Association between chronic spontaneous urticaria and thyroid autoimmunity: a case control study from a tertiary care centre

Abstract

<p class="abstract"><strong>Background:</strong> The exact etiology of chronic spontaneous urticaria is unknown in the majority of patients. A subset of chronic spontaneous urticaria can be autoimmune and may be associated with thyroid autoimmunity<span lang="EN-IN">.</span></p><p class="abstract"><strong>Methods:</strong> Serum anti thyroid peroxidase (anti-TPO) antibody level and thyroid function tests (TFT) including triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) levels were estimated in 100patients with chronic spontaneous urticaria and 50 controls. Autologous serum skin test (ASST) was done in 84 chronic urticaria patients and 21 patients with high anti-TPO antibody.<strong></strong></p><p class="abstract"><strong>Results:</strong> High anti-TPO antibodies and abnormal thyroid function were seen in 24 (24%) patients each. High anti-TPO antibody levels were seen in nine (18%) and abnormal TFT in 11 (22%) controls. Abnormal TSH was seen in 22 patients (22%) and 6 (12%) controls. Autologous serum skin test was positive in 53 patients with chronic spontaneous urticaria. It was positive in 16 and negative in five out of 21 patients with high anti-TPO antibody levels<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> Though there was a slight increase in abnormal anti-TPO antibody level and thyroid dysfunction in patients with chronic spontaneous urticaria compared to controls, it was not statistically significant<span lang="EN-IN">.</span></p>

Efficacy of the colchicine add‐on therapy in patients with autoimmune chronic urticaria

“…So, based on our results colchicine did not have any significant effect on anti‐TPO level. Similarly, Mariysth et al 14 showed that although there was a slight increase in abnormal anti‐TPO antibody level and thyroid dysfunction in patients with chronic spontaneous urticaria compared to controls, it was not statistically significant.…”

Study on Autoimmune Thyroid Disorders in Chronic Spontaneous Urticaria at a Tertiary Care Central Rural Hospital in India

“…Our results demonstrated that the triiodothyronine levels fell within the normal range for both groups. Similarly, Mariyath et al (2017) [ 11 ] conducted a study on 100 patients with chronic spontaneous urticaria and 50 controls, wherein the levels of serum anti-TPO antibodies, triiodothyronine (T3), tetraiodothyronine (T4), and TSH were estimated. The results showed that 22% of the patients had abnormal T3 and T4 levels, whereas 22% and 12% of the controls had abnormal TSH levels.…”

“…In contrast, the control group had an equal percentage of male and female participants. In another study by Mariyath et al (2017), out of 100 chronic urticaria patients, 75 were women and 25 were men, while the control group consisted of 12 men and 38 women [11].…”