2015
DOI: 10.18632/aging.100841
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Abstract: Reduced insulin/insulin-like growth factor 1 (IGF-1) signaling has been associated with longevity in various model organisms. However, the role of insulin/IGF-1 signaling in human survival remains controversial. The aim of this study was to test whether circulating IGF-1 axis parameters associate with old age survival and functional status in nonagenarians from the Leiden Longevity Study. This study examined 858 Dutch nonagenarian (males≥89 years; females≥91 years) siblings from 409 families, without selection… Show more

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Cited by 44 publications
(42 citation statements)
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References 34 publications
(38 reference statements)
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“…Our group demonstrated that lower IGF-1 levels can predict extended survival in Ashkenazi Jewish female nonagenarians and nonagenarians of both sexes with a history of cancer (Milman et al, 2014). In Dutch nonagenarians of both sexes, the hazard of death was 27% lower among those with IGF-1/IGFBP-3 ratios in the first quartile compared to those in the fourth quartile (van der Spoel et al, 2015). Furthermore, those with the lowest IGF-1/IGFBP-3 demonstrated higher scores on performance of activities of daily living (ADL) (van der Spoel et al, 2015).…”
Section: Human “Models” Of Gh/igf-1 Attenuation and Agingmentioning
confidence: 97%
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“…Our group demonstrated that lower IGF-1 levels can predict extended survival in Ashkenazi Jewish female nonagenarians and nonagenarians of both sexes with a history of cancer (Milman et al, 2014). In Dutch nonagenarians of both sexes, the hazard of death was 27% lower among those with IGF-1/IGFBP-3 ratios in the first quartile compared to those in the fourth quartile (van der Spoel et al, 2015). Furthermore, those with the lowest IGF-1/IGFBP-3 demonstrated higher scores on performance of activities of daily living (ADL) (van der Spoel et al, 2015).…”
Section: Human “Models” Of Gh/igf-1 Attenuation and Agingmentioning
confidence: 97%
“…In Dutch nonagenarians of both sexes, the hazard of death was 27% lower among those with IGF-1/IGFBP-3 ratios in the first quartile compared to those in the fourth quartile (van der Spoel et al, 2015). Furthermore, those with the lowest IGF-1/IGFBP-3 demonstrated higher scores on performance of activities of daily living (ADL) (van der Spoel et al, 2015). Such evidence suggests that diminished function of the GH/IGF-1 axis may be beneficial to human aging and promotes longevity by conferring protection against age-related diseases and dysfunction.…”
Section: Human “Models” Of Gh/igf-1 Attenuation and Agingmentioning
confidence: 97%
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“…Air pollution in Cairo is considered one of the greatest challenges to health in Egypt because of its multiple sources, including industrial waste, burning of agricultural residues, vehicle emissions and pollutants resulting from open burning of municipal solid waste (9). The study compared respiratory function between schoolchildren in an urban area (Cairo) and a rural area (Shibin El-Kom) of Egypt and also explored the relative importance of an urban-rural setting and other known risk factors in relation to respiratory function.…”
Section: Introductionmentioning
confidence: 99%