Association between benzodiazepines and recurrent falls: A cross-sectional elderly population-based study

Rossat, Arnaud; Fantino, Bruno; Bongué, Bienvenu; Colvez, Alain; Nitenberg, C.; Annweiler, Cédric; Beauchet, Olivier

doi:10.1007/s12603-010-0274-8

Cited by 7 publications

(11 citation statements)

References 30 publications

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“…Chronic pain (18,28,31,39,74) 5 Based on the results of the SLR and the proposal of NANDA-I for risk factors for falls in community-dwelling older people, we confirmed the multifactorial nature of risk factors that requires comprehensive, interdisciplinary, and multifactorial/multicomponent interventions (41,69) . Thus, our SLR contributes to the knowledge of nurses by transferring these findings to the clinical practice, which supports the provision of evidence-based nursing care.…”

Section: Physiologicalsupporting

confidence: 61%

“…The other countries with most articles were Canada (23,29,40,(65)(66)(67)(68) with seven, Netherlands (20,31,35,51,69) with five, and United Kingdom (48,(70)(71)(72) with four. Then came China (26,50,73) , France (45,49,74) and Sweden (37)(38)41) , with two, Ireland (75)(76) with one, and Germany (21) , Brazil (16) , Korea (26) , Spain (77) , Japan (22) , and Thailand (43) . Six of the selected studies are secondary (systematic literature reviews) and the remaining 56 are primary studies based on quantitative methodology, i.e.…”

Section: Resultsmentioning

confidence: 99%

“…This, and the guiding question, revealed that the risk factors for falls that are not listed in the NAN-DA-I are female (women are more prone to falls in the community) (20,38,40,59,63,(73)(74)77) , compromised activities of daily living (basic and instrumental) (16,22,25,31,33,(54)(55)63,70,73) , the fear of falling (30,(36)(37)(38)44,51,59,(62)(63)66,(70)(71)(72) , symptoms of depression/depression (18,30,43,45,51,59,63) , and lastly, low education (70) , low family income (70) , and ethnic minorities (70) . As for the level of evidence of these risk factors, we found that symptoms of depression/depression and female are mentioned in at least two papers , and compromised activities of daily living and fear of falling are mentioned in at least three random clinical trials (Ib evidence).…”

Section: Discussionmentioning

confidence: 99%

“…Age ≥ 65 years (50,61,63,73,74,77) 6 √ History of falls (28,50,53,57,63,67,69) 7 √ Living alone (63) 1 √ Lower limb prosthesis 0 √ Use of assistive devices (e.g. walker, cane, wheelchair) (17,41) 2 √ Female (20,38,40,59,63,73,74,77) 8…”

Section: Risk Factors N Nanda-i Adultsmentioning

confidence: 99%

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Risco de quedas em idosos residentes na comunidade: revisão sistemática da literatura

Sousa

Marques-Vieira

Caldevilla

et al. 2016

Rev. Gaúcha Enferm.

113

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Resultados: Obteve-se uma amostra de 62 estudos e um total de 50 fatores de risco, dos quais, apenas 38 estão presentes na classificação. Conclusões:São propostas duas novas categorias de fatores: os psicológicos e socioeconômicos. Foram identificados novos fatores de risco de queda dos idosos residentes na comunidade, o que contribui para a atualização deste diagnóstico na taxonomia II da NANDA Internacional. Resultados: Fueron seleccionados 62 artículos en los cuales se identificaron 50 factores de riesgo, de los que apenas 38 están presentes en la NANDA Internacional. Palavras Conclusiones:Se proponen dos nuevas categorías de factores: los psicológicos y los socioeconómicos. Se identificaron nuevos factores de riesgo de caídas en los ancianos residentes en la comunidad, lo que contribuyó para la actualización de la taxonomía II NANDA Internacional.Palabras clave: Accidentes por caídas. Factores de riesgo. Diagnóstico de enfermería. Anciano.

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Section: Physiologicalsupporting

confidence: 61%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Risk Factors N Nanda-i Adultsmentioning

confidence: 99%

See 2 more Smart Citations

Risco de quedas em idosos residentes na comunidade: revisão sistemática da literatura

Sousa

Marques-Vieira

Caldevilla

et al. 2016

Rev. Gaúcha Enferm.

113

View full text Add to dashboard Cite

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“…5 Patients with opioid use disorders have a higher risk of overdose death-both suicide and non-suicide-when taking benzodiazepines. 6,7,35 Senior patients are particularly vulnerable, because benzodiazepines are associated with falls, [36][37][38][39] hip fractures, 12 delirium, 10,11 disability, 13 dementia, 14,15 and motor vehicle accidents. 40 Osteoporosis has been linked to fractures alongside benzodiazepine prescriptions in The referent for odds ratios for diagnoses and other prescriptions is patients who did not have that diagnosis or prescription patients at risk of falls, although no direct relationship between osteoporosis and benzodiazepine prescriptions has been described.…”

Section: Discussionmentioning

confidence: 99%

Benzodiazepines are Prescribed More Frequently to Patients Already at Risk for Benzodiazepine-Related Adverse Events in Primary Care

et al. 2016

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BACKGROUND: Benzodiazepine use is associated with adverse drug events and higher mortality. Known risk factors for benzodiazepine-related adverse events include lung disease, substance use, and vulnerability to fracture. OBJECTIVE: To determine whether benzodiazepine prescribing is associated with risk factors for adverse outcomes. DESIGN: Longitudinal cohort study between July 1, 2011, and June 30, 2012. PARTICIPANTS: Patients who visited hospital-and community-based practices in a primary care practicebased research network. MAIN MEASURES:Odds ratio of having a target medical diagnosis for patients who received standard and highdose benzodiazepine prescriptions; rates per 100 patients for outpatient and emergency department visits and hospitalizations. KEY RESULTS: Among 65,912 patients, clinicians prescribed at least one benzodiazepine to 15 % (9821). Of benzodiazepine recipients, 5 % received high doses. Compared to non-recipients, benzodiazepine recipients were more likely to have diagnoses of depression (OR, 2.7; 95 % CI, 2.6-2.9), substance abuse (OR, 2.2; 95 % CI, 1.9-2.5), tobacco use (OR, 1.7; 95 % CI, 1.5-1.8), osteoporosis (OR, 1.6; 95 % CI, 1.5-1.7), chronic obstructive pulmonary disease (OR, 1.6; 95 % CI, 1.5-1.7), alcohol abuse (OR, 1.5; 95 % CI, 1.3-1.7), sleep apnea (OR, 1.5; 95 % CI, 1.3-1.6), and asthma (OR, 1.5; 95 % CI, 1.4-1.5). Compared to low-dose benzodiazepine recipients, high-dose benzodiazepine recipients were even more likely to have certain medical diagnoses: substance abuse (OR, 7.5; 95 % CI, 5.5-10.1), alcohol abuse (OR, 3.2; 95 % CI, 2.2-4.5), tobacco use (OR, 2.7; 95 % CI, 2.1-3.5), and chronic obstructive pulmonary disease (OR, 1.5; 95 % CI, 1.2-1.9).Benzodiazepine recipients had more primary care visits per 100 patients (408 vs. 323), specialist outpatient visits (815 vs. 578), emergency department visits (47 vs. 29), and hospitalizations (26 vs. 15; p < .001 for all comparisons). CONCLUSIONS: Clinicians prescribed benzodiazepines and high-dose benzodiazepines more frequently to patients at higher risk for benzodiazepine-related adverse events. Benzodiazepine prescribing was associated with increased healthcare utilization.

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Trends in prescribing of sedative‐hypnotic medications in the USA: 1993–2010

Kaufmann

Spira

Alexander

et al. 2015

Pharmacoepidemiology and Drug

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PURPOSE Non-benzodiazepine receptor agonists (nBZRAs) were developed as an alternative to benzodiazepines (BZDs) to treat insomnia. Little is known how the introduction of nBZRAs influenced trends in BZD prescribing. We examined BZD and nBZRA prescribing trends from 1993 to 2010. METHODS We used the National Ambulatory Medical Care Survey to examine 516,118 patient visits between 1993 and 2010. We categorized visits as BZD, nBZRA, or BZD+nBZRA visits based on medications prescribed each visit and applied linear probability regression models to assess trends in visits. RESULTS Increases were observed in proportions of visits that were BZD (2.6% in 1993 to 4.4% in 2010, p<0.001) and nBZRA (0% to 1.4%, p<0.001). Increases in BZD visits were primarily after 2002, with prescribing in the preceding years remaining relatively stable. We also found increases in BZD+nBZRA visits (0% to 0.4%, p<0.001). Among patients with sleep disorders, there was an increase in nBZRA visits (2.3% to 13.7%, p<0.001), and decline in BZD visits (23.5% to 10.8%, p=0.015). Just under a third (30.8%) of any-sedative hypnotic visits were for adults aged 65+, among whom increases in BZD, nBZRA, and BZD+nBZRA visits were observed across the study period. CONCLUSIONS There were increases in prescribing of nBZRAs between 1993 and 2010. Increases in prescribing of BZDs were also observed, especially after 2002. The introduction of nBZRAs likely resulted in declines in BZD prescribing among those with a sleep disorder, but not other groups. Delivery of behavioral treatments should be encouraged to avert adverse outcomes associated with sedative-hypnotic use.

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Association between benzodiazepines and recurrent falls: A cross-sectional elderly population-based study

Cited by 7 publications

References 30 publications

Risco de quedas em idosos residentes na comunidade: revisão sistemática da literatura

Risco de quedas em idosos residentes na comunidade: revisão sistemática da literatura

Benzodiazepines are Prescribed More Frequently to Patients Already at Risk for Benzodiazepine-Related Adverse Events in Primary Care

Trends in prescribing of sedative‐hypnotic medications in the USA: 1993–2010

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