Association between ABO blood groups and clinical outcome of coronavirus disease 2019: Evidence from two cohorts

Zeng, Xianfei; Fan, H. Christina; Lyu, Deguo; Huang, Fang; Meng, Xi; Li, Zhuo; Tang, Mei Tzu C; Zhang, Jing; Liu, Nannan; Liu, Zhixin; Zhao, Jingya; Yin, Wen; An, Qing; Zhang, Xijing; Hu, Xingbin

doi:10.1101/2020.04.15.20063107

Cited by 57 publications

(79 citation statements)

References 31 publications

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“…The frequency of blood group A in COVID-19 patients was significantly higher compared to the non-COVID-19 group. In a study conducted by Zeng et al (10), 35% of the patients with mild pneumonia and 39% of the patients with severe pneumonia had blood group A. These patients had a higher frequency of blood group A compared to the general population.…”

Section: Discussionmentioning

confidence: 94%

The Relationship Between Blood Groups and COVID-19 Patients

Çakır¹

2020

Erciyes Med J

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Objective: The present research aims to evaluate the relationship between blood groups and COVID-19 patients. Materials and Methods: This is a descriptive study, and data of 256 patients with COVID-19 positive were evaluated. In the analysis, the level of statistical significance was accepted as p<0.05. Results: In this research, 62.1% of the patients examined were male, 75.4% were married; 34.8% were in the 30-39 age group, 23.8% were in the 40-49 age group, and the mean age was 37.0±12.2. 33.3% of the patients were high school graduates, 32.9% were primary school graduates, 44.1% had blood group A Rh+, and 21.5% had blood group 0 Rh+. In this research, the findings showed that 85.9% of the patients had symptoms, 49.6% had malaise, 48.0% had joint pain, 32.0% had a history of a positive family member or a positive relative before themselves, and 42.2% had a history of positive case at the workplace before themselves. Conclusion: In this research, the frequency of the blood group A Rh+ was high and the frequency of the blood group 0 Rh+ was low in COVID-19 patients. The mean age of the patients was 37, and number of the patients who needed intensive care was low. There was no difference between the symptom states, according to blood groups. It is recommended that people with blood type A behave more sensitively in terms of following the protection measures.

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Section: Discussionmentioning

confidence: 94%

The Relationship Between Blood Groups and COVID-19 Patients

Çakır¹

2020

Erciyes Med J

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“…In the first study by Zeng et al has reported in their preprint that their retrospective study examined 265 COVID-19 patients from multiple medical centres and two established cohorts, where they found that the blood type A population was more sensitive to SARS-CoV-2. 29 Their findings are indicative of coping with the great threat since it probed the relationship between blood types and ARDS, acute kidney injury, and mortality, in addition to susceptibility in COVID-19 patients. 29 In another independent GWAS study by an Italian and a Spanish group, Ellinghaus et al which included 1,600 COVID-19 patients in hotspot cities in Italy and Spain has also shown that those with blood group A were at a higher risk while those with O were protected to some degree.…”

Section: Abo Blood Groups Are Associated With Susceptibility To Develmentioning

confidence: 99%

“…29 Their findings are indicative of coping with the great threat since it probed the relationship between blood types and ARDS, acute kidney injury, and mortality, in addition to susceptibility in COVID-19 patients. 29 In another independent GWAS study by an Italian and a Spanish group, Ellinghaus et al which included 1,600 COVID-19 patients in hotspot cities in Italy and Spain has also shown that those with blood group A were at a higher risk while those with O were protected to some degree. 30 They have discovered at least a couple of significant associations, including one that located at the ABO blood group locus.…”

Section: Abo Blood Groups Are Associated With Susceptibility To Develmentioning

confidence: 99%

Current Insights into the Novel Coronavirus Disease 2019 (COVID-19) and Its Homoeopathic Management

Dey

Sihag

2020

Homœopathic Links

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new coronavirus strain that has not been ever found in humans before December 2019. Both the coronavirus disease 2019 (COVID-19) case fatality rate and deaths per million population in the top 10 affected countries are increasing a lot due to ever-increasing number of new cases among countries facilitated by increased affinity of SARS-CoV-2 to bind human angiotensin-converting enzyme 2 (ACE2) receptors. While human-to-human transmission of SARS-CoV-2 happens through close contact with an infected individual who spreads respiratory droplets through air or other means, its diagnosis relies mainly on detection of nucleic acid. Repurposing drugs such as dexamethasone, remdesivir, favipiravir and TMPRSS2 (trans membrane protease, serine 2) protease inhibitors have been shown to be effective for the treatment of COVID-19 with albeit requirement of further studies to conclude their complete effectiveness. Personal protective measures should be followed to prevent SARS-CoV-2 infection. Additionally, hundreds of clinical trials of vaccines against SARS-CoV-2 are undergoing, while plasma therapy from the COVID-19 survivors is also being tried to treat the severely affected patients. In addition to these aforementioned modern medicines and therapeutic approaches, homoeopathy also holds promising anti-viral effect as evident from its success against flu and other epidemics, historically. Therefore, present article provides a glimpse of advancements made in the area of homoeopathic ways of treating COVID-19 by summarising the recent homoeopathic clinical, research trials and future scopes of homoeopathy to combat the pandemic. After critical review of most of the ongoing or recently completed homoeopathic treatment efforts against SARS-CoV-2, it was identified that Bryonia alba, Arsenicum album and Gelsemium sempervirens are working best among homoeopathic medicines till now. These studies are also suggesting an increased application of these remedies to treat the current pandemic worldwide; therefore, more such studies are warranted. Those further research will pave the way to understand the mechanism of each of these homoeopathic drugs to cure COVID-19 facilitated by optimising their doses, effects and find the best among these multiple options in homoeopathic medicines for plausible mono- or combination therapies.

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“…In another study from China, a report by Zeng et al comparing a cohort of COVID-19 patients with mild symptoms to another with severe symptoms, showed higher proportions of patients with blood group A in both groups (36% and 39% respectively), compared to a reference population, confirming that individuals with blood group type A were more susceptible to COVID-19 infection. [6] The calculated OD was 1.40 (95% CI:…”

Section: Introductionmentioning

confidence: 99%

ABO Blood Group Type and Susceptibility to COVID-19 Infection

Fernandez-Botran¹

2020

JRI

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Since December 2019, the SARS-CoV2 (COVID-19) pandemic has continued to extend over most of the world, infecting over four million people and causing well over 300,000 deaths so far (https://coronavirus.jhu.edu/map.html, accessed on May 14, 2020). A significant percentage of infected patients develop severe symptoms and life-threatening conditions. While COVID-19 infection can affect all ages, available evidence points to older age and pre-existing comorbidities such as hypertension, diabetes and coronary heart disease, as important risk factors related to increased mortality rates. [1-3] Moreover, recent reports from China and the U.S. have suggested that the susceptibility, and perhaps even mortality, to Covid-19 infection might be influenced by the ABO blood type. The purpose of the present minireview is to analyze the evidence published in the COVID-19 literature and to put it in the context of the existing knowledge about the association of blood group types and disease.

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Association between ABO blood groups and clinical outcome of coronavirus disease 2019: Evidence from two cohorts

Cited by 57 publications

References 31 publications

The Relationship Between Blood Groups and COVID-19 Patients

The Relationship Between Blood Groups and COVID-19 Patients

Current Insights into the Novel Coronavirus Disease 2019 (COVID-19) and Its Homoeopathic Management

ABO Blood Group Type and Susceptibility to COVID-19 Infection

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