Association between CLOCK gene polymorphisms and ADHD in Mexican teenagers: A comprehensive assessment

Cabrera-Lagunes, Alfonso; Díaz-Anzaldúa, Adriana; Andrade, Gustavo Rojas; Peschard, Vanessa-Giselle; Caballero, Adriana Arias; Gaspar-Barba, César Enrique; Jimenez, Arlette Yunes; Olvera, Francisco Rafael De la Peña; Fuentes, Carlos Sabas Cruz; Feria-Aranda, Miriam; Mora, Liz Sosa; Molina, Armando Pérez; Sanchez, Diana Guizar; Palacios‐Cruz, Lino

doi:10.1016/j.psychres.2022.114835

Cited by 1 publication

(1 citation statement)

References 63 publications

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“…This SNP, located in the 3′‐flanking region of the human CLOCK gene, was initially shown to be associated with delayed sleep timing (Mishima et al, 2005). Kissling et al (2008) were the first to report an association between 3111 T/C and ADHD symptoms, a finding later replicated in a combined Taiwanese and UK sample (Xu et al, 2010), in a sample of healthy male adults after assessing for ADHD‐related features (Jeong et al, 2014) and in a sample of Mexican adolescents (Cabrera Lagunes et al, 2022). Furthermore, a CLOCK haplotype, G‐A‐T‐G‐G‐C‐G‐A (rs534654, rs1801260, rs6855837, rs34897046, rs11931061, rs3817444, rs4864548 and rs726967), was associated with increased ADHD risk (Carpena et al, 2019); however, none of these SNPs were significant when analysed separately.…”

Section: Circadian Disruption As a Risk Factor For Nddsmentioning

confidence: 98%

The circadian system: A neglected player in neurodevelopmental disorders

Bouteldja,

Penichet,

Srivastava

et al. 2024

Eur J of Neuroscience

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Patients with neurodevelopmental disorders, such as autism spectrum disorder, often display abnormal circadian rhythms. The role of the circadian system in these disorders has gained considerable attention over the last decades. Yet, it remains largely unknown how these disruptions occur and to what extent they contribute to the disorders' development. In this review, we examine circadian system dysregulation as observed in patients and animal models of neurodevelopmental disorders. Second, we explore whether circadian rhythm disruptions constitute a risk factor for neurodevelopmental disorders from studies in humans and model organisms. Lastly, we focus on the impact of psychiatric medications on circadian rhythms and the potential benefits of chronotherapy. The literature reveals that patients with neurodevelopmental disorders display altered sleep–wake cycles and melatonin rhythms/levels in a heterogeneous manner, and model organisms used to study these disorders appear to support that circadian dysfunction may be an inherent characteristic of neurodevelopmental disorders. Furthermore, the pre‐clinical and clinical evidence indicates that circadian disruption at the environmental and genetic levels may contribute to the behavioural changes observed in these disorders. Finally, studies suggest that psychiatric medications, particularly those prescribed for attention‐deficit/hyperactivity disorder and schizophrenia, can have direct effects on the circadian system and that chronotherapy may be leveraged to offset some of these side effects. This review highlights that circadian system dysfunction is likely a core pathological feature of neurodevelopmental disorders and that further research is required to elucidate this relationship.

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