Association between Corneal Biomechanical Properties with Ocular Response Analyzer and Also CorvisST Tonometry, and Glaucomatous Visual Field Severity

Abstract

PurposeTo investigate the association between corneal biomechanical properties measured with the Ocular Response Analyzer (ORA) and also CorvisST (CST) tonometry, and glaucomatous visual field (VF) severity.MethodsOne hundred forty-six eyes of 91 patients with primary open-angle glaucoma who performed Humphrey Field Analyzer 30-2 or 24-2 SITA-Standard, ORA, and CST within 180 days were included in this multicentral, observational cross-sectional study. The association between ORA parameters (corneal hysteresis [CH] and corneal resistant factor [CRF]), CST parameters (A1 and A2 time, A1 and A2 length, A1 and A2 velocity, A1 and A2 deformation amplitude, highest deformation amplitude, highest concavity time, peak distance, and radius), and other basic parameters (age, intraocular pressure with Goldmann applanation tonometry, central corneal thickness, and axial length) against mean total deviation (mTD) were analyzed using a linear mixed-model and model selection with corrected Akaike Information Criterion (AICc).ResultsThe optimal model of VF severity included ORA's CH as well as a number of CST parameters, including A1 length, A2 time, radius, and highest concavity deformation amplitude (AICc: 971.7). The possibility this model describes visual field severity more accurately than the optimal model without CST parameters was 99.98%.ConclusionGlaucomatous VF severity was best described by both ORA and CST parameters. Eyes with corneas that experience sharp and deep indentation at the maximum deformation, wide indentation at the first applanation, and early second applanation in the CST measurement are more likely to show advanced VF severity.Translational RelevanceCorvisST tonometry parameters are related to VF severity in glaucoma patients.

Biomechanical Glaucoma Factor and Corneal Hysteresis in Treated Primary Open-Angle Glaucoma and Their Associations With Visual Field Progression

“…CH is an established risk factor for glaucoma development and progression. [5][6][7][8][9][10] In the present study, the AUC of CH was 0.71 and was significantly higher than that of BGF. Our results suggested that BGF is not useful in diagnosing POAG in the current population, which may be due to the broader background of glaucoma patients (POAG, not only NTG) in contrast to the original study in which BGF were developed, 12 as discussed later.…”

Relationship Between the Shift of the Retinal Artery Associated With Myopia and Ocular Response Analyzer Waveform Parameters

“…Another previous study reported that the maximum deformation amplitude measured by CST was associated with the size of β-zone parapapillary atrophy,16 which has been reported to be associated with the development, severity, progression, and location of glaucoma 17–20. Our recent studies also suggested that CST parameters were associated with the activity and prognosis of angioid streaks,21 and also the severity22 and progression23 of glaucoma. However, a different study reported no relationship between ORA-measured corneal hysteresis (CH) and β-zone parapapillary atrophy 24.…”

Repeatability of the Novel Intraocular Pressure Measurement From Corvis ST

“…Further, Hong et al37 reported that rapid visual field (VF) progression was more likely to occur in patients with high IOPcc, low CH, and a large recorded difference between IOPcc and GAT IOP. CST is a relatively new noncontact tonometry, and we have shown glaucomatous VF progression38 and also severity39 can be even better analyzed using CST-derived parameters (bIOP was not analyzed, because of the older software used). Albeit with the high repeatability suggested in the current study, bIOP may be useful to assess the progression of glaucomatous visual field (VF) progression.…”