“…Among the main pathophysiological findings in CF, lung function severity is considered an important mortality and morbidity marker. 3,18,19 Thus, a more severely impaired lung function is commonly associated with a worse metabolic, nutritional and digestive function, which in turn, may explain the correlations found in our study between the pulmonary function variables, CFQ-R domains and the 6MWT results. The worsening of lung function associated with reduced exercise tolerance starts a vicious cycle where the patient abstains from physical activity, resulting in progressive deconditioning and increased dyspnoea.…”