Association between diabetes mellitus and health-related quality of life among patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)

Chen, Li; Wang, Jinwei; Huang, Xiaoyan; Wang, Fang; Liang, Wei; He, Yan; Liao, Yumei; Zhang, Luxia; Zhao, Ming‐Hui; Xiong, Zuying

doi:10.1186/s12955-020-01519-5

Cited by 5 publications

(6 citation statements)

References 28 publications

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“…Moreover, a declining physical component score during the study period was more pronounced in those with more advanced CKD. Similarly, the presence of DM was significantly associated with lower HRQoL, particularly with lower physical function, in CKD patients [29]. Furthermore, in previous studies, poor physical quality of life was associated with a higher risk of mortality in patients with CKD or comorbid DM and CKD [26,30,31].…”

Section: Discussionmentioning

confidence: 74%

Chronic Kidney Disease on Health-Related Quality of Life in Patients with Diabetes Mellitus: A National Representative Study

Hong

Kim

Zhao

et al. 2021

JCM

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Importance: With an increasing prevalence of diabetes mellitus (DM) and comorbid chronic kidney disease (CKD), health-related quality of life (HRQoL) in patients with DM and CKD needs to be better understood. Objective: To investigate the association between the severity of CKD on HRQoL in DM patients. Design: A cross-sectional study of a nationally representative population-based survey, the Korea National Health and Nutrition Examination Survey (KNHANES). Setting: Data collected between 2007 and 2018 from the KNHANES. Participants: Adult participants with DM who completed the self-administered European Quality of Life Questionnaire Five Dimension (EQ-5D) questionnaire (n = 7243). Exposures: CKD stages defined by the Kidney Disease Improving Global System (KDIGO) staging system. Main Outcomes and Measures: We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of the presence of having problems in the 5 dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression) of EQ-5D by CKD stage after adjusting for socio-demographic parameters and comorbid conditions. In addition, the EQ-5D index, reflecting the overall health status, was compared across CKD stages. Results: Among 7243 participants (mean (standard error) age 58.2 (0.2) 56.9% male), 24.0% (n = 1768) had CKD and 8.6% (n = 775) had stage 3–5 CKD. Pain/discomfort was the most common problem (30.5%) among patients with DM. Participants with more advanced CKD were more likely to experience problems in all dimensions of EQ-5D except the anxiety/depression dimension. In particular, compared to those without CKD, the adjusted ORs (95% CI) for any problem in the usual activities dimension was 1.65 (1.30, 2.10) in CKD stage 3 and 4.23 (2.07, 8.67) in CKD stage 4–5. Moreover, participants with stage 3 (−0.016 (−0.029, −0.003)) and stage 4–5 CKD (−0.088 (−0.129, −0.048)) had significantly lower EQ-5D index than those without CKD. However, compared with no CKD, CKD stage 1–2 was not significantly associated with having any problem in any dimensions. Conclusions and Relevance: In this nationally representative study, patients with DM had a high prevalence of self-reported poor HRQoL and the prevalence increased with more advanced stages of CKD. Therefore, assessment of HRQoL and interventions are necessary at early stages of CKD in DM patients.

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Section: Discussionmentioning

confidence: 74%

Chronic Kidney Disease on Health-Related Quality of Life in Patients with Diabetes Mellitus: A National Representative Study

Hong

Kim

Zhao

et al. 2021

JCM

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“…Inconsistent with these results,(Chen et al, 2020) (11) recorded that DM was negatively correlated with HRQOL scores in both categories, but the magnitude and dimensions and of correlation were…”

Section: Ethical Considerationsmentioning

confidence: 89%

“…Evaluating health-related quality of life and associated variables in patients with Diabetic Nephropathy and DM is critical for guiding health education and suitable personalized treatment. (11,12) At the level of disease prevention, increasing public awareness about diabetes and its associated risk factors as obesity and lack of exercise is essential and can support current institutional efforts. This can be achieved through collaborative work from all stakeholders such as the ministry of health (MOH) and universities in several ways such as including the publication of small Arabic booklets in plain language, Discussions, lectures, etc (13,14) Finally, to combat the increasing prevalence of diabetes, there is now an urgent need for a long-term national plan focusing on prevention, education, and a multidisciplinary approach.…”

Section: The United States National Kidneymentioning

confidence: 99%

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Association Between Diabetic Nephropathy Grade and Quality of Life among Type II Diabetic Patients

Othman

Elsherbini

Riad

2021

Tanta Scientific Nursing Journal

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Introduction: One of the most profound long-standing consequences of diabetes mellitus is diabetic nephropathy. In many countries, diabetes is proved to be the most frequent single cause of end-stage renal disease. Aim of the work: analyze the association between diabetic nephropathy grade and quality of life among type II diabetic patients. Material and methods: Quantitative descriptive study design applied on a purposive sample of 41 individuals with type II diabetes attended to the medical outpatient clinic in Menoufia University Hospital. Tools: Tool I-A structured interviewing questionnaire. Tool II-Assessment of the kidney function. Tool III-Kidney Disease Quality of Life. Results: serum creatinine and blood urea nitrogen were increased, also the estimated glomerular filtration rate (eGFR) was decreased in individuals with type II diabetes as disease duration increase. The prevalence of diabetic nephropathy in the current work was high representing 56.1%. In addition increasing body mass index more than 25. Diabetic nephropathy was associated with all five HRQOL dimensions as patients in stage 3-kidney disease had lower scores than patients in stages 1 and 2. Conclusion: The present data confirm that the most striking risk factors for diabetic nephropathy in the type II diabetes are BMI ≥ 25, diabetes duration, hypertension, age ≥ 50 years, and family history. Recommendation: The current study recommended that urinalysis should be performed regularly as part of a screening program which is a preventive intervention to preserve the kidneys in diabetic patients and will detect individuals with nephropathy early.

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“…A study of Japanese patients with chronic kidney disease (CKD) reported a gradual decrease in quality-adjustment weight with the progression of the CKD, as measured by the EQ-5D [24]. A cross-sectional study has reported both diabetes and albuminuria to be negatively associated with PCS and MCS scores in patients with CKD [25]. In addition, a longitudinal study of men with diabetes and comorbid DN found that proteinuria at enrollment was negatively associated with PCS and MCS on the kidney disease QoL measure at 4-month follow-up [26].…”

Section: Discussionmentioning

confidence: 99%

Effect of Low-Density Lipoprotein Apheresis on Quality of Life in Patients with Diabetes, Proteinuria, and Hypercholesterolemia

Hara¹,

Wada²,

Muso³

et al. 2022

Blood Purif

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Introduction: Treating diabetic nephropathy with low-density lipoprotein (LDL) apheresis reduces proteinuria and improves prognosis. However, its impact on patients’ quality of life (QoL) is unclear. This study evaluated the effect of LDL apheresis on QoL in patients with diabetes, proteinuria, and hypercholesterolemia. Methods: In this nationwide multicenter prospective study, we enrolled 40 patients with diabetes. Inclusion criteria were proteinuria (defined as an albumin/creatinine ratio ≥3 g/g), serum creatinine levels <2 mg/dL, and serum LDL ≥120 mg/dL despite drug treatment. LDL apheresis was performed 6–12 times within 12 weeks. The 36-item Short Form Health Survey (SF-36) was used to analyze QoL. Results: The study enrolled 35 patients (27 men and 8 women; mean age 58.9 ± 11.9 years). A comparison of baseline SF-36 values with those at the end of the course of apheresis found an improvement in the mean physical component summary (37.9 ± 11.4 vs. 40.6 ± 10.5, p = 0.051) and a significant increase in the mean mental component summary (MCS) (49.4 ± 8.4 vs. 52.5 ± 10.9, p = 0.026). A multivariable linear regression analysis revealed a history of coronary heart disease negatively correlated with the MCS increase at the end of the course of apheresis (β coefficient −6.935, 95% confidence interval, 13.313 to−0.556, p = 0.034). Conclusion: Our results suggest that LDL apheresis may improve the mental and physical QoL in patients with diabetes, proteinuria, and hypercholesterolemia.

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Association between diabetes mellitus and health-related quality of life among patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)

Cited by 5 publications

References 28 publications

Chronic Kidney Disease on Health-Related Quality of Life in Patients with Diabetes Mellitus: A National Representative Study

Chronic Kidney Disease on Health-Related Quality of Life in Patients with Diabetes Mellitus: A National Representative Study

Association Between Diabetic Nephropathy Grade and Quality of Life among Type II Diabetic Patients

Effect of Low-Density Lipoprotein Apheresis on Quality of Life in Patients with Diabetes, Proteinuria, and Hypercholesterolemia

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