2019
DOI: 10.3892/etm.2019.7767
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Abstract: The role of cold inducible RNA-binding protein (CIRP) in mediating ischemic brain injury in neonatal rats under chronic hypobaric hypoxia was investigated. The neonatal rat model of chronic hypobaric hypoxia and the cell culture model of SH-SY5Y cells exposed to hypoxia (1% O 2 ) were constructed. The expression of CIRP and hypoxia-inducible factor-1α (HIF-1α) was detected after hypoxic exposure, and the apoptosis-related proteins were analyzed via terminal deoxynucleotidyl transferase-m… Show more

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Cited by 4 publications
(3 citation statements)
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References 21 publications
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“…Studies from our and other labs have undoubtedly shown that eCIRP is a major contributing factor causing neuroin ammation, neuronal injury and memory dysfunction in various settings [7,8,9,10,33,34].…”
Section: Discussionmentioning
confidence: 96%
See 1 more Smart Citation
“…Studies from our and other labs have undoubtedly shown that eCIRP is a major contributing factor causing neuroin ammation, neuronal injury and memory dysfunction in various settings [7,8,9,10,33,34].…”
Section: Discussionmentioning
confidence: 96%
“…The neurodegeneration and dysfunction is essentially caused by the deregulation of multiple complex and diverse signal transduction pathways, many of which are required for normal regulated functions, which get abnormally triggered or repressed [31,32]. Studies from our and other labs have undoubtedly shown that eCIRP is a major contributing factor causing neuroin ammation, neuronal injury and memory dysfunction in various settings [7,8,9,10,33,34].…”
Section: Discussionmentioning
confidence: 99%
“…The neurodegeneration and dysfunction is essentially caused by the deregulation of multiple complex and diverse signal transduction pathways, many of which are required for normal regulated functions, which get abnormally triggered or repressed [31,32]. Studies from our and other labs have undoubtedly shown that eCIRP is a major contributing factor causing neuroin ammation, neuronal injury and memory dysfunction in various settings [7,8,9,10,33,34].…”
Section: Discussionmentioning
confidence: 99%