Biochemical Pharmacology volume 80, issue 2, P160-169 2010 DOI: 10.1016/j.bcp.2010.03.017 View full text
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Tanguy Araud, Susan Wonnacott, Daniel Bertrand

Abstract: Ligand gated ion channels are integral multimeric membrane proteins that can detect with high sensitivity the presence of a specific transmitter in the extracellular space and transduce this signal into an ion flux. While these receptors are widely expressed in the nervous system, their expression is not limited to neurons or their postsynaptic targets but extends to non-neuronal cells where they participate in many physiological responses. Cells have developed complex regulatory mechanisms allowing for the pr…

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