Assessment of Tissue Oxidative Stress, Antioxidant Parameters, and Zinc and Copper Levels in Patients with Breast Cancer

Barartabar, Zeinab; Moini, Nazi; Abbasalipourkabir, Roghayeh; Mesbah‐Namin, Seyed Alireza; Ziamajidi, Nasrin

doi:10.1007/s12011-022-03439-5

Cited by 5 publications

(6 citation statements)

References 44 publications

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“…A 2022 study by Mansouri et al [ 28 ] reported that higher zinc levels were present in mammary tissue from healthy individuals than in breast cancer tissue from patients. In contrast, in a 2022 study of breast cancer patients, Barartabar et al [ 29 ] reported lower zinc levels in adjacent non-cancerous areas compared with breast cancer tissue. This apparent discrepancy should be interpreted with caution, as Mansouri et al assessed zinc levels in tissue from breast cancer patients compared with healthy controls, while Barartabar et al examined zinc levels in healthy and diseased tissue from the same patient; thus, the studies may not be comparable.…”

Section: Introductionmentioning

confidence: 93%

Zinc Deficiency as a General Feature of Cancer: a Review of the Literature

Sugimoto,

Lee,

Tanaka

et al. 2023

Biol Trace Elem Res

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Trace elements are minerals that are present in very low concentrations in the human body and yet are crucial for a wide range of physiological functions. Zinc, the second most abundant trace element, is obtained primarily from the diet. After being taken up in the intestine, zinc is distributed to various target organs, where it plays key roles in processes such as immunity, protein folding, apoptosis, and antioxidant activity. Given the important role of zinc in a wide range of enzymatic reactions and physiological processes, zinc deficiency has been identified in a variety of diseases, notably cancer. In recent years, multiple meta-analyses and reviews looking at zinc levels in individual cancer types have been published, as have a plethora of primary studies demonstrating a link between low zinc levels and specific types of cancer. In this review, we summarize recent evidence implicating low zinc concentrations in serum or tissues as a characteristic in a wide range of cancers. We also discuss preliminary findings indicating that zinc level measurement could ultimately become a useful clinical tool for cancer diagnosis and predicting outcomes in patients with cancer. Finally, we suggest future directions for further elucidating the role of zinc deficiency in cancer development and progression.

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Section: Introductionmentioning

confidence: 93%

Zinc Deficiency as a General Feature of Cancer: a Review of the Literature

Sugimoto,

Lee,

Tanaka

et al. 2023

Biol Trace Elem Res

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“…Copper (Cu) is a trace element essential for the proper functioning of the body [122]. The recommended dietary intake of copper is 900 µg/day, while the best food sources are shellfish, whole grains, beans, nuts, potatoes, and organ meats (kidneys, liver) [123].…”

Section: Coppermentioning

confidence: 99%

“…Even a small increase in Cu concentration in the body can cause severe toxicity, oxidative stress, initiation, and promotion of carcinogenesis [124,125]. The 2022 case-control study by Barartabar et al showed that the Cu levels (p = 0.0001) in tumor tissue were significantly higher than in tumor margin tissue in 40 women with a histologically confirmed diagnosis of invasive ductal carcinoma [122]. Ceruloplasmin tests might be helpful in diagnosing Cu deficiencies.…”

Section: Coppermentioning

confidence: 99%

Micronutrient Status and Breast Cancer: A Narrative Review

Forma,

Grunwald,

Zembala

et al. 2024

IJMS

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Breast cancer is one of the most common cancers worldwide, at the same time being one of the most prevalent causes of women’s death. Many factors such as alcohol, weight fluctuations, or hormonal replacement therapy can potentially contribute to breast cancer development and progression. Another important factor in breast cancer onset includes micronutrient status. In this narrative review, we analyzed 23 micronutrients and their possible influence on breast cancer onset and progression. Further, the aim of this study was to investigate the impact of micronutrient status on the prevention of breast cancer and its possible influence on various therapeutic pathways. We researched meta-analyses, systemic and narrative reviews, retrospective studies, as well as original studies on human and animal models. The results of these studies indicate a possible correlation between the different levels of micronutrients and a decreased risk of breast cancer as well as a better survival rate. However, further studies are necessary to establish adequate doses of supplementation of the chosen micronutrients and the exact mechanisms of micronutrient impact on breast cancer therapy.

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“…Several studies show that breast cancer cells generate higher levels of ROS and decreased antioxidants compared to normal breast cells, suggesting that they are under increased oxidative stress. This increased ROS production has been linked to the activation of several oncogenes and the inactivation of tumor-suppressing genes, which are key factors in the development and progression of breast cancer [ 78 ]. For example, ROS aids in the survival of cancer cells by activating NF-kB, matrix metalloproteinases (MMPs), and VEGF-dependent angiogenesis and metastasis via MAPK/ERK1/2, p38, JNK, and PI3K/Akt pathways when exposed at a moderate concentration.…”

Section: Pathophysiology Of Breast Cancermentioning

confidence: 99%

The Role of Obesity in Breast Cancer Pathogenesis

Glassman

Asif

et al. 2023

Cells

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Research has shown that obesity increases the risk for type 2 diabetes mellitus (Type 2 DM) by promoting insulin resistance, increases serum estrogen levels by the upregulation of aromatase, and promotes the release of reactive oxygen species (ROS) by macrophages. Increased circulating glucose has been shown to activate mammalian target of rapamycin (mTOR), a significant signaling pathway in breast cancer pathogenesis. Estrogen plays an instrumental role in estrogen-receptor-positive breast cancers. The role of ROS in breast cancer warrants continued investigation, in relation to both pathogenesis and treatment of breast cancer. We aim to review the role of obesity in breast cancer pathogenesis and novel therapies mediating obesity-associated breast cancer development. We explore the association between body mass index (BMI) and breast cancer incidence and the mechanisms by which oxidative stress modulates breast cancer pathogenesis. We discuss the role of glutathione, a ubiquitous antioxidant, in breast cancer therapy. Lastly, we review breast cancer therapies targeting mTOR signaling, leptin signaling, blood sugar reduction, and novel immunotherapy targets.

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Assessment of Tissue Oxidative Stress, Antioxidant Parameters, and Zinc and Copper Levels in Patients with Breast Cancer

Cited by 5 publications

References 44 publications

Zinc Deficiency as a General Feature of Cancer: a Review of the Literature

Zinc Deficiency as a General Feature of Cancer: a Review of the Literature

Micronutrient Status and Breast Cancer: A Narrative Review

The Role of Obesity in Breast Cancer Pathogenesis

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