Association among XRCC1, XRCC3, and BLHX gene polymorphisms and chromosome instability in lymphocytes from patients with endometriosis and ovarian cancer

Monteiro, Maria S.; Boas, D. B. Vilas; Gigliotti, Chiara; Salvadori, Daisy Maria Fávero

doi:10.4238/2014.january.28.9

Cited by 22 publications

(16 citation statements)

References 36 publications

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“…Of the 24 studies related to rs25487, 16 focused on cervical cancer [14–29], 5 on endometrial cancer [30–34], and 3 on ovarian cancer [35–37]. The ethnic group was Asian in 11 studies and Non-Asian in the others.…”

Section: Resultsmentioning

confidence: 99%

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Meta-analysis of XRCC1 polymorphism and risk of female reproductive system cancer

et al. 2017

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Numerous epidemiological studies have evaluated the association between polymorphism in the gene encoding x-ray repair cross complementing 1 (XRCC1) protein and the risk of female reproductive system cancer, but results are inconclusive. To gain a comprehensive picture of available evidence, we searched for relevant studies in the PubMed, EMBASE, Scopus, and Chinese National Knowledge Infrastructure databases up to December 17, 2016. A total of 26 case-control studies were picked out. The pooled odds ratio (OR) with its 95% confidence interval (CI) was calculated to estimate the association. Based on data of all study participants, we did not find a positive association of rs25487 or rs1799782 polymorphism with risk of female reproductive cancer risk. Subgroup analysis, however, identified two alleles as being associated with an increased risk of female reproductive system cancer in Asians: the A allele of rs25487 (heterozygous genetic model, OR 1.16, 95%CI 1.00–1.36), and the T allele of rs1799782 (homozygous model, OR 2.30, 95%CI 1.39–3.82; dominant model, OR 1.28, 95%CI 1.10–1.50; recessive model, OR 2.11, 95%CI 1.33–3.34). Moreover, the AA genotype at rs25489 was determined to be a risk factor for cervical cancer etiology (homozygous model, OR 2.91, 95%CI, 1.17–7.26; recessive model, OR 3.16, 95%CI 1.91–5.24). This meta-analysis suggests that no association between rs25487 or rs1799782 gene polymorphism and risk of female reproductive cancer risk was found. These results should be validated in larger studies.

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Section: Resultsmentioning

confidence: 99%

“…The ethnic group was Asian in 11 studies and Non-Asian in the others. Of the 15 studies related to rs1799782, 10 focused on cervical cancer [16–20, 25, 27, 28], 3 on endometrial cancer [35, 37, 38], and 2 on ovarian cancer [30, 31]. The ethnic group was Asian in 7 studies and Non-Asian in 8 studies.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of XRCC1 polymorphism and risk of female reproductive system cancer

et al. 2017

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“…ERCC2 is involved in DNA repair, specifically in nucleotide excision repair. It functions in various types of DNA lesions [12]. Both XRCC2 and ERCC2 are identified as DNA repair genes.…”

Section: Discussionmentioning

confidence: 99%

Associations between XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms and ovarian cancer

Zhang

2016

Oncotarget

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Recent studies explored XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms and ovarian cancer (OC) risk. However, the association between these two single nucleotide polymorphisms and OC risk remains conflicting. Thus, we conducted a comprehensive systematic review and meta-analysis to investigate the association. We searched the databases of PubMed, and Embase. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by using fixed-effect or random-effect models. 15 case-control studies published in 11 papers including 4,757 cases and 8,431 controls were included in this meta-analysis. No associations were obtained between XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms and OC risk. Stratification analyses of Hardy–Weinberg equilibrium status indicated that rs3218536 polymorphism was associated with the decreased risk of OC when in analysis of combined HWE positive studies. In conclusion, this meta-analysis indicates that XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms may not be associated with the risk of OC.

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“…1 – 4 XRCC genes are involved in base excision repair (BER) and single-strand break in damaged DNA in human genome. 1 – 5 Molecular epidemiological studies have shown that XRCC genes are significantly associated with lung cancer, 6 – 9 oral cancer, 10 bladder cancer, 11 – 13 ovarian cancer, 14 , 15 esophageal cancer, 16 and gastric cancer. 17 – 23 Moreover, studies have revealed that XRCC gene polymorphism is highly variable in different ethnic populations.…”

Section: Introductionmentioning

confidence: 99%

DNA Repair Mechanism Gene,XRCC1A(Arg194Trp) but notXRCC3(Thr241Met) Polymorphism Increased the Risk of Breast Cancer in Premenopausal Females: A Case–Control Study in Northeastern Region of India

Devi

Ahmed

Narain

et al. 2017

Technol Cancer Res Treat

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X-ray repair cross complementary group gene is one of the most studied candidate gene involved in different types of cancers. Studies have shown that X-ray repair cross complementary genes are significantly associated with increased risk of breast cancer in females. Moreover, studies have revealed that X-ray repair cross complementary gene polymorphism significantly varies between and within different ethnic groups globally. The present case–control study was aimed to investigate the association of X-ray repair cross complementary 1A (Arg194Trp) and X-ray repair cross complementary 3 (Thr241Met) polymorphism with the risk of breast cancer in females from northeastern region of India. The present case–control study includes histopathologically confirmed and newly diagnosed 464 cases with breast cancer and 534 apparently healthy neighborhood community controls. Information on sociodemographic factors and putative risk factors were collected from each study participant by conducting face-to-face interviews. Genotyping of X-ray repair cross complementary 1A (Arg194Trp) and X-ray repair cross complementary 3 (Thr241Met) was carried out by polymerase chain reaction-restriction fragment length polymorphism. For statistical analysis, both univariate and multivariate logistic regression analyses were performed. We also performed stratified analysis to find out the association of X-ray repair cross complementary genes with the risk of breast cancer stratified based on menstrual status. This study revealed that tryptophan allele (R/W-W/W genotype) in X-ray repair cross complementary 1A (Arg194Trp) gene significantly increased the risk of breast cancer (adjusted odds ratio = 1.44, 95% confidence interval = 1.06-1.97, P < .05 for R/W-W/W genotype). Moreover, it was found that tryptophan allele (W/W genotype) at codon 194 of X-ray repair cross complementary 1A (Arg194Trp) gene significantly increased the risk of breast cancer in premenopausal females (crude odds ratio = 1.66, 95% confidence interval = 1.11-2.46, P < .05 for R/W-W/W genotype). The present study did not reveal any significant association of X-ray repair cross complementary 3 (Thr241Met) polymorphism with the risk of breast cancer. The present study has explored that X-ray repair cross complementary 1A (Arg194Trp) gene polymorphism is significantly associated with the increased risk of breast cancer in premenopausal females from northeastern region of India which may be beneficial for prognostic purposes.

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Association among XRCC1, XRCC3, and BLHX gene polymorphisms and chromosome instability in lymphocytes from patients with endometriosis and ovarian cancer

Cited by 22 publications

References 36 publications

Meta-analysis of XRCC1 polymorphism and risk of female reproductive system cancer

Meta-analysis of XRCC1 polymorphism and risk of female reproductive system cancer

Associations between XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms and ovarian cancer

DNA Repair Mechanism Gene,XRCC1A(Arg194Trp) but notXRCC3(Thr241Met) Polymorphism Increased the Risk of Breast Cancer in Premenopausal Females: A Case–Control Study in Northeastern Region of India

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