tentang analisis faktor determinan status gizi ibu hamil di momby kids Jombang.…”