Association Between CDKAL1, HHEX, CDKN2A/2B and IGF2BP2 Gene Polymorphisms and Susceptibility to Type 2 Diabetes in Uttarakhand, India

Verma, Amit Kumar; Goyal, Yamini; Bhatt, Deepti; Dev, Kapil; Alsahli, Mohammed A; Rahmani, Arshad Husain

doi:10.2147/dmso.s284998

Cited by 10 publications

(5 citation statements)

References 47 publications

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“… 16 Moreover, a significant relationship was observed among rs10440833 and T2DM risk under the recessive model in Indian. 30 For rs10946398, our study found that CC genotype was significantly associated with the increased risk of GDM, similar to the results of Zhang et al from another Chinese populations. 23 Zhang et al found that the insulin secretion index and insulin sensitivity index of CC genotype were significantly lower than those of AA genotype as well.…”

Section: Discussionsupporting

confidence: 91%

Association of theCDKAL1gene polymorphism with gestational diabetes mellitus in Chinese women

Huang

Guo

et al. 2023

BMJ Open Diab Res Care

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IntroductionTo identify the association of the cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1 (CDKAL1) gene polymorphism with gestational diabetes mellitus (GDM) in the Chinese population.Research design and methodsThis case-control study enrolled 835 pregnant women with GDM and 870 pregnant women without diabetes who underwent antenatal examination during 24 to 28 gestational weeks at the Maternal and Child Health Hospital of Hubei Province from January 15, 2018 to March 31, 2019. Trained nurses collected their clinical information and blood samples.CDKAL1gene rs10440833, rs10946398, rs4712523, rs4712524, rs7754840, rs7756992 and rs9465871 loci were genotyped by Agena MassARRAY system. SPSS V.26.0 software and online SHesis were used to analyze the relationship betweenCDKAL1gene polymorphism and GDM susceptibility.ResultsAfter being adjusted for maternal age, prepregnancy body mass index (BMI), parity and family history of type 2 diabetes mellitus (T2DM),CDKAL1gene rs10440833 (AA vs TT, OR=1.631, 95% CI 1.192 to 2.232), rs10946398 (CC vs AA, OR=1.400, 95% CI 1.028 to 1.905), rs4712523(GG vs AA, OR=1.409, 95% CI 1.038 to 1.913), rs4712524 (GG vs AA, OR=1.418, 95% CI 1.043 to 1.929) and rs7754840 (CC vs GG, OR=1.407, 95% CI 1.036 to 1.911) polymorphisms were all associated with the increased risk of GDM. In addition, there was a powerful linkage disequilibrium (LD) among rs10946398, rs4712523, rs4712524 and rs7754840 (D′>0.900, r2>0.900). And there were significant differences in haplotype CGGC (OR=1.207, 95% CI 1.050 to 1.387) and AAAG (OR=0.829, 95% CI 0.721 o 0.952, p=0.008) between the GDM group and the control group.Conclusionsrs10440833, rs10946398, rs4712523, rs4712524 and rs7754840 ofCDKAL1gene are associated with GDM susceptibility in central Chinese population.

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Section: Discussionsupporting

confidence: 91%

Association of theCDKAL1gene polymorphism with gestational diabetes mellitus in Chinese women

Huang

Guo

et al. 2023

BMJ Open Diab Res Care

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“…Our result show rs 1111875 polymorphism there is no significant difference between controls obese and patients obese genotype in any of the codominant, dominant, recessive, and additive model's genotypes. Some studies did not match our study in Dutch Breda cohort [22] southeast Iranian [14] In Potsdam, Germany [23], while our current study was identical to the study conducted in Uttarakhand, India [24]. Another study conducted on the Thai population showed no association between rs 1111875 located near gene HHEX and T2DM [25].…”

Section: Discussioncontrasting

confidence: 46%

Obesity-Related Type 2 Diabetes Mellitus and HHEX Gene rs1111875 C/T Polymorphisms in Iraqi Population.

Nisreen Qassem Shaker,

Seenaa Kadhum Ali

2023

J. K. Chem. Sci.

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type 2 diabetes mellitus(T2DM) is a complex metabolic disease. Diabetes mellitus has quadrupled globally in the last three decades. Many studies have shown how genetic diversity contributes to the development and progression of T2DM. The hematopoietic expressed homeobox (HHEX) gene is hypothesized to be linked to the risk of T2DM. The aim of this study was to look at the association of the HHEX gene polymorphism (rs1111875 C/T) with T2DM in the Iraqi population and see if obese individuals were affected more than other patients. Methods: 100 T2DM obese and 100 controls obese. The RFLP -PCR assay Technique was used to genotype HHEX rs1111875 C/T, making use of newly-designed primers. Results: The study's parameters demonstrate no significant difference between T2DM obese and obese control groups. The study concluded that there is no significant difference in genotypes Codominant, Dominant, Recessive, and Additive genotype between groups for HHEX rs1111875 C/T. and Chol, TG, and VLDL were significant between CC and CT, age was borderline. There is a negative relationship between (BMI and CHO and TG) and (insulin and HOMA-IR and LDL, VLDL). In conclusion, according to the findings of this study, the rs1111875 C/T polymorphism in the HHEX gene revealed no significant difference in genotypes in any of the codominant, dominant, recessive, or additive models.

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“…IGF2BP2 is involved in many biological processes by interacting with miRNAs, mRNAs and long non-coding RNAs to regulate various signalling pathways (16)(17). IGF2BP2 gene has been recognized to be linked with reduced secretion of insulin and B cell function (18). Genome-Wide Association Studies (GWAS) have shown that IGF2BP2 gene polymorphisms are also associated with pancreatic β-cell function and hyperglycaemia, and SNPs in the second intron of this gene are critical in the occurrence of T2D (13).…”

Section: Discussionmentioning

confidence: 99%

Investigation of Insulin-Like Growth Factor 2 mRNA Binding Protein 2 Gene Polymorphisms in Type 2 Diabetes Patients

Yolal Ertural,

Çınkır,

Aras

2024

Genel Tıp Dergisi

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Background/Aims: Type 2 diabetes (T2D) whose prevalance differs in different populations is a multifactorial disease. T2D is describes a group of clinical syndromes resulting from glucose metabolism disorders triggered by genetic or environmental factors. Insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) gene participates in insulin signaling pathway and is involved in insulin secretion. SNPs in one of these genes, IGF2BP2 gene (rs1470579 and rs4402960), have been reported to partially increase the risk of type II diabetes. The aim of this study was to investigate in a Turkish population identified associations of IGF2BP2 variants rs4402960 and rs1470579 with T2D. Methods: We genotyped two SNPs of IGF2BP2 gene, rs1470579 and rs4402960 in 100 healthy individuals and 100 patients. DNA isolation was performed on peripheral blood samples from patients and healthy groups. The molecular analysis of rs1470579 and rs4402960 polymorphisms of IGF2BP2 gene of each individual was performed by using Real-Time PCR (Applied Biosystems) method. Relationships of genotypes and alleles frequency of IGF2BP2 polymorphisms and T2D were examined by "Chi-square" or "Likelihood ratio" tests. Results: As a result of the genotype and allele distributions; there was association between type II diabetes patients and control group for IGF2BP2 rs1470579 (A/C) gene polymorphism (p=0.0123). The frequency of AC genotype in patients is more than the control group. However, there was no statistically significant difference genotype distribution between the type 2 diabetes patients and control group for IGF2BP2 rs4402960 (G/T) gene polymorphisms. There was no association between the patients and the control group for TT and GG+GT genotype distribution (p=0.8847). Conclusions: The results showed that the IGF2BP2 gene rs1470579 and rs4402960 polymorphisms were associated with T2D in a Turkish population (OR = 2.002, 95% CI 1.170–3.426, p < 0.05; OR = 1.879, 95% CI 1.110–3.182, p< 0.05). This is the first study between IGF2BP2 gene polymorphisms and type II diabetes in Turkish population. Keywords: IGF2BP2, T2D, Polymorphism

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Association Between CDKAL1, HHEX, CDKN2A/2B and IGF2BP2 Gene Polymorphisms and Susceptibility to Type 2 Diabetes in Uttarakhand, India

Cited by 10 publications

References 47 publications

Association of theCDKAL1gene polymorphism with gestational diabetes mellitus in Chinese women

Association of theCDKAL1gene polymorphism with gestational diabetes mellitus in Chinese women

Obesity-Related Type 2 Diabetes Mellitus and HHEX Gene rs1111875 C/T Polymorphisms in Iraqi Population.

Investigation of Insulin-Like Growth Factor 2 mRNA Binding Protein 2 Gene Polymorphisms in Type 2 Diabetes Patients

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