Assessment of vascular endothelial growth factor in systemic lupus erythematosus patients with anti-phospholipid syndrome

El‐Gazzar, Iman I.; Ibrahim, Saad M.; El-Sawy, Wael S.; Fathi, Hanan M.; Eissa, Amal H.

doi:10.1016/j.ejr.2018.03.005

Cited by 7 publications

(4 citation statements)

References 30 publications

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“…Reduced TSP-1 was detected in patients with severe clinic manifestations in SLE [ 37 ]. Recent studies evaluating the association between MMPs and renal function in LN showed a strong correlation of MMP2 expression in glomeruli and increased SLE activity scores with decreased renal function [ 38 , 39 , 40 ]. Changes in the expression and activity of MMPs have been described in a number of glomerulopathies.…”

Section: Discussionmentioning

confidence: 99%

The Inflammatory Profile Orchestrated by Inducible Nitric Oxide Synthase in Systemic Lupus Erythematosus

Ene

Nicolae

2023

JPM

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(1) Background: The pathogenesis of systemic lupus erythematosus (SLE) involves complicated and multifactorial interactions. Inducible nitric oxide synthase overactivation (iNOS or NOS2) could be involved in SLE pathogenesis and progression. This study explored the relationship between NOS2-associated inflammation profiles and SLE phenotypes. (2) Methods: We developed a prospective, case control study that included a group of 86 SLE subjects, a group of 73 subjects with lupus nephritis, and a control group of 60 people. Laboratory determinations included serum C reactive protein (CRP–mg/L), enzymatic activity of NOS2 (U/L), serum levels of inducible factors of hypoxia 1 and 2 (HIF1a–ng/mL, HIF2a–ng/mL), vascular endothelial growth factor VEGF (pg/mL), matrix metalloproteinases 2 and 9 (MMP-2, MMP-9–ng/mL), thrombospondin 1 (TSP-1–ng/mL), and soluble receptor of VEGF (sVEGFR–ng/mL). (3) Results: CRP, NOS2, HIF-1a, HIF-2a, VEGF, MMP-2, and MMP-9 were significantly increased, while TSP-1 and sVEGFR were decreased in the SLE and lupus nephritis groups compared with the control group. The variations in these biomarkers were strongly associated with the decrease in eGFR and increase in albuminuria. (4) Conclusions: The inflammatory phenotype of SLE patients, with or without LN, is defined by NOS2 and hypoxia over-expression, angiogenesis stimulation, and inactivation of factors that induce resolution of inflammation in relation with eGFR decline.

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Section: Discussionmentioning

confidence: 99%

The Inflammatory Profile Orchestrated by Inducible Nitric Oxide Synthase in Systemic Lupus Erythematosus

Ene

Nicolae

2023

JPM

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“…These findings indicate that the serum level of VEGF may be a useful marker of disease activity and internal organ damage [ 14 ]. VEGF levels were also assessed in another study that included 84 women with SLE, 37 of them with antiphospholipid syndrome, along with 33 matched controls [ 15 ]. In this study, VEGF levels showed a statistically significant correlation with SLEDAI, and VEGF levels were also higher in anti-DNA positive patients.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, VEGF levels showed a statistically significant correlation with SLEDAI, and VEGF levels were also higher in anti-DNA positive patients. However, no association was found with antiphospholipid syndrome [ 15 ]. Our study included a larger series of patients and evaluated a number of disease-related manifestations, not only those associated with disease activity, but also damage and severity, cardiovascular comorbidity, or subclinical carotid atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Vascular Endothelial Growth Factor and Its Soluble Receptor in Systemic Lupus Erythematosus Patients

et al. 2022

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Vascular endothelial growth factor (VEGF) is a major regulator of physiological and pathological angiogenesis. Its soluble receptor (sVEGFR) is a potent VEGF antagonist. Systemic lupus erythematosus (SLE) is an autoimmune disease with a diverse array of clinical manifestations that affect virtually any organ. We aimed to analyze the relationship of VEGF and sVEGFR with SLE disease-related features including disease activity, damage, and severity. Serum levels of VEGF165 isoform and sVEGFR (receptor 1) were assessed in 284 well-characterized patients with SLE. Linear regression analysis was performed to analyze the relationship of disease characteristics with both VEGF and sVEGFR. Patients with a disease damage index (SLICC score) equal to or greater than 1 had significantly elevated serum levels of VEGF and sVEGFR. Regarding disease-specific features, musculoskeletal manifestations were the disease feature most commonly associated with the upregulation of both VEGF and sVEGFR. SLE disease damage is associated with higher levels of VEGF and sVEGFR.

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“…VEGF may have a role in the pathogenesis of SLE, and as its concentration appears to be a measure of activity, it may be useful for disease monitoring and therapy planning. 12 In individuals with knee osteoarthritis, serum and synovial Vascular Endothelial Growth Factor (VEGF) levels were linked to clinical, functional, radiographic, and ultrasound (U/S) severity. 13 The VEGF family includes placental growth factor, VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and VEGF-F. 14 On chromosome 6p12, the VEGF gene is present.…”

Section: Introductionmentioning

confidence: 99%

The genetic influence of VEGFA single nucleotide polymorphism (SNP) (rs1570360) on the risk, disease activity, and severity in systemic lupus erythematosus patients.

Ali

Mohamed

Hassan

et al. 2022

Al-Azhar International Medical Journal

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Background: SLE is a chronic autoimmune illness in which numerous variables, including epigenetic, genetic, and environmental factors, interact to determine disease risk. The role of the VEGF single nucleotide polymorphism (SNP) in SLE patients was assessed in the current study. Aim of The Work: TO determine whether the vascular endothelial growth factor (VEGF) 1154G/A single nucleotide polymorphism (SNP) is associated with systemic lupus erythematosus (SLE) risk & disease activity. Patients and Methods:The study included 50 SLE patients and 50 healthy controls. Full clinical assessment and laboratory investigations were done for the SLE patients. For both patients and controls, the (VEGF) 1154G/A SNP was detected using real-time PCR. Systemic

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Assessment of vascular endothelial growth factor in systemic lupus erythematosus patients with anti-phospholipid syndrome

Cited by 7 publications

References 30 publications

The Inflammatory Profile Orchestrated by Inducible Nitric Oxide Synthase in Systemic Lupus Erythematosus

The Inflammatory Profile Orchestrated by Inducible Nitric Oxide Synthase in Systemic Lupus Erythematosus

Vascular Endothelial Growth Factor and Its Soluble Receptor in Systemic Lupus Erythematosus Patients

The genetic influence of VEGFA single nucleotide polymorphism (SNP) (rs1570360) on the risk, disease activity, and severity in systemic lupus erythematosus patients.

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