2022
DOI: 10.2147/cia.s356947
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Abstract: Background Chronic inflammation plays a key role in the pathophysiology of frailty and loss of physical performance, which are closely associated with sarcopenia. In women, the decline in muscle mass and strength is accelerated after menopause. Thus, we examined the association between high sensitivity C-reactive protein (hs-CRP) and relative handgrip strength (HGS) in postmenopausal women. Methods This cross-sectional study included 2171 postmenopausal women aged ≥45 y… Show more

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Cited by 7 publications
(9 citation statements)
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“…The results of this study are consistent with those of previous related studies [ 15 , 29 , 31 , 36 , 37 ] and, while proving that higher HGS is highly correlated with lower SII, we analyzed the nonlinear relationship between HGS and the SII using restricted cubic spline regression analysis to further explain the association. The physiological mechanisms related to the association between HGS, immune function, and inflammation are relatively complex.…”
Section: Discussionsupporting
confidence: 91%
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“…The results of this study are consistent with those of previous related studies [ 15 , 29 , 31 , 36 , 37 ] and, while proving that higher HGS is highly correlated with lower SII, we analyzed the nonlinear relationship between HGS and the SII using restricted cubic spline regression analysis to further explain the association. The physiological mechanisms related to the association between HGS, immune function, and inflammation are relatively complex.…”
Section: Discussionsupporting
confidence: 91%
“…Absolute values of HGS are closely related to body weight, and the use of it as an indicator of muscle strength, without correcting for body weight, may be an important reason for the contradictory results of many studies [ 29 , 30 , 32 , 34 ]. Several studies have shown that relative values of HGS are better than absolute grip strength in predicting some chronic diseases [ 18 , 29 , 30 ], so this study chose relative grip strength as the main independent variable to explore its potential association with the SII.…”
Section: Discussionmentioning
confidence: 99%
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